S-腺甙甲硫氨酸对甲苯磺酸盐

S-Adenosyl-L-methionine tosylate

	产品编号	CFN90074
	CAS编号	71914-80-2
	分子式 = 分子量	C₂₂H₃₀N₆O₈S₂ = 570.6
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Alkaloids
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产品名称	产品编号	CAS编号	包装	QQ客服
S-腺甙甲硫氨酸对甲苯磺酸盐	CFN90074	71914-80-2	1mg	QQ客服：1457312923
S-腺甙甲硫氨酸对甲苯磺酸盐	CFN90074	71914-80-2	5mg	QQ客服：1457312923
S-腺甙甲硫氨酸对甲苯磺酸盐	CFN90074	71914-80-2	10mg	QQ客服：1457312923
S-腺甙甲硫氨酸对甲苯磺酸盐	CFN90074	71914-80-2	20mg	QQ客服：1457312923

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Description:

S-adenosyl-L-methionine tosylate has a beneficial effect on the outcome of ischemic injury by reducing the blood-brain barrier (BBB) breakdown and neuronal death.

In vivo:

Brain Res Mol Brain Res. 1997 Feb;44(1):134-8.

Beneficial effects of S-adenosyl-L-methionine on blood-brain barrier breakdown and neuronal survival after transient cerebral ischemia in gerbils.[Pubmed: 9030707]

We have studied the beneficial effects of S-Adenosyl-L-methionine tosylate on blood-brain barrier (BBB) breakdown and neuronal survival after transient cerebral ischemia in gerbils.
METHODS AND RESULTS:
BBB breakdown experiments were performed in pentobarbital anesthetized gerbils subjected to 10 min of bilateral carotid artery occlusion and 6 h of reperfusion. For BBB breakdown measurements, S-adenosyl-L-methionine (120 mg/kg, i.p.) was administered to gerbils just after occlusion and thereafter every hour up to 5 h. Fluorometric measurements quantified the blood-brain permeability tracer, Evans blue (EB). S-adenosyl-L-methionine treatment significantly reduced the BBB breakdown as indicated by reduced levels of EB fluorescence. Neuronal count experiments were conducted in gerbils subjected to transient ischemia and 7 days of reperfusion. For neuronal count experiments S-adenosyl-L-methionine (15-120 mg/kg) was administered at 6 and 12 h after reperfusion, and twice each day thereafter for 7 days. S-adenosyl-L-methionine dose dependently protected the hippocampal CA1 neurons assessed by histopathological methods.
CONCLUSIONS:
S-adenosyl-L-methionine has a beneficial effect on the outcome of ischemic injury by reducing the BBB breakdown and neuronal death.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
S-腺甙甲硫氨酸对甲苯磺酸盐; S-Adenosyl-L-methionine tosylate	CFN90074	71914-80-2	C₂₂H₃₀N₆O₈S₂ = 570.6	5mg	QQ客服：1457312923
S-腺苷蛋氨酸; S-Adenosyl-L-Methtonine	CFN90075	17176-17-9	C₁₅H₂₂N₆O₅S = 398.44	20mg	QQ客服：1413575084
S-腺苷基-L-蛋氨碘盐; S-Adenosyl-L-Methionine iodide salt	CFN90076	3493-13-8	C₁₅H₂₃IN₆O₅S.I = 526.3	5mg	QQ客服：2056216494
Zarzissine; Zarzissine	CFN96195	160568-14-9	C₅H₅N₅ = 135.1	5mg	QQ客服：3257982914
鸟嘌呤核苷; Guanosine	CFN90925	118-00-3	C₁₀H₁₃N₅O₅ = 283.2	20mg	QQ客服：1413575084
2'-脱氧鸟苷; 2'-Deoxyguanosine	CFN91545	312693-72-4	C₁₀H₁₃N₅O₄ = 267.2	20mg	QQ客服：215959384
虫草素; Cordycepin	CFN98566	73-03-0	C₁₀H₁₃N₅O₃ = 251.24	20mg	QQ客服：215959384
腺苷；腺甙；腺嘌呤核苷 ; Adenosine	CFN98992	58-61-7	C₁₀H₁₃N₅O₄ = 267.2	20mg	QQ客服：3257982914
2'-脱氧腺苷; 2'-Deoxyadenosine	CFN91547	16373-93-6	C₁₀H₁₃N₅O₃ = 251.2	20mg	QQ客服：215959384
肌苷; Inosine	CFN93249	58-63-9	C₁₀H₁₂N₄O₅ = 268.2	20mg	QQ客服：2056216494

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.7525 mL	8.7627 mL	17.5254 mL	35.0508 mL	43.8135 mL
5 mM	0.3505 mL	1.7525 mL	3.5051 mL	7.0102 mL	8.7627 mL
10 mM	0.1753 mL	0.8763 mL	1.7525 mL	3.5051 mL	4.3814 mL
50 mM	0.0351 mL	0.1753 mL	0.3505 mL	0.701 mL	0.8763 mL
100 mM	0.0175 mL	0.0876 mL	0.1753 mL	0.3505 mL	0.4381 mL