| In vitro: |
| Journal of Tropical & Subtropical Botany, 2015 , 23 (3) :329-33. | | Studies on Chemical Compositions and Cytotoxicities from Roots of Aphanamixis grandifolia Bl[Reference: WebLink] |
METHODS AND RESULTS:
In order to understand the antitumor active ingredients of Aphanamixis grandifolia Bl., nine compounds were isolated from 95% ethanol extract of its roots. They were identifi ed as 7-hydroxycadalene(1), dregeana-1(2), 4-oxopinoresinol(3), 4-ketopinoresinol(4), 6-deoxyjacareubin(5), Schleicheol 1(6), stigmasterol(7), β-sitosterol(8), and daucosterol(9) on the basis of spectral data. Compounds 1– 6 were isolated from the genus Aphanamixis for the fi rst time, and the 13 C NMR spectral data of compound 1 was reported for the fi rst time.
CONCLUSIONS:
Compounds 1 and 5 showed inhibition of the proliferation of K562 cell line, and compounds 1, 5 and 6 possessed inhibitory activity against SGC-7901 cell line. |
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