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  • 中药标准品生产商,产品定制服务
  • 角鲨烯


    产品编号 CFN99208
    CAS编号 111-02-4
    分子式 = 分子量 C30H50 = 410.7
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Triterpenoids
    植物来源 The herbs of Catharanthus roseus
    产品名称 产品编号 CAS编号 包装 QQ客服
    角鲨烯 CFN99208 111-02-4 10mg QQ客服:2056216494
    角鲨烯 CFN99208 111-02-4 20mg QQ客服:2056216494
    角鲨烯 CFN99208 111-02-4 50mg QQ客服:2056216494
    角鲨烯 CFN99208 111-02-4 100mg QQ客服:2056216494
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    PMID: 29328914

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    doi: 10.1016/j.cmet.2020.01.002.

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
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  • 生物活性
    Description: Squalene, a naturally occurring substance found in plants, animals and humans, is a component of some adjuvants that is added to vaccines to enhance the immune response.Squalene shows several pharmacological properties such as hypolipidemic, hepatoprotective, cardioprotective, antioxidant, and antitoxicant activity. Squalene can significantly suppress colonic aberrant crypt foci (ACF) formation and crypt multiplicity strengthens the hypothesis that squalene possesses chemopreventive activity against colon carcinogenesis.
    Targets: COX | STAT | FOXP3 | Nrf2 | SOD | GPx
    In vivo:
    Mol Nutr Food Res. 2015 Feb;59(2):284-92.
    Dietary squalene supplementation improves DSS-induced acute colitis by downregulating p38 MAPK and NFkB signaling pathways.[Pubmed: 25387687]
    Squalene is a polyunsaturated triterpene, which has exhibited anticancer and antioxidant activities among others. We investigated dietary squalene supplementation effect on an acute colitis model induced by dextran sulfate sodium (DSS) in C57BL/6 mice.
    Mice were fed from weaning with squalene at 0.02% and 0.1%. After 4 weeks, mice were exposed to 3% DSS for 5 days developing acute colitis. After DSS removal (5 days), colons were histological and biochemically processed. Our results showed that dietary squalene treatment exerts anti-inflammatory action in DSS-induced acute colitis. Western blot revealed that squalene downregulated COX-2 (where COX is cyclooxygenase) and inducible nitric oxide synthase system by inhibition of mitogen-activated protein kinase p38 and the nuclear factor-kappa B signaling pathways, preventing an increase in the cytokines levels. Under our experimental conditions, STAT3 and FOXP3 (where FOXP3 is forkhead box P3) were not modified and the transcriptional regulation of antioxidant and/or detoxifying enzymes, Nrf2 (where Nrf2 is nuclear factor (erythroid-derived 2)-like 2), was reduced in DSS-induced colitis. However, any change could be observed after squalene supplementation.
    Squalene was able to improve the oxidative events and returned proinflammatory proteins expression to basal levels probably through p38 mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways. However, supplementary studies are needed in order to provide a basis for developing a new dietary supplementation strategy.
    Clin Chim Acta. 2006 Feb;364(1-2):335-42.
    Effect of squalene on cyclophosphamide-induced toxicity.[Pubmed: 16150433]
    Toxicity due to drugs used for neoplastic disorders is extensively documented. Cyclophosphamide (CYP) is a widely used antineoplastic drug, which could cause toxicity of normal cells due to its toxic metabolites. We evaluated the protective role of squalene (SQ) in the toxicity induced by cyclophosphamide.
    The activities of serum marker enzymes, clinical chemistry parameters and histopathology studies were done according to the standard procedures in the control and experimental groups of rats. Toxicity of the organs like heart, kidney and liver was evidenced from significant (P<0.05) increases of CK, LDH, AST, ALT, ALP, urea, creatinine and total bilirubin in cyclophosphamide- (150 mg/kg for 2 days) administered rats. Abnormal activities of these enzymes in the organs and serum total protein and cholesterol were also observed. No significant changes were observed in triglycerides in serum. Squalene oral treatment exerted protection towards these organs at a dose of 0.4 ml/day/rat. Histopathological examinations also confirmed the protective efficacy of squalene.
    Squalene may be efficacious as a cytoprotectant in cyclophosphamide-induced toxicities.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4349 mL 12.1743 mL 24.3487 mL 48.6973 mL 60.8717 mL
    5 mM 0.487 mL 2.4349 mL 4.8697 mL 9.7395 mL 12.1743 mL
    10 mM 0.2435 mL 1.2174 mL 2.4349 mL 4.8697 mL 6.0872 mL
    50 mM 0.0487 mL 0.2435 mL 0.487 mL 0.9739 mL 1.2174 mL
    100 mM 0.0243 mL 0.1217 mL 0.2435 mL 0.487 mL 0.6087 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    反式-橙花叔醇; Nerolidol CFN98638 7212-44-4 C15H26O = 222.4 20mg QQ客服:1457312923
    9-氧代橙花叔醇; 9-Oxonerolidol CFN98997 58865-88-6 C15H24O2 = 236.4 5mg QQ客服:3257982914
    (Z)-3,11-dimethy-7-methylene-9,14-epoxy-1,6,10-dodecatrien-3-ol; (Z)-3,11-dimethy-7-methylene-9,14-epoxy-1,6,10-dodecatrien-3-ol CFN95402 1392202-57-1 C15H24O2 = 236.4 10mg QQ客服:2056216494
    四羟基鲨稀; Tetrahydroxysqualene CFN99062 1043629-23-7 C30H50O4 = 474.7 5mg QQ客服:2159513211
    角鲨烯; Squalene CFN99208 111-02-4 C30H50 = 410.7 20mg QQ客服:1413575084
    三十碳六烯-2,3-二醇; Squalene-2,3-diol CFN99456 14031-37-9 C30H52O2 = 444.7 5mg QQ客服:215959384
    番荔枝素; Annonacin CFN97856 111035-65-5 C35H64O7 = 596.89 5mg QQ客服:1413575084





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