覆盆子酮葡萄糖苷

Raspberryketone glucoside

	产品编号	CFN93228
	CAS编号	38963-94-9
	分子式 = 分子量	C₁₆H₂₂O₇ = 326.34
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Phenols
	植物来源	The fruits of red raspberry (Rubus idaeus).
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
覆盆子酮葡萄糖苷	CFN93228	38963-94-9	10mg	QQ客服：1457312923
覆盆子酮葡萄糖苷	CFN93228	38963-94-9	20mg	QQ客服：1457312923
覆盆子酮葡萄糖苷	CFN93228	38963-94-9	50mg	QQ客服：1457312923
覆盆子酮葡萄糖苷	CFN93228	38963-94-9	100mg	QQ客服：1457312923

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Universidade de Franca (Brazil)

University of Virginia (USA)

Medical University of Gdansk (Poland)

The University of Newcastle (Australia)

University of Stirling (United Kingdom)

Kyoto University (Japan)

Kazusa DNA Research Institute (Japan)

Mendel University in Brno (Czech Republic)

Periyar University (India)

Anna University (India)

University of Parma (Italy)

Ain Shams University (Egypt)

Hamdard University (India)

Semmelweis Unicersity (Hungary)

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Description:

Raspberry ketone glucoside has lasting effects for the inhibition of melanogenesis and various melanogenic factors after the degradation in the skin.

Targets:

In vitro:

Journal of Society of Cosmetic Chemists of Japan, 2001, 35(2):120-126.

Lasting Effect of Raspberry Ketone Glucoside on Whitening.[Reference: WebLink]

Tyrosinase is well-known as a key enzyme responsible for the production of melanin in melanocytes. It is also known that inflammatory reactions such as active oxygen species and melanogenic factors in the skin are induced by UV irradiation.
METHODS AND RESULTS:
The keys to suppress melanin synthesis are considered to be not only the inhibition of tyrosinase activity but also that of inflammatory reactions. Raspberryketone glucoside (RKG) in raspberry fruit (Rubus ideaeus) had the inhibitory effect on the melanin synthesis. As a result of an investigation with the glycosides that have similar structure of RKG at its glycoside moieties and alkyl chain, the structure of RKG was found to be suitable as an inhibitory factor on melanogenesis. RKG released raspberry ketone (RK) gradually after the reaction with both homogenated and desquamated cells of the stratum corneum. In addition to the inhibitory effect of melanin synthesis, RK also showed remarkable functions such as the scavenge of nitric oxide (NO) which was considered to induce pigmentation of human skin through activation of melanogenesis and the inhibition of the inflammation-related reactions such as production of superoxide anion and lipid peroxide.
CONCLUSIONS:
These data indicated that RKG had lasting effects for the inhibition of melanogenesis and various melanogenic factors after the degradation in the skin.

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.0643 mL	15.3214 mL	30.6429 mL	61.2858 mL	76.6072 mL
5 mM	0.6129 mL	3.0643 mL	6.1286 mL	12.2572 mL	15.3214 mL
10 mM	0.3064 mL	1.5321 mL	3.0643 mL	6.1286 mL	7.6607 mL
50 mM	0.0613 mL	0.3064 mL	0.6129 mL	1.2257 mL	1.5321 mL
100 mM	0.0306 mL	0.1532 mL	0.3064 mL	0.6129 mL	0.7661 mL