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产品编号 | CFN99189 |
| CAS编号 | 80321-63-7 | |
| 分子式 = 分子量 | C47H80O17 = 917.2 | |
| 产品纯度 | >=98% | |
| 物理属性 | White powder | |
| 化合物类型 | Triterpenoids | |
| 植物来源 | The herb of Gynostemma pentaphyllum (Thunb.) Makino | |
| ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 | ||
| 产品名称 | 产品编号 | CAS编号 | 包装 | QQ客服 |
| 七叶胆皂甙 | CFN99189 | 80321-63-7 | 1mg | QQ客服：2159513211 |
| 七叶胆皂甙 | CFN99189 | 80321-63-7 | 5mg | QQ客服：2159513211 |
| 七叶胆皂甙 | CFN99189 | 80321-63-7 | 10mg | QQ客服：2159513211 |
| 七叶胆皂甙 | CFN99189 | 80321-63-7 | 20mg | QQ客服：2159513211 |
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)| Description: | 1. Gypenosides (Gyp, Stevenleaf) induce apoptosis in human hepatoma cells through the up-regulation of Bax and Bak, and down-regulation of Bcl-2, release of mitochondrial cytochrome c and activation of caspase cascade. 2. Gypenosides induce ER stress and production of reactive oxygen species and Ca 2+ , change the ratio of Bcl-2 and Bax, followed by the dysfunction of mitochondria, cause cytochrome c release, activation of caspase-3 before leading to apoptosis, these results provide information towards an understanding of the mechanisms by which Gyp induces cell cycle arrest and apoptosis in human tongue cancer cells. 3. Gypenosides can inhibit invasion and migration of human tongue SCC4 cells by down-regulating proteins associated with these processes, resulting in reduced metastasis. 4. Gypenosides imply their remarkable preventative and therapeutic potential in treatment of neurological diseases involving glutamate and oxidative stress. 5. The extensive antioxidant effect of gypenosides may be valuable to the prevention and treatment of various diseases such as atherosclerosis, liver disease and inflammation. |
| Targets: | Bcl-2/Bax | Caspase | NF-kB | COX | ERK | MMP(e.g.TIMP) | NADPH-oxidase | Calcium Channel |
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.0903 mL | 5.4514 mL | 10.9027 mL | 21.8055 mL | 27.2569 mL |
| 5 mM | 0.2181 mL | 1.0903 mL | 2.1805 mL | 4.3611 mL | 5.4514 mL |
| 10 mM | 0.109 mL | 0.5451 mL | 1.0903 mL | 2.1805 mL | 2.7257 mL |
| 50 mM | 0.0218 mL | 0.109 mL | 0.2181 mL | 0.4361 mL | 0.5451 mL |
| 100 mM | 0.0109 mL | 0.0545 mL | 0.109 mL | 0.2181 mL | 0.2726 mL |
| 产品名称 | 产品编号 | CAS编号 | 分子式 = 分子量 | 位单 | 联系QQ |
| 1-甲基-6-氧代-1,6-二氢吡啶-3-羧酸; 1-Methyl-6-oxopyridine-3-carboxylic acid | CFN93233 | 3719-45-7 | C7H7NO3 = 153.13 | 20mg | QQ客服：1457312923 |
| 土荆皮甲酸-O-β-D-葡萄糖苷 ; Pseudolaric acid A-O-beta-D-glucopyranoside | CFN90725 | 98891-44-2 | C28H38O11 = 550.6 | 10mg | QQ客服：1457312923 |
| (4R)-阿马碱N-氧化物; 4,R-ajmalicine N-oxide | CFN98652 | 41590-29-8 | C21H24N2O4 = 368.4 | 5mg | QQ客服：1413575084 |
| Persicogenin; Persicogenin | CFN89467 | 28590-40-1 | C17H16O6 = 316.30 | 5mg | QQ客服：2159513211 |
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)
