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  • 裂叶苣荚莱内酯

    Santamarine

    裂叶苣荚莱内酯
    产品编号 CFN98667
    CAS编号 4290-13-5
    分子式 = 分子量 C15H20O3 = 248.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The roots of Dolomiaea souliei (Franch.) Shih
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    裂叶苣荚莱内酯 CFN98667 4290-13-5 1mg QQ客服:2159513211
    裂叶苣荚莱内酯 CFN98667 4290-13-5 5mg QQ客服:2159513211
    裂叶苣荚莱内酯 CFN98667 4290-13-5 10mg QQ客服:2159513211
    裂叶苣荚莱内酯 CFN98667 4290-13-5 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Subang Jaya Medical Centre (Malaysia)
  • University of Amsterdam (Netherlands)
  • Monash University Malaysia (Malaysia)
  • Massachusetts General Hospital (USA)
  • Monash University (Australia)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • Weizmann Institute of Science (Israel)
  • National Chung Hsing University (Taiwan)
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • Periyar University (India)
  • Warszawski Uniwersytet Medyczny (Poland)
  • University of Hertfordshire (United Kingdom)
  • Georgia Institute of Technology (USA)
  • Universidade do Porto (Portugal)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci.2021, 22(8):4211.
  • Molecules2022, 27(12):3903.
  • Food Funct.2022, D1FO03838A.
  • Curr Res Virol Sci.2022, 3:100019.
  • Biomed Pharmacother.2022, 145:112410.
  • Food and Fermentation Industries2018, 44(371)
  • Nat Prod Sci.2016, 22(2)
  • Front Pharmacol.2018, 9:236
  • Nat Commun.2021, 12(1):681.
  • SRM Institute of Sci&Tech2022, 34(1): 32-37
  • Pharmaceutics.2020, 12(9):882.
  • Sci Adv.2018, 4(10)
  • Molecules.2022, 27(5):1675
  • J Chromatogr B Analyt Technol Biomed Life Sci.2020, 1149:122123.
  • Mie University2019, 10076.
  • Phytother Res.2022, 10.1002:ptr.7592.
  • Biorxiv2019, 10.1101
  • Nutrients.2018, 10(12):E1998
  • J Ethnopharmacol.2024, 318:116863.
  • J Korean Soc Food Sci Nutr2023, 52(11):1101-1110
  • JOTCSA.2023, 10(4); 893-902.
  • Life Sci.2021, 286:120019.
  • QASCF2022, 14(4).
  • ...
  • 生物活性
    Description: Santamarine has significant anticancer activity, can inhibit L1210 cells because of its cytotoxic,cytostatic and blocking mitosis and reducing uptake of thymidine. Santamarine and reynosin show bactericidal activity against clinical strains of Mycobacterium tuberculosis.
    Targets: Caspase
    In vitro:
    Cancer Chemother Pharmacol. 2009 Jun;64(1):143-52.
    Anticancer activities of sesquiterpene lactones from Cyathocline purpurea in vitro.[Pubmed: 18998133]
    Cyathocline purpurea has been traditionally used to treat various diseases including cancers for many years. However, these applications of C. purpurea have not been supported by pharmacological investigation. The objective of this study is to investigate the anticancer activities of three main constituents such as santamarine, 9beta-acetoxycostunolide and 9beta-acetoxyparthenolide isolated from C. purpurea in vitro.
    METHODS AND RESULTS:
    Cell viability was determined by trypan blue exclusion and methylene blue assays. Colony formation was assessed by microtitration cloning assay. DNA synthesis was determined by tritiated thymidine incorporation assay. Cell cycle analysis was carried out by flow cytometry. Apoptosis was observed by DAPI staining assay and Caspase 3/7 activities was measured using Caspase-Glo 3/7 assay kit. Santamarine, 9beta-acetoxycostunolide and 9beta-acetoxyparthenolide inhibited the growth of L1210 murine leukaemia, CCRF-CEM human leukaemia, KB human nasopharyngeal carcinoma, LS174T human colon adenocarcinoma and MCF 7 human breast adenocarcinoma cells in vitro, with IC(50) in the range of 0.16-1.3 microg/mL. In L1210 model, santamarine and 9beta-acetoxycostunolide inhibited L1210 cell growth, colony formation and [(3)H]-thymidine incorporation in time- and concentration-dependent manners. Flow cytometry studies showed that santamarine and 9beta-acetoxycostunolide blocked L1210 cells in the G(2)/M phase of the cell cycle. DAPI staining and caspase activity assays showed santamarine and 9beta-acetoxycostunolide induced apoptosis and activated caspase 3 in L1210 cells.
    CONCLUSIONS:
    These results indicated that santamarine, 9beta-acetoxycostunolide and 9beta-acetoxyparthenolide exhibit significant anticancer activities in vitro. The inhibitory effects of santamarine and 9beta-acetoxycostunolide on L1210 cells are cytotoxic rather than just cytostatic. They block mitosis and reduce uptake of thymidine. The mechanism of the cytotoxicity of santamarine and 9beta-acetoxycostunolide to L1210 cells could be related to alkylation of the sulfhydryl enzymes involved in nucleic acids and protein synthesis, as previously found for other sesquiterpenes with the alpha-methylene-gamma-lactone moiety present in santamarine, 9beta-acetoxycostunolide and 9beta-acetoxyparthenolide. It may also be related to suppression of microtubular proteins. Santamarine and 9beta-acetoxycostunolide induced apoptosis of L1210 cells via activation of caspase 3.
    Pharmaceutical Biology, 2016, 14 May, 54(11):2623-8.
    Reynosin and santamarine: two sesquiterpene lactones from Ambrosia confertiflora with bactericidal activity against clinical strains of Mycobacterium tuberculosis[Reference: WebLink]
    Two sesquiterpene lactones (SQLs) with mycobactericidal activity were identified: Santamarine and reynosin.
    METHODS AND RESULTS:
    Reynosin was the most active compound, with a minimal bactericidal concentration (MBC) of 128 μg/mL against the H37Rv, 366-2009 and 104-2010 Mtb strains and a minimal inhibitory concentration (MIC) of 64, 64, 128, 128 and 128 μg/mL against the H37Rv, 104-2010, 63-2009, 366-2009 and 430-2010 Mtb strains, respectively. Santamarine had MBCs of 128 μg/mL against the H3Rv and 104-2010 Mtb strains and MICs of 128 μg/mL against the H37Rv, 366-2009 and 104-2010 Mtb strains. We also isolated 1,10-epoxyparthenolide but only showed mycobacteriostatic activity (MIC 128 μg/mL) against the Mtb strain. Compounds were tested against the L929 cell line and the calculated selectivity index was <1.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.0274 mL 20.1369 mL 40.2739 mL 80.5477 mL 100.6847 mL
    5 mM 0.8055 mL 4.0274 mL 8.0548 mL 16.1095 mL 20.1369 mL
    10 mM 0.4027 mL 2.0137 mL 4.0274 mL 8.0548 mL 10.0685 mL
    50 mM 0.0805 mL 0.4027 mL 0.8055 mL 1.611 mL 2.0137 mL
    100 mM 0.0403 mL 0.2014 mL 0.4027 mL 0.8055 mL 1.0068 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Alpha-山道年; Alpha-Santonin CFN90946 481-06-1 C15H18O3 = 246.30 20mg QQ客服:1457312923
    喘诺木烯内酯; Reynosin CFN98344 28254-53-7 C15H20O3 = 248.3 5mg QQ客服:2159513211
    裂叶苣荚莱内酯; Santamarine CFN98667 4290-13-5 C15H20O3 = 248.3 5mg QQ客服:2159513211
    8alpha-甲基丙烯酰氧基巴尔喀蒿烯内酯; 8alpha-Methacryloyloxybalchanin CFN97882 104021-39-8 C19H24O5 = 332.4 5mg QQ客服:2159513211
    8beta-顺芷酸喘诺木烯内酯; 8beta-Tigloyloxyreynosin CFN96917 80368-31-6 C20H26O5 = 346.42 5mg QQ客服:2056216494
    Pyrochamissanthin; Pyrochamissanthin CFN92705 41743-60-6 C15H20O3 = 248.3 5mg QQ客服:215959384

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