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  • 剑麻皂苷元； 剑麻皂甙元； 剑麻皂素

    • 剑麻皂苷元； 剑麻皂甙元； 剑麻皂素

    Tigogenin

    剑麻皂苷元； 剑麻皂甙元； 剑麻皂素
    		产品编号 CFN98501
    CAS编号 77-60-1
    分子式 = 分子量 C27H44O3 = 416.64
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The herbs of Agave sisalana Perrine
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    剑麻皂苷元； 剑麻皂甙元； 剑麻皂素 CFN98501 77-60-1 10mg QQ客服：1457312923
    剑麻皂苷元； 剑麻皂甙元； 剑麻皂素 CFN98501 77-60-1 20mg QQ客服：1457312923
    剑麻皂苷元； 剑麻皂甙元； 剑麻皂素 CFN98501 77-60-1 50mg QQ客服：1457312923
    剑麻皂苷元； 剑麻皂甙元； 剑麻皂素 CFN98501 77-60-1 100mg QQ客服：1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • University of Minnesota (USA)
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  • University of Auckland (New Zealand)
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  • Weizmann Institute of Science (Israel)
  • Universidade Federal de Goias (UFG) (Brazil)
  • Uniwersytet Gdański (Poland)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • University of Maryland School of Medicine (USA)
  • More...
    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Exp Neurobiol.2018, 27(3):200-209
  • Food Res Int.2017, 96:40-45
  • Biomedicines.2024, 12(3):495.
  • Inflammation.2021, doi: 10.1007
  • Invest New Drugs.2017, 35(2):166-179
  • Mol Cells.2018, 41(8):771-780
  • Phytochem Anal.2021, 32(6):970-981.
  • Pak J Pharm Sci.2018, 31:311-315
  • Dis Markers.2022, 2022:2380879.
  • Anat Rec2018, 24264
  • Malaysian J of Fundamental and Applied Sciences 2018, 14(3):368-373
  • Phytomedicine.2023, 116:154841.
  • Int J Mol Sci.2022, 23(15):8687.
  • Front Plant Sci.2018, 9:1424
  • Pharmacognosy Journal.2022, 14,4,327-337.
  • Eur J Pharmacol.2020, 889:173589.
  • Chin J Pharm Anal.2019, 39(7):1217-1228
  • Foods.2022, 11(12):1773.
  • Saudi Pharm J2020, 10.1016
  • Korean Journal of Pharmacognosy.2020, 51(2):100-106
  • Natural Product Communications2020, doi: 10.1177.
  • Advances in Traditional Medicine2020, 10.1007
  • FUTURE VIROLOGYVOL.2023, 18(5).
  • ...
    • 生物活性
    Description: Tigogenin is one of steroidal sapogenins which is widely used for synthesizing steroid drugs. It might have protective effect on bone and be helpful in preventing the development of osteoporosis.Tigogenin induces apoptosis, associated with overexpression of COX-2 correlated with overproduction of endogenous PGE2. Tigogenin inhibited of PPARgamma and via p38 MAPK pathway.
    Targets: COX | PGE | PPAR | p38MAPK
    In vitro:
    Int J Mol Med. 2007 Oct;20(4):451-60.
    Inhibition of human rheumatoid arthritis synovial cell survival by hecogenin and tigogenin is associated with increased apoptosis, p38 mitogen-activated protein kinase activity and upregulation of cyclooxygenase-2.[Pubmed: 17786275]
    We conducted our study to assess the antiproliferative and proapoptotic potential of hecogenin and tigogenin, two saponins which are structurally similar to diosgenin.
    METHODS AND RESULTS:
    We particularly focused our attention on mitogen-activated protein kinase (MAPK) activation in relation to apoptosis but also with the COX-2 expression and activity. Rheumatoid arthritis (RA) synoviocytes were isolated from fresh synovial biopsies obtained from five RA patients undergoing hip arthroplasty. Measurement of cell proliferation was determined using the MTT assay. Apoptosis was evaluated by studying caspase-8, caspase-9 and caspase-3 activities but also by quantification of DNA fragmentation. Quantification of human phospho-MAPKs was realized by ELISA. COX-2 expression was demonstrated by Western blot analysis and COX-2 activity by assay of endogenous prostaglandin E2 (PGE2) production. Tigogenin was more effective than hecogenin in inducing apoptosis in human RA fibroblast-like synoviocytes (FLS) which was caspase dependent but poly(ADP-ribose) polymerase independent and characterized by DNA fragmentation. Our results demonstrated hecogenin- and tigogenin-induced apoptosis through activation of p38 without affecting the JNK and ERK pathways. Indeed, pretreatment with a p38 inhibitor decreased saponin-induced apoptosis with a significant decrease in DNA fragmentation. Furthermore, the rate of apoptosis induced by hecogenin or tigogenin was associated with overexpression of COX-2 correlated with overproduction of endogenous PGE2.
    CONCLUSIONS:
    These new results provide strong evidence that a family of structurally similar plant steroids is capable of inducing apoptosis in human RA FLS with different rates and different signalling pathways. This study also confirms the discussed appearance of the downregulation or upregulation of COX-2 in cell apoptosis as a function of cell type.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4002 mL 12.0008 mL 24.0015 mL 48.0031 mL 60.0038 mL
    5 mM 0.48 mL 2.4002 mL 4.8003 mL 9.6006 mL 12.0008 mL
    10 mM 0.24 mL 1.2001 mL 2.4002 mL 4.8003 mL 6.0004 mL
    50 mM 0.048 mL 0.24 mL 0.48 mL 0.9601 mL 1.2001 mL
    100 mM 0.024 mL 0.12 mL 0.24 mL 0.48 mL 0.6 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    菝葜皂苷元; 菝葜皂甙元; Sarsasapogenin CFN99779 126-19-2 C27H44O3 = 416.64 20mg QQ客服：1413575084
    剑麻皂苷元； 剑麻皂甙元； 剑麻皂素; Tigogenin CFN98501 77-60-1 C27H44O3 = 416.64 20mg QQ客服：2159513211
    剑麻皂苷元乙酸酯; Tigogenin acetate CFN91164 2530-07-6 C29H46O4 = 458.7 10mg QQ客服：2159513211
    薯蓣皂苷元; Diosgenin CFN99515 512-04-9 C27H42O3 = 414.63 20mg QQ客服：1457312923
    偏诺皂苷元; Pennogenin CFN90706 507-89-1 C27H42O4 = 430.62 5mg QQ客服：2159513211
    海柯吉宁; Hecogenin CFN98586 467-55-0 C27H42O4 = 430.62 20mg QQ客服：2159513211
    蒺藜苷元; (25R)-Spirost-4-ene-3,12-dione CFN91702 6875-60-1 C27H38O4 = 426.6 5mg QQ客服：1457312923
    吉托皂苷元; Gitogenin CFN93779 511-96-6 C27H44O4 = 432.6 5mg QQ客服：2159513211
    绿莲皂甙元; Chlorogenin CFN91558 562-34-5 C27H44O4 = 432.6 5mg QQ客服：1457312923

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