洛克米兰醇

Rocaglaol

	产品编号	CFN99609
	CAS编号	147059-46-9
	分子式 = 分子量	C₂₆H₂₆O₆ = 434.5
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Phenols
	植物来源	The herbs of Aglaia odorata Lour
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
洛克米兰醇	CFN99609	147059-46-9	1mg	QQ客服：2056216494
洛克米兰醇	CFN99609	147059-46-9	5mg	QQ客服：2056216494
洛克米兰醇	CFN99609	147059-46-9	10mg	QQ客服：2056216494
洛克米兰醇	CFN99609	147059-46-9	20mg	QQ客服：2056216494

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Technical University of Denmark (Denmark)

Srinakharinwirot University (Thailand)

Universidade Federal de Goias (UFG) (Brazil)

University of Virginia (USA)

National Cancer Center Research Institute (Japan)

Johannes Gutenberg University Mainz (JGU) (Germany)

Hamdard University (India)

University of Bordeaux (France)

China Medical University (Taiwan)

Shanghai University of TCM (China)

University of Perugia (Italy)

Universidad Veracuzana (Mexico)

University Medical Center Mainz (Germany)

John Innes Centre (United Kingdom)

More...

Description:

Rocaglaol is a potent anticancer drug that induces apoptosis of LNCaP cells through the mitochondrial pathway and its G2/M-phase cell cycle arrest is associated with the down-regulation of Cdc25C and the dephosphorylation of Cdc2. Rocaglaol can reduce tissue inflammation and neuronal cell death by inhibiting NF-kappa B and AP-1 signaling, resulting in significant neuroprotection in animal models of neurodegeneration. Rocaglaol derivatives can prevent or to limit the cardiotoxicity of an antineoplastic agent, in particular to prevent or to limit the apoptosis of cardiomyocytes induced by such agent. Rocaglaol, pyrimidinone and aglaiastatin are potent inhibitors of the growth of K--cells, with IC50 values of 1-10 ng/mL, and induce normal morphology in K--cells at 10-30 ng/mL, they also specifically inhibit protein synthesis.

Targets:

Bcl-2/Bax | TNF-α | AP-1 | NF-kB | Cdc2

In vitro:

J Med Chem. 2009 Aug 27;52(16):5176-87.

Synthetic analogue of rocaglaol displays a potent and selective cytotoxicity in cancer cells: involvement of apoptosis inducing factor and caspase-12.[Pubmed: 19655762]

Flavaglines constitute a family of natural anticancer compounds.
METHODS AND RESULTS:
We present here 3 (FL3), the first synthetic flavagline that inhibits cell proliferation and viability (IC(50) approximately 1 nM) at lower doses than did the parent compound, racemic Rocaglaol.

US 20120101153 A1[P]. 2012.

ROCAGLAOL DERIVATIVES AS CARDIOPROTECTANT AGENTS AND AS ANTINEOPLASTIC AGENTS[Reference: WebLink]

METHODS AND RESULTS:
The present invention discloses new Rocaglaol derivatives and the use of Rocaglaol derivatives to prevent or to limit the cardiotoxicity of an antineoplastic agent, in particular to prevent or to limit the apoptosis of cardiomyocytes induced by such agent.

J Nat Prod. 1996 Jul;59(7):650-2.

Cyclopentabenzofuran lignan protein synthesis inhibitors from Aglaia odorata.[Pubmed: 8759160 ]

METHODS AND RESULTS:
In the course of screening for Ras function inhibitors, Rocaglaol (1) and the related compounds, the known pyrimidinone (2) and the novel aglaiastatin (3), were isolated from a CHCI3 extract of the leaves of Aglaia odorata. The structure of 3 was elucidated as a novel cyclopentabenzofuran on the basis of its NMR spectroscopic data and by X-ray crystallographic analysis.
CONCLUSIONS:
These compounds (1-3) were potent inhibitors of the growth of K-ras-NRK cells, with IC50 values of 1-10 ng/mL, and induced normal morphology in K-ras-NRK cells at 10-30 ng/mL. They also specifically inhibited protein synthesis.Aglaiastatin (3) was slightly more potent than 1 and 2 in inhibiting cell growth. Aglaiastatin (3) reduced the amount of Ras, possibly by inhibiting its de novo synthesis.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
洛克米兰醇; Rocaglaol	CFN99609	147059-46-9	C₂₆H₂₆O₆ = 434.5	5mg	QQ客服：1413575084
Desmethylrocaglamide; Desmethylrocaglamide	CFN89458	146408-78-8	C₂₈H₂₉NO₇ = 491.53	5mg	QQ客服：215959384
洛克米兰酰胺; Rocaglamide	CFN97339	84573-16-0	C₂₉H₃₁NO₇ = 505.6	5mg	QQ客服：1413575084
3'-羟基洛克米兰酰胺; 3'-Hydroxyrocaglamide	CFN99875	189322-67-6	C₂₉H₃₁NO₈ = 521.6	5mg	QQ客服：215959384
3'-甲氧基罗米仔兰酰胺; 3'-Methoxyrocaglamide	CFN99876	189322-69-8	C₃₀H₃₃NO₈ = 535.6	5mg	QQ客服：1457312923
Dehydroaglaiastatin; Dehydroaglaiastatin	CFN99660	155595-93-0	C₃₁H₂₈N₂O₆ = 524.6	5mg	QQ客服：2056216494
3'-Hydroxydehydroaglaiastatin; 3'-Hydroxydehydroaglaiastatin	CFN89448	259143-58-3	C₃₁H₂₈N₂O₇ = 540.56	5mg	QQ客服：3257982914

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.3015 mL	11.5075 mL	23.015 mL	46.0299 mL	57.5374 mL
5 mM	0.4603 mL	2.3015 mL	4.603 mL	9.206 mL	11.5075 mL
10 mM	0.2301 mL	1.1507 mL	2.3015 mL	4.603 mL	5.7537 mL
50 mM	0.046 mL	0.2301 mL	0.4603 mL	0.9206 mL	1.1507 mL
100 mM	0.023 mL	0.1151 mL	0.2301 mL	0.4603 mL	0.5754 mL

洛克米兰醇

Rocaglaol

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