| Planta Med. 1982 May;45(5):28-30. |
| Vallesiachotamine and isovallesiachotamine from the seeds of Strychnos tricalysioides.[Pubmed: 17396774] |
METHODS AND RESULTS:
A new indole alkaloid, 11-hydroxypolyneuridine, was isolated from Vinca major subsp. major L. and the known indole alkaloids vallesiachotamine and Isovallesiachotamine from Vinca minor L. This is the first report on the alkaloids of both Vinca species growing in Turkey; vallesiachotamine and Isovallesiachotamine were isolated from a Vinca species for the first time. V. minor may be considered as a new source for these two alkaloids due to their occurrence in high amount in the aerial parts of the plant.
CONCLUSIONS:
The alkaloid extracts of the two Vinca species were found to have high lipid peroxidation inhibitory and DPPH radical scavenging activities. Anticholinesterase activity of the extracts was also very strong. |
| J Nat Prod. 2003 Jul;66(7):1017-21. |
| Turbinatine, a potential key intermediate in the biosynthesis of corynanthean-type indole alkaloids.[Pubmed: 12880329] |
METHODS AND RESULTS:
Extraction of the leaves of Chimarrhis turbinata has led to the isolation of turbinatine (1), a new corynanthean-type indole alkaloid, besides four known indole alkaloids, strictosidine, 5alpha-carboxystrictosidine, vallesiachotamine, and isovallesiachotamine. The structural determination of 1 was based on 1D and 2D spectroscopic data.
CONCLUSIONS:
An evaluation of the DNA-damaging activities of the isolates was performed by means of a bioassay using mutant strains of Saccharomyces cerevisiae, which indicated these compounds were weakly active. |
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