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  • 肌氨酸

    Sarcosine

    肌氨酸
    产品编号 CFN90603
    CAS编号 107-97-1
    分子式 = 分子量 C3H7NO2 = 89.09
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The barks of Quillaia saponaria.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    肌氨酸 CFN90603 107-97-1 10mg QQ客服:2056216494
    肌氨酸 CFN90603 107-97-1 20mg QQ客服:2056216494
    肌氨酸 CFN90603 107-97-1 50mg QQ客服:2056216494
    肌氨酸 CFN90603 107-97-1 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Queensland (Australia)
  • Univerzita Karlova v Praze (Czech Republic)
  • Kyoto University (Japan)
  • Universidade do Porto (Portugal)
  • Universidade da Beira Interior (Germany)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • Universite Libre de Bruxelles (Belgium)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Antioxidants (Basel).2020, 9(6):544.
  • Food Chem.2016, 191:81-90
  • J Phys Chem Lett.2021, 12(7):1793-1802.
  • Dis Markers.2022, 2022:2380879.
  • Appl. Sci. 2021, 11(17),7829
  • Molecules.2018, 23(9):E2121
  • Appl. Sci. 2021, 11(22),10569
  • Food Chem.2023, 424:136383.
  • Biomed Pharmacother.2021, 139:111585.
  • Cell Death Differ.2021, 1-8.
  • Patanjali Research Foundation2024, ssrn.4807357
  • Food Chem Toxicol.2024, 186:114589.
  • Molecules.2019, 24(16):E2985
  • Heliyon.2022, e12337.
  • Molecules.2019, 25(1):E103
  • Internoational J of Toxicology2020, 10.1177.
  • Biochem Biophys Res Commun.2019, 518(4):732-738
  • Cells.2021, 10(10):2633.
  • J AOAC Int.2021, 104(6):1634-1651.
  • Food Chem.2017, 221:1135-1144
  • Pharmaceuticals (Basel).2021, 14(8):742.
  • J Mater Chem B.2019, 7(39):5896-5919
  • J Biochem Mol Toxicol.2022, e23211.
  • ...
  • 生物活性
    Description: Sarcosine is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist, it preconditioning induces ischemic tolerance against global cerebral ischemia and this neuroprotective state is associated with changes in glycine transport and reduction of NR2B-containing NMDAR expression.Sarcosine modulates endothelial cell function relevant to angiogenesis through modulation of PI3K/Akt/mTOR pathway.
    Targets: PI3K | mTOR | Akt | NMDAR | GlyT
    In vitro:
    J Cancer Res Ther. 2014 Jul-Sep;10(3):603-10.
    Effect of sarcosine on endothelial function relevant to angiogenesis.[Pubmed: 25313747]
    Endothelial cells (ECs) respond to changes in metabolic status and switch over to angiogenic phenotype. There are several metabolites known to mediate this transition; however, the effect of sarcosine that accumulates in invasive prostate cancer is not known. The objective of the study was to examine whether sarcosine influences EC function and affects angiogenesis.
    METHODS AND RESULTS:
    The effect of sarcosine was studied using different model systems including chick chorioallantoic membrane (CAM), rat aortic rings in culture, and human umbilical vein ECs (HUVECs) in culture. The statistical significance of difference was analyzed by one-way analysis of variance (ANOVA) and Student's t-test using GraphPad 5 software. Increased vascularization in CAM, increased endothelial sprouting in rat aortic rings in culture, and increased expression of CD31 and E-selectin suggested a possible angiogenic effect of sarcosine. Sarcosine modulated expression of angiogenic growth factors such as vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF). In ECs in culture LY294002, an inhibitor of phosphatidylinositol-3-kinase (PI3K)/Akt pathway and rapamycin, an inhibitor of mammalian target of rapamycin (mTOR) reversed the effect of sarcosine. Further, sarcosine induced upregulation and activation of Akt in HUVECs.
    CONCLUSIONS:
    These results suggest that sarcosine modulates EC function relevant to angiogenesis through modulation of PI3K/Akt/mTOR pathway.
    In vivo:
    Anticancer Res. 2015 Feb;35(2):1017-23.
    Improving the prediction of pathologic outcomes in patients undergoing radical prostatectomy: the value of prostate cancer antigen 3 (PCA3), prostate health index (phi) and sarcosine.[Pubmed: 25667489]
    Several efforts have been made to find biomarkers that could help clinicians to preoperatively determine prostate cancer (PCa) pathological characteristics and choose the best therapeutic approach, avoiding over-treatment. On this effort, prostate cancer antigen 3 (PCA3), prostate health index (phi) and Sarcosine have been presented as promising tools. We evaluated the ability of these biomarkers to predict the pathologic PCa characteristics within a prospectively collected contemporary cohort of patients who underwent radical prostatectomy (RP) for clinically localized PCa at a single high-volume Institution.
    METHODS AND RESULTS:
    The prognostic performance of PCA3, phi and Sarcosine were evaluated in 78 patients undergoing RP for biopsy-proven PCa. Receiver operating characteristic (ROC) curve analyses tested the accuracy (area under the curve (AUC)) in predicting PCa pathological characteristics. Decision curve analyses (DCA) were used to assess the clinical benefit of the three biomarkers. We found that PCA3, phi and Sarcosine levels were significantly higher in patients with tumor volume (TV)≥0.5 ml, pathologic Gleason sum (GS)≥7 and pT3 disease (all p-values≤0.01). ROC curve analysis showed that phi is an accurate predictor of high-stage (AUC 0.85 [0.77-0.93]), high-grade (AUC 0.83 [0.73-0.93]) and high-volume disease (AUC 0.94 [0.88-0.99]). Sarcosine showed a comparable AUC (0.85 [0.76-0.94]) only for T3 stage prediction, whereas PCA3 score showed lower AUCs, ranging from 0.74 (for GS) to 0.86 (for TV).
    CONCLUSIONS:
    PCA3, phi and Sarcosine are predictors of PCa characteristics at final pathology. Successful clinical translation of these findings would reduce the frequency of surveillance biopsies and may enhance acceptance of active surveillance (AS).
    Neuroscience. 2014 Jun 20;271:160-9.
    Sarcosine preconditioning induces ischemic tolerance against global cerebral ischemia.[Pubmed: 24797328]
    Brain ischemic tolerance is an endogenous protective mechanism activated by a preconditioning stimulus that is closely related to N-methyl-d-aspartate receptor (NMDAR). Glycine transporter type 1 (GlyT-1) inhibitors potentiate NMDAR and suggest an alternative strategy for brain preconditioning.
    METHODS AND RESULTS:
    The aim of this work was to evaluate the effects of brain preconditioning induced by sarcosine, a GlyT-1 inhibitor, against global cerebral ischemia and its relation to NMDAR. Sarcosine was administered over 7 days (300 or 500 mg/kg/day, ip) before the induction of a global cerebral ischemia model in Wistar rats (male, 8-week-old). It was observed that sarcosine preconditioning reduced cell death in rat hippocampi submitted to cerebral ischemia. Hippocampal levels of glycine were decreased in sarcosine-treated animals, which was associated with a reduction of [(3)H] glycine uptake and a decrease in glycine transporter expression (GlyT-1 and GlyT-2). The expression of glycine receptors and the NR1 and NR2A subunits of NMDAR were not affected by sarcosine preconditioning. However, sarcosine preconditioning reduced the expression of the NR2B subunits of NMDAR.
    CONCLUSIONS:
    In conclusion, these data demonstrate that sarcosine preconditioning induces ischemic tolerance against global cerebral ischemia and this neuroprotective state is associated with changes in glycine transport and reduction of NR2B-containing NMDAR expression.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 11.2246 mL 56.123 mL 112.246 mL 224.4921 mL 280.6151 mL
    5 mM 2.2449 mL 11.2246 mL 22.4492 mL 44.8984 mL 56.123 mL
    10 mM 1.1225 mL 5.6123 mL 11.2246 mL 22.4492 mL 28.0615 mL
    50 mM 0.2245 mL 1.1225 mL 2.2449 mL 4.4898 mL 5.6123 mL
    100 mM 0.1122 mL 0.5612 mL 1.1225 mL 2.2449 mL 2.8062 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    鸢尾黄素-7-O-葡萄糖基-4'-O-葡萄糖苷; Tectorigenin-7-O-beta-glucosyl-4'-O-beta-glucoside CFN95605 848128-32-5 C28H32O16 = 624.6 10mg QQ客服:1413575084
    唐松草酚定; Thalifendine CFN91786 18207-71-1 C19H16NO4 = 322.33 5mg QQ客服:2159513211
    2-Hydroxy-3-methoxybenzoic acid glucose ester; 2-Hydroxy-3-methoxybenzoic acid glucose ester CFN89113 172377-87-6 C14H18O9 = 330.28 5mg QQ客服:1457312923
    滨蓟黄甙; Cirsimarin CFN96507 13020-19-4 C23H24O11 = 476.43 5mg QQ客服:1457312923

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