| In vitro: |
| China Journal of Chinese Materia Medica,2018-07. | | Action mechanism of Baihe Dihuang decoction on depression based on integrative pharmacology of traditional Chinese medicine.[Reference: WebLink] | The classical traditional Chinese medicine excellent prescriptions( c TCMe P) of Baihe Dihuang decoction can be used for the depression caused by a variety of causes,but at present,most of them are only in theoretical research or clinical research,and lack of research on their active ingredients and action mechanism.
METHODS AND RESULTS:
In this study,the integrative pharmacology of traditional Chinese medicine( TCMIP,www. tcmip. cn) was used to explore the active ingredients,targets and the mechanisms of Baihe Dihuang decoction.Based on the TCMIP,a total of 10 active ingredients were predicted,including 4 from Lilium brownii: 26-O-β-D-glucopyranosyl-3β,26-dihydroxy-Δ5-choleslen-16,22-dioxo-3-O-α-L-rhamnopyranosyl-( 1 →2)-β-D-glucopyranoside,regaloside D,brownioside and lilioside C; 6 from Radix Rehmannia: alanine,sucrose,strumaroside,adenosine,L-arginine and manninotriose. Fifty five targets and multiple biological processes and metabolic pathways such as purine metabolism,disorder of amino acid catabolism,neurotrophic factors,and estrogen signaling pathway were involved in the mechanism. These targets and pathways were consistent with the pathogenesis of depression in other literature,proving that TCMIP had high accuracy in predicting the action mechanism of TCM and compound prescriptions. In addition,the study also showed that Baihe Dihuang decoction had certain application value for the treatment of Parkinson' s disease,anti-tumor,and childhood acute leukemia.
CONCLUSIONS:
This study would provide a scientific basis for further studies on the mechanism of Baihe Dihuang decoction in the treatment of depression,and provide a new research idea for the study of c TCMe P. |
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