野黑樱苷

Prunasin

	产品编号	CFN97566
	CAS编号	99-18-3
	分子式 = 分子量	C₁₄H₁₇NO₆ = 295.3
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Alkaloids
	植物来源	The leaves of Perilla frutescens
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
野黑樱苷	CFN97566	99-18-3	1mg	QQ客服：3257982914
野黑樱苷	CFN97566	99-18-3	5mg	QQ客服：3257982914
野黑樱苷	CFN97566	99-18-3	10mg	QQ客服：3257982914
野黑樱苷	CFN97566	99-18-3	20mg	QQ客服：3257982914

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Universite de Lille1 (France)

Deutsches Krebsforschungszentrum (Germany)

Indian Institute of Science (India)

Universit?t Basel (Switzerland)

University of Amsterdam (Netherlands)

Kyung Hee University (Korea)

Instituto Politécnico de Bragan?a (Portugal)

Mahidol University (Thailand)

Celltrion Chemical Research Institute (Korea)

Utrecht University (Netherlands)

Center for protein Engineering (CIP) (Belgium)

University of Toronto (Canada)

Weizmann Institute of Science (Israel)

Gyeongsang National University (Korea)

More...

Description:

Prunasin is a kind of enzyme inhibitors.

In vitro:

Hum Exp Toxicol. 1995 Nov;14(11):895-901.

Small-intestinal transfer mechanism of prunasin, the primary metabolite of the cyanogenic glycoside amygdalin.[Pubmed: 8588951]

1. The small-intestinal transfer of Prunasin (D-mandelo-nitrile-beta-D-glucoside), the primary metabolite of amygdalin which is not absorbed in the small intestine as such, was studied in rat jejunum and ileum in vitro.
METHODS AND RESULTS:
2. As shown by high pressure liquid chromatography, Prunasin is transferred essentially intact across the intestinal wall, without cleavage of the glycosidic bond and thus no formation of benzaldehyde or cyanide during the mucosal passage. 3. Only the jejunal transfer of Prunasin followed saturation kinetics (vmax = 1.6 mumol cm-1 min-1; KT = 460 mumol l-1) and exhibited a clearsodium-ion dependence. As indicated by the temperature dependence, only the jejunal mucosa-to-serosa transfer and the corresponding tissue uptake of Prunasin required apparently high activation energies. Transfer in the terminal ileum showed diffusion characteristics. 4. Jejunal methyl alpha-D-glucoside transfer was inhibited by the presence of Prunasin. Furthermore, the tissue uptake of methyl alpha-D-glucoside in rat jejunum was competitively inhibited by Prunasin.
CONCLUSIONS:
5. The results indicate that Prunasin is absorbed unmetabolised in the jejunum of the rat via the transport system of glucose.

In vivo:

J Agric Food Chem. 2001 Oct;49(10):5075-80.

Vicianin, prunasin, and beta-cyanoalanine in common vetch seed as sources of urinary thiocyanate in the rat.[Pubmed: 11600069]

When young rats were fed a diet containing common vetch seed for 1 month, they excreted in the urine approximately 7 times more thiocyanate than they had ingested. Vicianin, Prunasin, and beta-cyanoalanine were identified as principal dietary sources of the excreted thiocyanate.
METHODS AND RESULTS:
Vicianin was isolated by chromatography and crystallization. Its structure was confirmed by mass spectrometry and by identification of its monosaccharides and aglycon. Prunasin was identified chromatographically by HPLC. The combined seed content of vicianin (0.68 micromol/g) and Prunasin (0.16 micromol/g) corresponded to the cyanogen content of the seed (0.91 +/- 0.14 micromol/g; n = 7), determined as cyanide after autolysis. When vicianin was fed, the urinary thiocyanate output was 21% of the ingested amount of vicianin, whereas beta-cyanoalanine yielded a urinary thiocyanate output of < 0.2%.
CONCLUSIONS:
Calculations show that 73% of the thiocyanate can be derived from vicianin and Prunasin, with 27% derived from beta-cyanoalanine. High urinary output of thiocyanate has been associated with endocrine and neurological disorders.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
百脉根苷; (2RS)-Lotaustralin	CFN90968	1973415-50-7	C₁₁H₁₉NO₆ = 261.27	5mg	QQ客服：1413575084
Rhodiocyanoside A; Rhodiocyanoside A	CFN90973	168433-86-1	C₁₁H₁₇NO₆ = 259.26	5mg	QQ客服：1413575084
垂盆草苷; Sarmentosin	CFN97202	71933-54-5	C₁₁H₁₇NO₇ = 275.3	5mg	QQ客服：1413575084
Sutherlandin trans-p-coumarate; Sutherlandin trans-p-coumarate	CFN98399	315236-68-1	C₂₀H₂₃NO₉ = 421.4	5mg	QQ客服：2056216494
对羟基苯乙腈 ; 4-Hydroxyphenylacetonitrile	CFN96596	14191-95-8	C₈H₇NO = 133.15	5mg	QQ客服：2159513211
野黑樱苷; Prunasin	CFN97566	99-18-3	C₁₄H₁₇NO₆ = 295.3	5mg	QQ客服：1457312923
紫杉氰醣苷; Taxiphyllin	CFN98070	21401-21-8	C₁₄H₁₇NO₇ = 311.3	5mg	QQ客服：1413575084
扁桃苷; 苦杏仁甙; Amygdalin	CFN98373	29883-15-6	C₂₀H₂₇NO₁₁ = 457.4	20mg	QQ客服：215959384

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.3864 mL	16.9319 mL	33.8639 mL	67.7277 mL	84.6597 mL
5 mM	0.6773 mL	3.3864 mL	6.7728 mL	13.5455 mL	16.9319 mL
10 mM	0.3386 mL	1.6932 mL	3.3864 mL	6.7728 mL	8.466 mL
50 mM	0.0677 mL	0.3386 mL	0.6773 mL	1.3546 mL	1.6932 mL
100 mM	0.0339 mL	0.1693 mL	0.3386 mL	0.6773 mL	0.8466 mL

野黑樱苷

Prunasin

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