克氏千里光碱
Senkirkine
|
|
产品编号 |
CFN00424 |
| CAS编号 |
2318-18-5 |
| 分子式 = 分子量 |
C19H27NO6 = 365.42 |
| 产品纯度 |
>=98% |
| 物理属性 |
Powder |
| 化合物类型 |
Alkaloids |
| 植物来源 |
The herbs of Farfugium japonicum |
| ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 克氏千里光碱 |
CFN00424 |
2318-18-5 |
1mg |
QQ客服：2159513211 |
| 克氏千里光碱 |
CFN00424 |
2318-18-5 |
5mg |
QQ客服：2159513211 |
| 克氏千里光碱 |
CFN00424 |
2318-18-5 |
10mg |
QQ客服：2159513211 |
| 克氏千里光碱 |
CFN00424 |
2318-18-5 |
20mg |
QQ客服：2159513211 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
Weizmann Institute of Science (Israel)
The Ohio State University (USA)
Heidelberg University (Germany)
Sanford Burnham Prebys Medical Discovery Institute (USA)
VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
Institute of Chinese Materia Medica (China)
Monash University (Australia)
University of Fribourg (Switzerland)
Kamphaengphet Rajabhat University (Thailand)
Johannes Gutenberg University Mainz (JGU) (Germany)
Northeast Normal University Changchun (China)
Medizinische Universit?t Wien (Austria)
Florida A&M University (USA)
The Vancouver Prostate Centre (VPC) (Canada)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
Food Sci Nutr.2023, 00:1-10.
Int J Food Sci Nutr.2019, 70(7):825-833
Phytother Res.2019, 33(3):676-689
Pharmacol Rep.2019, 71(2):289-298
Separations2023, 10(2), 131.
Rev. Chim.2020, 71(3),558-564
J Appl Biol Chem2022, 65:343−348.
J AOAC Int.2023, 106(1):56-64.
| Description: |
Brood pattern analysis with Senkirkine shows maximum sensitivity in the late spermatid stage of spermatogenesis.
|
| In vitro: |
| Mol Nutr Food Res. 2014 May;58(5):995-1004. | | Structure-activity relationship in the passage of different pyrrolizidine alkaloids through the gastrointestinal barrier: ABCB1 excretes heliotrine and echimidine.[Pubmed: 24375927] |
1,2-Unsaturated pyrrolizidine alkaloids (PA) are found in plants such as Asteraceae and Boraginaceae families. Acute PA poisoning via contaminated food or feed causes severe damage to liver depending on species-specific oral bioavailability. For assessing PA bioavailability, their passage across the intestinal barrier was investigated using Caco-2 cells.
METHODS AND RESULTS:
Differentiated Caco-2 cells were exposed in transport chambers to the PA heliotrine (Hn), echimidine (Em), senecionine (Sc), and Senkirkine (Sk). Cell supernatants were analyzed by LC-MS/MS. PA pass Caco-2 monolayer from the apical into basolateral compartment depending on their chemical structure. Compared to the cyclic diesters Sc and Senkirkine with a passage rate of 47% ± 4 and 40% ± 3, respectively, the transferred amount of the monoester Hn (32% ± 3) and open-chained diester Em (13% ± 2) was substantially lower. This suggested an active transport of Hn and Em. Using Madin-Darby canine kidney II/P-glycoprotein (ABCB1)-overexpressing cells, the active excretion of Hn and Em by ABCB1 from the gastrointestinal epithelium into the gut lumen was shown.
CONCLUSIONS:
PA cross the intestinal barrier structure-dependently. The passage of the noncyclic PA Hn and Em is reduced by an ABCB1-driven efflux into the gastrointestinal lumen resulting in a decreased oral bioavailability. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
2.7366 mL |
13.6829 mL |
27.3658 mL |
54.7315 mL |
68.4144 mL |
| 5 mM |
0.5473 mL |
2.7366 mL |
5.4732 mL |
10.9463 mL |
13.6829 mL |
| 10 mM |
0.2737 mL |
1.3683 mL |
2.7366 mL |
5.4732 mL |
6.8414 mL |
| 50 mM |
0.0547 mL |
0.2737 mL |
0.5473 mL |
1.0946 mL |
1.3683 mL |
| 100 mM |
0.0274 mL |
0.1368 mL |
0.2737 mL |
0.5473 mL |
0.6841 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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