7,8-二羟基升麻醇

7,8-Didehydrocimigenol

	产品编号	CFN92381
	CAS编号	150972-72-8
	分子式 = 分子量	C₃₀H₄₆O₅ = 486.7
	产品纯度	>=98%
	物理属性	Cryst.
	化合物类型	Triterpenoids
	植物来源	The roots of Cimicifuga foetida L.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
7,8-二羟基升麻醇	CFN92381	150972-72-8	1mg	QQ客服：2159513211
7,8-二羟基升麻醇	CFN92381	150972-72-8	5mg	QQ客服：2159513211
7,8-二羟基升麻醇	CFN92381	150972-72-8	10mg	QQ客服：2159513211
7,8-二羟基升麻醇	CFN92381	150972-72-8	20mg	QQ客服：2159513211

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Leibniz Institute of Plant Biochemistry (Germany)

Periyar University (India)

Regional Crop Research Institute (Korea)

Deutsches Krebsforschungszentrum (Germany)

Helmholtz Zentrum München (Germany)

Yale University (USA)

The Australian National University (Australia)

Imperial College London (United Kingdom)

National Cancer Center Research Institute (Japan)

University of Minnesota (USA)

Universiti Malaysia Pahang (Malaysia)

Lund University (Sweden)

John Innes Centre (United Kingdom)

Research Unit Molecular Epigenetics (MEG) (Germany)

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Description:

7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-γ in EC inhibits NF-kB activity of TNF-α-activated EC which leads to selective inhibition of VCAM-1 expression.

Targets:

TNF-α | PPAR | NF-kB | ERK | Akt | IkB | IKK

In vitro:

Food Chem Toxicol. 2011 Jan;49(1):166-72.

7,8-didehydrocimigenol from Cimicifugae rhizoma inhibits TNF-α-induced VCAM-1 but not ICAM-1expression through upregulation of PPAR-γ in human endothelial cells.[Pubmed: 20946932]

Activators of PPAR have been demonstrated to inhibit the induction of VCAM-1 but not ICAM-1 in human endothelial cells (EC). During the screening of anti-inflammatory activity of traditional herbs, we found 7,8-Didehydrocimigenol (7,8-DHC), one of active triterpenoids of Cimicifugae rhizoma (C. rhizoma) increases PPAR-γ expression in EC in a time- and dose-dependent manner.
METHODS AND RESULTS:
Therefore, we asked whether 7,8-Didehydrocimigenol selectively inhibits the expression of VCAM-1 but not ICAM-1 in TNF-α-activated EC via upregulation of PPAR-γ. Treatment with 7,8-Didehydrocimigenol or PPAR-γ agonists (GW1929, troglitazone) inhibited the expression of VCAM-1 but not ICAM-1. 7,8-Didehydrocimigenol significantly inhibited NF-kB activity via inhibition of phosphorylation of IkB and it also inhibited phosphorylation of ERK1/2 and Akt but not PKC. Finally, attachment of monocytes (U937) to EC by TNF-α was significantly reduced by 7,8-Didehydrocimigenol .
CONCLUSIONS:
These results indicate that upregualtion of PPAR-γ by 7,8-Didehydrocimigenol in EC inhibits NF-kB activity of TNF-α-activated EC which leads to selective inhibition of VCAM-1 expression. In addition, ERK1/2 and Akt signal pathways are involved in differential regulation by 7,8-Didehydrocimigenol. We concluded that 7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
24-epi-24-O-acetyl-7,8-didehydrohydroshengmanol-3-O-beta-D-xylopyranoside; 24-epi-24-O-acetyl-7,8-didehydrohydroshengmanol-3-O-beta-D-xylopyranoside	CFN95628	228251-25-0	C₃₇H₅₈O₁₁ = 678.9	5mg	QQ客服：2159513211
7,8-二羟基升麻醇; 7,8-Didehydrocimigenol	CFN92381	150972-72-8	C₃₀H₄₆O₅ = 486.7	5mg	QQ客服：1457312923
升麻酮; Cimigenol-3-one	CFN89138	31222-32-9	C₃₀H₄₆O₅ = 486.69	5mg	QQ客服：2056216494
升麻苷E; Cimiside E	CFN92974	154822-57-8	C₃₅H₅₄O₈ = 602.80	5mg	QQ客服：2056216494
25-脱氢升麻醇 3-O-beta-D-木糖苷; 25-Anhydrocimigenol 3-O-beta-D-xyloside	CFN92522	181765-11-7	C₃₅H₅₄O₈ = 602.8	5mg	QQ客服：3257982914
24-表-7,8-二羟基升麻醇 3-O-木糖苷; 24-epi-7,8-Didehydrocimigenol 3-xyloside	CFN95627	150972-77-3	C₃₅H₅₄O₉ = 618.8	5mg	QQ客服：3257982914
升麻环氧醇苷; Cimigenoside	CFN98340	27994-11-2	C₃₅H₅₆O₉ = 620.8	20mg	QQ客服：3257982914
升麻酮醇 3-O-alpha-L-拉伯糖苷; Cimiracemoside C	CFN98288	256925-92-5	C₃₅H₅₆O₉ = 620.8	10mg	QQ客服：215959384
升麻苷B; Cimiside B	CFN99637	152685-91-1	C₄₀H₆₄O₁₃ = 752.9	5mg	QQ客服：2056216494
Cimiracemoside D; Cimiracemoside D	CFN90649	290821-39-5	C₃₇H₅₈O₁₁ = 678.39	10mg	QQ客服：3257982914

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.0547 mL	10.2733 mL	20.5465 mL	41.0931 mL	51.3663 mL
5 mM	0.4109 mL	2.0547 mL	4.1093 mL	8.2186 mL	10.2733 mL
10 mM	0.2055 mL	1.0273 mL	2.0547 mL	4.1093 mL	5.1366 mL
50 mM	0.0411 mL	0.2055 mL	0.4109 mL	0.8219 mL	1.0273 mL
100 mM	0.0205 mL	0.1027 mL	0.2055 mL	0.4109 mL	0.5137 mL