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  • 鸟嘌呤核苷

    Guanosine

    鸟嘌呤核苷
    产品编号 CFN90925
    CAS编号 118-00-3
    分子式 = 分子量 C10H13N5O5 = 283.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The peels of Punica granatum L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    鸟嘌呤核苷 CFN90925 118-00-3 10mg QQ客服:2159513211
    鸟嘌呤核苷 CFN90925 118-00-3 20mg QQ客服:2159513211
    鸟嘌呤核苷 CFN90925 118-00-3 50mg QQ客服:2159513211
    鸟嘌呤核苷 CFN90925 118-00-3 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
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    IF=12.804(2019)

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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Acta Edulis Fungi2020, 27(02):63-76.
  • Front Pharmacol.2021, 12:690113.
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  • Microchemical Journal2023. 191:108938
  • Nutrients.2023, 15(6):1417.
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  • Chemistr of plant2016, 2016021195
  • Biomimetics (Basel).2022, 7(4):154.
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  • Front Plant Sci.2021, 12: 648426.
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  • ...
  • 生物活性
    Description: Guanosine and GMP show anticonvulsant properties, which may be related with antagonism of glutamate receptors; they also prevent seizures induced by quinolinic acid in mice.Guanosine protects against renal ischemic injury by replenishing GTP stores and preventing tubular apoptosis.
    Targets: GABA Receptor
    In vivo:
    Brain Res. 2000 May 2;864(1):40-3.
    Guanosine and GMP prevent seizures induced by quinolinic acid in mice.[Pubmed: 10793184]
    In the mammalian CNS, glutamate and GABA are the principal neurotransmitters mediating excitatory and inhibitory synaptic events, respectively, and have been implicated in the neurobiology of seizures. Guanine-based purines, including the nucleoside guanosine and the nucleotide GMP, have been shown to antagonize glutamatergic activity at the receptor level and the other purine nucleoside adenosine is a well-known modulator of seizure threshold.
    CONCLUSIONS:
    In the present study we investigated the anticonvulsant effect of i. p. guanosine and GMP against seizures induced by the glutamate agonist quinolinic acid (QA) or the GABA(A) antagonist picrotoxin in mice. Animals were pretreated with an i.p. injection of saline, guanosine or GMP 30 min before either an i.c.v. injection of 4 microliter QA (36.8 nmol) or a subcutaneous injection of picrotoxin (3.2 mg/kg). All animals pretreated with vehicle followed by QA or picrotoxin presented seizures, which were completely prevented by the NMDA antagonist MK-801 and the GABA agonist phenobarbital, respectively. Guanosine and GMP dose-dependently protected against QA-induced seizures, up to 70 and 80% at 7.5 mg/kg, with ED(50)=2. 6+/-0.4 and 1.7+/-0.6 mg/kg, respectively. Conversely, neither guanosine, GMP nor MK-801 affected picrotoxin-induced seizures, indicating some degree of specificity towards the glutamatergic system.
    CONCLUSIONS:
    This study suggests anticonvulsant properties of i.p. guanosine and GMP, which may be related with antagonism of glutamate receptors.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.5311 mL 17.6554 mL 35.3107 mL 70.6215 mL 88.2768 mL
    5 mM 0.7062 mL 3.5311 mL 7.0621 mL 14.1243 mL 17.6554 mL
    10 mM 0.3531 mL 1.7655 mL 3.5311 mL 7.0621 mL 8.8277 mL
    50 mM 0.0706 mL 0.3531 mL 0.7062 mL 1.4124 mL 1.7655 mL
    100 mM 0.0353 mL 0.1766 mL 0.3531 mL 0.7062 mL 0.8828 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    虫草素; Cordycepin CFN98566 73-03-0 C10H13N5O3 = 251.24 20mg QQ客服:2159513211
    腺苷; 腺甙; 腺嘌呤核苷 ; Adenosine CFN98992 58-61-7 C10H13N5O4 = 267.2 20mg QQ客服:215959384
    2'-脱氧腺苷; 2'-Deoxyadenosine CFN91547 16373-93-6 C10H13N5O3 = 251.2 20mg QQ客服:3257982914
    肌苷; Inosine CFN93249 58-63-9 C10H12N4O5 = 268.2 20mg QQ客服:2159513211
    咖啡因; Caffeine CFN99004 58-08-2 C8H10N4O2 = 194.2 20mg QQ客服:2056216494
    1,3,9-三甲基尿酸; 1,3,9-Trimethyluric acid CFN89099 7464-93-9 C8H10N4O3 = 210.19 5mg QQ客服:2056216494
    肌苷酸二钠盐; 5'-IMPdisodium salt CFN80067 4691-65-0 C10H11N4Na2O8P = 392.17 5mg QQ客服:215959384
    巴豆苷; 异鸟苷; Crotonoside CFN99524 1818-71-9 C10H13N5O5 = 283.24 20mg QQ客服:3257982914
    次黄嘌呤 ; Hypoxanthine CFN96592 68-94-0 C5H4N4O = 136.11 20mg QQ客服:2159513211
    3-甲基黄嘌呤; 3-Methylxanthine CFN95087 1076-22-8 C6H6N4O2 = 166.1 20mg QQ客服:1457312923

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