半枝莲碱 X

Scutebarbatine X

	产品编号	CFN96691
	CAS编号	1312716-26-9
	分子式 = 分子量	C₃₄H₃₈N₂O₁₀ = 634.68
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Diterpenoids
	植物来源	The whole plants of Scutellaria barbata.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
半枝莲碱 X	CFN96691	1312716-26-9	1mg	QQ客服：2159513211
半枝莲碱 X	CFN96691	1312716-26-9	5mg	QQ客服：2159513211
半枝莲碱 X	CFN96691	1312716-26-9	10mg	QQ客服：2159513211
半枝莲碱 X	CFN96691	1312716-26-9	20mg	QQ客服：2159513211

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Regional Crop Research Institute (Korea)

University of Auckland (New Zealand)

Shanghai University of TCM (China)

Utrecht University (Netherlands)

University of Wisconsin-Madison (USA)

Lund University (Sweden)

The University of Newcastle (Australia)

CSIRO - Agriculture Flagship (Australia)

Sapienza University of Rome (Italy)

Donald Danforth Plant Science Center (USA)

Helmholtz Zentrum München (Germany)

Chinese University of Hong Kong (China)

University of Limpopo (South Africa)

Kamphaengphet Rajabhat University (Thailand)

More...

Description:

Scutebarbatine X can inhibit nitric oxide production efficiently with IC50 values of lower than 50 uM, it may have potential effects on the reduction of neuroinflammation.

Targets:

In vitro:

Chem Biodivers. 2017 Aug 14.

Constituents from Scutellaria barbata Inhibiting Nitric Oxide Production in LPS-stimulated Microglial Cells.[Pubmed: 28805952]

METHODS AND RESULTS:
The arial parts of Scutellaria barbata D. Don (Lamiaceae) efficiently inhibited NO production in BV2 microglial cells, and the active constituents were further isolated based on activity-guided isolation using silica-gel column chromatography, RP-C18 MPLC and prep-HPLC. As the results, 2 flavonoids including 6-methoxynaringenin (1) and 6-O-methylscutellarein (5), and 6 neo-clerodane diterpenes such as scutebarbatine W (2), scutebatas B (3), scutebarbatine B (4), scutebarbatine A (6), 6-O-nicotinolylscutebarbatine G (7) and Scutebarbatine X (8) were isolated. The structures of these compounds were elucidated based on NMR and MS data, and the comparison of literature values.
CONCLUSIONS:
All the compounds except compound 7 inhibited NO production efficiently with IC50 values of lower than 50 μM. Particularly, compound 1 and 8 were the most efficient with IC50 values of 25.8 and 27.4 μM, respectively. This is the first report suggesting the potential of S. barbata on the reduction of neuroinflammation.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
6-O-烟酰半枝莲素C; 6-O-Nicotinoylbarbatin C	CFN99028	1015776-92-7	C₂₆H₃₁NO₆ = 453.5	5mg	QQ客服：3257982914
半枝莲碱B; Scutebarbatine B	CFN97471	905929-95-5	C₃₃H₃₅NO₇ = 557.6	5mg	QQ客服：1457312923
半枝莲碱A; Scutebarbatine A	CFN99832	176520-13-1	C₃₂H₃₄N₂O₇ = 558.6	5mg	QQ客服：215959384
Scutebata C; Scutebata C	CFN99324	1207181-59-6	C₂₈H₃₅NO₉ = 529.6	5mg	QQ客服：1457312923
Scutebata B; Scutebata B	CFN99323	1207181-58-5	C₃₅H₃₉NO₁₀ = 633.7	5mg	QQ客服：1413575084
Scutebata A; Scutebata A	CFN99322	1207181-57-4	C₃₆H₄₀O₁₀ = 632.7	5mg	QQ客服：2159513211
半枝莲碱 X; Scutebarbatine X	CFN96691	1312716-26-9	C₃₄H₃₈N₂O₁₀ = 634.68	5mg	QQ客服：2056216494
16-Hydroxy-2-oxocleroda-3,13-dien-15,16-olide; 16-Hydroxy-2-oxocleroda-3,13-dien-15,16-olide	CFN97965	165459-53-0	C₂₀H₂₈O₄ = 332.4	5mg	QQ客服：2159513211
(4->2)-Abeo-16-hydroxycleroda-2,13-dien-15,16-olide-3-al; (4->2)-Abeo-16-hydroxycleroda-2,13-dien-15,16-olide-3-al	CFN89211	935293-70-2	C₂₀H₂₈O₄ = 332.44	5mg	QQ客服：3257982914
6alpha,16,18-三羟基克罗-3,13-二烯-15,16-内酯; 6alpha,16,18-Trihydroxycleroda-3,13-dien-15,16-olide	CFN97990	1017233-48-5	C₂₀H₃₀O₅ = 350.5	5mg	QQ客服：1457312923

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.5756 mL	7.878 mL	15.756 mL	31.5119 mL	39.3899 mL
5 mM	0.3151 mL	1.5756 mL	3.1512 mL	6.3024 mL	7.878 mL
10 mM	0.1576 mL	0.7878 mL	1.5756 mL	3.1512 mL	3.939 mL
50 mM	0.0315 mL	0.1576 mL	0.3151 mL	0.6302 mL	0.7878 mL
100 mM	0.0158 mL	0.0788 mL	0.1576 mL	0.3151 mL	0.3939 mL