Info: Read More
  • 中药标准品生产商,产品定制服务
  • 补骨脂定

    Psoralidin

    补骨脂定
    产品编号 CFN98592
    CAS编号 18642-23-4
    分子式 = 分子量 C20H16O5 = 336.34
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The seeds of Psoralea corylifolia.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    补骨脂定 CFN98592 18642-23-4 10mg QQ客服:3257982914
    补骨脂定 CFN98592 18642-23-4 20mg QQ客服:3257982914
    补骨脂定 CFN98592 18642-23-4 50mg QQ客服:3257982914
    补骨脂定 CFN98592 18642-23-4 100mg QQ客服:3257982914
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Parma (Italy)
  • University of Bonn (Germany)
  • The Australian National University (Australia)
  • Weizmann Institute of Science (Israel)
  • University of Stirling (United Kingdom)
  • Sant Gadge Baba Amravati University (India)
  • Universitas islam negeri Jakarta (Indonesia)
  • Helmholtz Zentrum München (Germany)
  • University of Lodz (Poland)
  • Chang Gung University (Taiwan)
  • MTT Agrifood Research Finland (Finland)
  • Universidade Federal de Santa Catarina (Brazil)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • Chungnam National University (Korea)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Naunyn Schmiedebergs Arch Pharmacol.2021, 394(1):107-115.
  • Pak J Pharm Sci.2023, 36(1):51-57.
  • Pharmacognosy Journal2019, 11,6:1235-1241
  • Food Funct.2022, 13(23):12105-12120.
  • Food Bioscience2023, 56:103311.
  • Industrial Crops and Products2022, 188:115638
  • J Insect Sci.2020, 20(5):18.
  • The Japan Society for Analytical Chemistry2018, 67(4):201-206
  • Eur J Pharmacol.2022, 917:174744.
  • Front Pharmacol.2023, 14:1095083.
  • Journal of Ginseng Research2021, 3 June.
  • Front Immunol.2020, 11:598556.
  • J Food Sci Technol.2019, 56(5):2712-2720
  • Int J Mol Sci.2021, 22(17):9400.
  • Nutrients.2020, 12(11):3448.
  • Viruses2023, 15(6), 1377
  • Appl. Sci.2020, 10(5),1713.
  • Nutrients.2022, 14(16):3393.
  • Front Pharmacol.2022, 13:883475.
  • Food Chem.2020, 332:127412
  • Korean J. Food Preserv.2023, 30(4):663-668.
  • Pak J Pharm Sci.2019, 32(6):2879-2885
  • Phytomedicine.2015, 22(11):1027-36
  • ...
  • 生物活性
    Description: Psoralidin possesses potent antidepressant-like, anti-inflammatory, anticancer and chemopreventive properties. Psoralidin is a dual inhibitor of COX-2 and 5-LOX, it is also an agonist for both estrogen receptor (ER)α and ERβ agonist.Psoralidin inhibits LPS-induced iNOS expression via repressing Syk-mediated activation of PI3K-IKK-IκB signaling pathways, it induces reactive oxygen species (ROS)-dependent DNA damage and protective autophagy mediated by NOX4 in breast cancer cells.
    Targets: PI3K | Akt | NF-kB | Caspase | Estrogen receptor | COX | LOX | PGE | TNF-α | TGF-β/Smad | IL Receptor | Chk | ROS | NO | PI3K | NOS | IkB | 5-HT Receptor | IKK | Progestogen receptor
    In vitro:
    Phytomedicine. 2016 Aug 15;23(9):939-47.
    Psoralidin induced reactive oxygen species (ROS)-dependent DNA damage and protective autophagy mediated by NOX4 in breast cancer cells.[Pubmed: 27387402]
    Psoralidin (PSO), a natural phenolic coumarin, was reported to have anti-cancer activities. PSO induced reactive oxygen species (ROS) generation in cancer cells. The role of ROS in its anti-cancer effect remains unclear. This study was designed to investigate the potential roles of ROS in PSO-induced anti-cancer effect in MCF-7 breast cancer cells.
    METHODS AND RESULTS:
    Effect of PSO on cancer cell proliferation was determined by MTT assay. Comet assay was used to determine DNA damage. Protein expression was detected by Western blotting. Autophagic vacuoles were detected by monodansylcadaverine (MDC) staining. ROS generation was measured by fluorescent probe. NOX4 localization was determined by immunofluorescence staining. PSO treatment caused proliferation inhibition in time- and dose- dependent manners, which was partially reversed by N-acetyl cysteine (NAC) and diphenyleneiodonium (DPI). PSO induced DNA damage and increased protein expression of γ-H2AX, phosphorylation of ATM, ATR, Chk1, and Chk2. PSO induced autophagy as evidenced by the accumulation of autophagic vacuoles and alterations of autophagic protein expression. PSO-induced cell death was enhanced by autophagy inhibitor chloroquine (CQ). Furthermore, PSO treatment induced ROS formation, which was reversed by NAC or DPI pretreatment. The expression of NOX4 was significantly enhanced by PSO. Both NAC and DPI could reverse PSO-induced DNA damage and autophagic responses. In addition, silencing NOX4 by siRNA inhibited PSO-induced ROS generation, DNA damage, and autophagy.
    CONCLUSIONS:
    Taken together, these results showed that PSO induced DNA damage and protective autophagy mediated by ROS generation in a NOX4-dependent manner in MCF-7 cells.
    Molecules. 2012 May 29;17(6):6449-64.
    The coumarin psoralidin enhances anticancer effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).[Pubmed: 22643355 ]
    Coumarins are a very common type of secondary plant metabolites with a broad spectrum of biological activities. Psoralidin is a naturally occurring furanocoumarin isolated from Psoralea corylifolia possessing anticancer and chemopreventive properties. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) triggers apoptosis in cancer cells with no toxicity toward normal tissues. Endogenous TRAIL plays an important role in immune surveillance and defence against cancer cells. Coumarins can modulate TRAIL-mediated apoptosis in cancer cells.
    METHODS AND RESULTS:
    We examined the cytotoxic and apoptotic activities of Psoralidin in combination with TRAIL on HeLa cancer cells. The cytotoxicity was measured by MTT and LDH assays. The apoptosis was detected using annexin V-FITC staining and mitochondrial membrane potential was evaluated using DePsipher staining by fluorescence microscopy. Death receptor (TRAIL-R1/DR4 and TRAIL-R2/DR5) expression was analyzed using flow cytometry. Psoralidin enhanced TRAIL-induced apoptosis in HeLa cells through increased expression of TRAIL-R2 death receptor and depolarization of mitochondrial membrane potential.
    CONCLUSIONS:
    Our study indicated that Psoralidin augmented the anticancer effects of TRAIL and confirmed a potential use of coumarins in cancer chemoprevention.
    Planta Med. 1996 Aug;62(4):353-4.
    The cytotoxicity of psoralidin from Psoralea corylifolia.[Pubmed: 8792669]
    A cytotoxic coumestan derivative, psoralidin (1), was isolated from the seed of Psoralea corylifolia. The IC50 values of 1 against SNU-1 and SNU-16 carcinoma cell lines were 53 and 203 micrograms/ml, respectively, indicating cytotoxic activity against stomach carcinoma cell lines.
    In vivo:
    Biochem Pharmacol. 2011 Sep 1;82(5):524-34.
    Psoralidin, a dual inhibitor of COX-2 and 5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation.[Pubmed: 21669192]
    Psoralidin, a coumestan derivative isolated from the seed of Psoralea corylifolia, has been studied for anti-cancer and anti-bacterial properties. However, little is known regarding its effects on IR-induced pulmonary inflammation. The aim of this study is to investigate mechanisms of IR-induced inflammation and to examine therapeutic mechanisms of Psoralidin in human normal lung fibroblasts and mice.
    METHODS AND RESULTS:
    Here, we demonstrated that IR-induced ROS activated cyclooxygenases-2 (COX-2) and 5-lipoxygenase (5-LOX) pathway in HFL-1 and MRC-5 cells. Psoralidin inhibited the IR-induced COX-2 expression and PGE(2) production through regulation of PI3K/Akt and NF-κB pathway. Also, Psoralidin blocked IR-induced LTB(4) production, and it was due to direct interaction of Psoralidin and 5-lipoxygenase activating protein (FLAP) in 5-LOX pathway. IR-induced fibroblast migration was notably attenuated in the presence of Psoralidin. Moreover, in vivo results from mouse lung indicate that Psoralidin suppresses IR-induced expression of pro-inflammatory cytokines (TNF-α, TGF-β, IL-6 and IL-1 α/β) and ICAM-1.
    CONCLUSIONS:
    Taken together, our findings reveal a regulatory mechanism of IR-induced pulmonary inflammation in human normal lung fibroblast and mice, and suggest that Psoralidin may be useful as a potential lead compound for development of a better radiopreventive agent against radiation-induced normal tissue injury.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.9732 mL 14.8659 mL 29.7318 mL 59.4636 mL 74.3295 mL
    5 mM 0.5946 mL 2.9732 mL 5.9464 mL 11.8927 mL 14.8659 mL
    10 mM 0.2973 mL 1.4866 mL 2.9732 mL 5.9464 mL 7.433 mL
    50 mM 0.0595 mL 0.2973 mL 0.5946 mL 1.1893 mL 1.4866 mL
    100 mM 0.0297 mL 0.1487 mL 0.2973 mL 0.5946 mL 0.7433 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    甘草芳香豆素; Licoarylcoumarin CFN95072 125709-31-1 C21H20O6 = 368.4 5mg QQ客服:1413575084
    考迈斯托醇; Coumestrol CFN96040 479-13-0 C15H8O5 = 268.2 10mg QQ客服:1457312923
    4'-甲氧基香豆雌酚 ; 4'-O-Methylcoumestrol CFN96922 1690-62-6 C16H10O5 = 282.25 5mg QQ客服:215959384
    去甲基蟛蜞内酯; Demethylwedelolactone CFN90521 6468-55-9 C15H8O7 = 300.21 20mg QQ客服:1413575084
    蟛蜞菊内脂; Wedelolactone CFN98857 524-12-9 C16H10O7 = 314.3 20mg QQ客服:1457312923
    异去甲蟛蜞菊内脂; Isodemethylwedelolacton CFN90625 350681-33-3 C15H8O7 = 300.22 20mg QQ客服:3257982914
    补骨脂定; Psoralidin CFN98592 18642-23-4 C20H16O5 = 336.34 20mg QQ客服:2056216494
    新甘草酚; Neoglycyrol CFN90792 23013-84-5 C21H18O6 = 366.4 10mg QQ客服:1457312923
    甘草香豆素; Glycycoumarin CFN89408 94805-82-0 C21H20O6 = 368.37 10mg QQ客服:215959384
    格里西轮; Glycyrin CFN89404 66056-18-6 C22H22O6 = 382.40 5mg QQ客服:215959384

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产