天冬宁B

Shatavarin IV

	产品编号	CFN70458
	CAS编号	84633-34-1
	分子式 = 分子量	C₄₅H₇₄O₁₇ = 887.1
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Steroids
	植物来源	The roots of Asparagus racemosus
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产品名称	产品编号	CAS编号	包装	QQ客服
天冬宁B	CFN70458	84633-34-1	1mg	QQ客服：1413575084
天冬宁B	CFN70458	84633-34-1	5mg	QQ客服：1413575084
天冬宁B	CFN70458	84633-34-1	10mg	QQ客服：1413575084
天冬宁B	CFN70458	84633-34-1	20mg	QQ客服：1413575084

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Description:

Shatavarin IV shows in vitro anti-malassezia activity. Shatavarins (containing shatavarin IV) rich fraction (AR-2B) exhibits significant anticancer activity in both in vitro and in vivo experimental models.

In vitro:

International journal of cosmetic ence, 2013, 36(1):74-78.

In vitro Anti-Malassezia Activity and Potential Use in Anti-dandruff Formulation of Asparagus racemosus.[Reference: WebLink]

Malassezia species are frequently associated with dandruff and seborrhoeic dermatitis. The study was conducted to evaluate anti-fungal activities of the extracts obtained from the roots of Asparagus racemosus Willd against Malassezia furfur and M. globosa.
METHODS AND RESULTS:
Asparagus racemosus roots were successively extracted with the series of solvents, that is, hexane, ethanol and water, and also a saponin-enriched fraction was prepared. The amounts of saponin (equivalent to shatavarin IV) in the extracts were determined using ELISA. The extracts were tested for anti-fungal activity by disc diffusion and broth microdilution methods. By disc diffusion, only the ethanolic and saponin-enriched extracts demonstrated anti-fungal activity against M. furfur and M. globosa at the concentration of 1 mg per disc whereas the extracts with other solvents were ineffective. Multiple concentrations using the broth microdilution method against M. furfur and M. globosa yielded minimum inhibitory concentrations (MICs) of 25 mg mL(-1) for the ethanolic extract but much higher potency for the saponin-enriched extract: MICs to 0.20 and 0.40 mg mL(-1) for M. furfur and M. globosa, respectively. These extracts showed no antagonist effect with the anti-fungal agents, ketoconazole and zinc pyrithione.
CONCLUSIONS:
These studies revealed the antifungal activity of A. racemosus roots extracts. Because A. racemosus is also anti-inflammatory agent, it has the potential use as an active ingredient in an anti-dandruff formulation.

In vivo:

Indian Journal of Pharmacology, 2012, 44(6):732.

Shatavarins (containing Shatavarin IV) with anticancer activity from the roots of Asparagus racemosus.[Reference: WebLink]

The anticancer activity of shatavarins (containing shatavarin IV) isolated from the roots of Asparagus racemosus (Wild) was evaluated using in vitro and in vivo experimental models.
METHODS AND RESULTS:
The shatavarin IV was isolated from ethyl acetate insoluble fraction (AR-2B) of chloroform:methanol (2:1) (AR-2) extract of A. racemosus roots. The cytotoxicity (in vitro) of shatavarin IV and other shatavarins rich fraction was carried out using of MTT assay using MCF-7 (human breast cancer), HT-29 (human colon adenocarcinoma), and A-498 (human kidney carcinoma) cell lines. The in vivo anticancer activity of shatavarins (containing shatavarin IV) was evaluated against Ehrlich ascites carcinoma (EAC) tumor bearing mice. The isolated shatavarin IV (84.69 %) along with shatavarins rich fraction, coded AR-2B containing 5.05% shatavarin IV showed potent cytotoxicity. Oral administration of AR-2B to tumor bearing mice at doses of 250 and 500 mg/kg body weight for 10 days, showed significant reduction in percent increase in body weight, tumor volume, packed cell volume, viable tumor cell count, and increased non-viable cell count when compared to the untreated mice of the EAC control group. The restoration of hematological parameters towards normalcy was also observed.
CONCLUSIONS:
The result suggests that the shatavarins (containing shatavarin IV) rich fraction (AR-2B) exhibits significant anticancer activity in both in vitro and in vivo experimental models.

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.1273 mL	5.6363 mL	11.2727 mL	22.5454 mL	28.1817 mL
5 mM	0.2255 mL	1.1273 mL	2.2545 mL	4.5091 mL	5.6363 mL
10 mM	0.1127 mL	0.5636 mL	1.1273 mL	2.2545 mL	2.8182 mL
50 mM	0.0225 mL	0.1127 mL	0.2255 mL	0.4509 mL	0.5636 mL
100 mM	0.0113 mL	0.0564 mL	0.1127 mL	0.2255 mL	0.2818 mL

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天冬宁B

Shatavarin IV

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