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  • 洋川芎内酯I

    Senkyunolide I

    产品编号 CFN99596
    CAS编号 94596-28-8
    分子式 = 分子量 C12H16O4 = 224.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Miscellaneous
    植物来源 The roots of Ligusticum chuanxiong hort
    产品名称 产品编号 CAS编号 包装 QQ客服
    洋川芎内酯I CFN99596 94596-28-8 10mg QQ客服:1413575084
    洋川芎内酯I CFN99596 94596-28-8 20mg QQ客服:1413575084
    洋川芎内酯I CFN99596 94596-28-8 50mg QQ客服:1413575084
    洋川芎内酯I CFN99596 94596-28-8 100mg QQ客服:1413575084
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
  • Ain Shams University (Egypt)
  • Universit?t Basel (Switzerland)
  • Universidad Industrial de Santander (Colombia)
  • Florida A&M University (USA)
  • Heidelberg University (Germany)
  • Tokyo Woman's Christian University (Japan)
  • Worcester Polytechnic Institute (USA)
  • Indian Institute of Science (India)
  • University of Melbourne (Australia)
  • National Research Council of Canada (Canada)
  • Celltrion Chemical Research Institute (Korea)
  • Mahatma Gandhi University (India)
  • University Medical Center Mainz (Germany)
  • University of Cincinnati (USA)
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  • ...
  • 生物活性
    Description: Senkyunolide I may be an active component of L. chuanxiong, traditionally used to treat migraine, it can protect rat brain against focal cerebral ischemia-reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3, the neuroprotective mechanisms of itI are associated with its anti-oxidation and anti-apoptosis properties. Senkyunolide I can reduce the metamorphose damage of the RBC caused by ConA, the aggregation of the RBC can be alleviated by it.
    Targets: ERK | Nrf2 | HO-1 | Bcl-2/Bax | Caspase | 5-HT Receptor | NO
    In vitro:
    Lishizhen Medicine & Materia Medica Research, 2003, 14(12):738-9.
    Effects of Ferulic Acid,Senkyunolide H and Senkyunolide I on Erythrocytes[Reference: WebLink]
    To study the effects of Ferulic acid、Senkyunolide H and Senkyunolide I on erythrocytes deformability and aggregation.
    Deformability and aggregation of the dog RBC were evaluated through erythrocytes deformability experiment. Ferulic acid、Senkyunolide H and Senkyunolide I can reduce the metamorphose damage of the RBC caused by ConA.
    The aggregation experiment also has indicated that aggregation of the RBC can be alleviated by them.
    In vivo:
    Brain Res. 2015 Apr 24;1605:39-48.
    Senkyunolide I protects rat brain against focal cerebral ischemia-reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3.[Pubmed: 25698615]
    Oxidative damage and apoptosis are critical factors contributing to neuronal death during a stroke. The aim of the present study was to evaluate the neuroprotective effects of Senkyunolide I (SEI) on focal cerebral ischemia-reperfusion (I/R) injury in rats, and investigate the underlying mechanisms.
    Male Sprague-Dawley rats were subjected to transient middle cerebral artery occlusion (tMCAO) for 2h, followed by 24h reperfusion, and then randomly assigned into four groups: Sham (sham-operated), Vehicle (tMCAO +normal saline), Senkyunolide I-L (tMCAO +SEI 36 mg/kg) and Senkyunolide I-H (tMCAO +SEI 72 mg/kg) groups. Senkyunolide I was administered intravenously, 15 min after occlusion. Neurological deficit, brain edema and infarct volume were detected after 24h of reperfusion. Histological structures of cortices and hippocampus were observed by hematoxylin and eosin staining. Biochemical indexes in the cortex were assayed by colorimetry. The impact of Senkyunolide I on the Nrf2-ARE-interaction was assayed using a luciferase reporter gene. Western blotting was performed to analysis the expressions of proteins related to anti-oxidation and apoptosis. Senkyunolide I administration significantly ameliorated the neurological deficit, reduced the infarct volume and brain edema, reversed the cerebral morphologic damage, decreased the levels of MDA and increased the activities of superoxide dismutase. Furthermore, the high dose Senkyunolide I could significantly activate the Nrf2/ARE pathway by up-regulating the phosphorylation of Erk1/2 and inducing Nrf2 nuclear translocation with enhanced HO-1 and NQO1 expressions. Additionally, treatment with Senkyunolide I remarkably promoted the ratio of Bcl-2/Bax and inhibited the expressions of cleaved caspase 3 and caspase 9.
    These results suggest that the neuroprotective mechanisms of Senkyunolide I are associated with its anti-oxidation and anti-apoptosis properties.
    J Pharm Biomed Anal. 2013 Jul-Aug;81-82:178-86.
    Identification of senkyunolide I metabolites in rats using ultra performance liquid chromatography/quadrupole-time-of-flight tandem mass spectrometry.[Pubmed: 23666254]
    Ligusticum chuanxiong Hort. (Umbelliferae) has been widely prescribed to treat cardiovascular disease in China for centuries. Senkyunolide I is one of the major bioactive components in L. chuanxiong, which shows pharmacological activities against migraines and oxidative damage.
    In this paper, ultra performance liquid chromatography/quadrupole-time-of-flight tandem mass spectrometry (UPLC/Q-TOF-MS) was applied for the rapid analysis of senkyunolide I metabolites in rats after its intravenous administration. The non-metabolized parent compound and eighteen metabolites from drug-treated samples in rat plasma, urine and bile were identified. Our analysis indicated that methylation, hydration, epoxidation, glucuronidation and glutathione conjugation were the major pathways of senkyunolide I metabolism in vivo.
    This study provides important information regarding the metabolism of senkyunolide I, which will be helpful for understanding its mechanism of action. Furthermore, this work demonstrates the potential of using UPLC/Q-TOF-MS for the rapid and reliable characterization of the metabolites of natural products.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.4583 mL 22.2916 mL 44.5831 mL 89.1663 mL 111.4579 mL
    5 mM 0.8917 mL 4.4583 mL 8.9166 mL 17.8333 mL 22.2916 mL
    10 mM 0.4458 mL 2.2292 mL 4.4583 mL 8.9166 mL 11.1458 mL
    50 mM 0.0892 mL 0.4458 mL 0.8917 mL 1.7833 mL 2.2292 mL
    100 mM 0.0446 mL 0.2229 mL 0.4458 mL 0.8917 mL 1.1146 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3-正丁烯基苯酞; 3-亚丁基-1(3H)-异苯并呋喃酮; 3-Butylidenephthalide CFN99588 551-08-6 C12H12O2 = 188.22 20mg QQ客服:1413575084
    新蛇床内酯; Neocnidilide CFN80081 4567-33-3 C12H18O2 = 194.27 20mg QQ客服:215959384
    洋川芎内酯A; Senkyunolide A CFN99594 62006-39-7 C12H16O2 = 192.25 20mg QQ客服:2159513211
    洋川芎内酯G; Senkyunolide G CFN93303 94530-85-5 C12H16O3 = 208.25 5mg QQ客服:2056216494
    蒿本内酯; Ligustilide CFN99932 4431-01-0 C12H14O2 = 190.24 20mg QQ客服:1413575084
    洋川芎内酯N; Senkyunolide N CFN95449 140694-58-2 C12H18O4 = 226.3 10mg QQ客服:3257982914
    洋川芎内酯H; Senkyunolide H CFN99595 94596-27-7 C12H16O4 = 224.3 20mg QQ客服:3257982914
    洋川芎内酯I; Senkyunolide I CFN99596 94596-28-8 C12H16O4 = 224.3 20mg QQ客服:3257982914
    6-Hydroxy-7-methoxydihydroligustilide; 6-Hydroxy-7-methoxydihydroligustilide CFN95289 210036-09-2 C13H18O4 = 238.3 5mg QQ客服:1457312923
    Riligustilide; Riligustilide CFN95457 89354-45-0 C24H28O4 = 380.5 5mg QQ客服:2056216494





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