野黑樱苷
Prunasin
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 野黑樱苷 |
CFN97566 |
99-18-3 |
1mg |
QQ客服：1413575084 |
| 野黑樱苷 |
CFN97566 |
99-18-3 |
5mg |
QQ客服：1413575084 |
| 野黑樱苷 |
CFN97566 |
99-18-3 |
10mg |
QQ客服：1413575084 |
| 野黑樱苷 |
CFN97566 |
99-18-3 |
20mg |
QQ客服：1413575084 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
University of Toronto (Canada)
VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
Universidad de Buenos Aires (Argentina)
Wroclaw Medical University (Poland)
Medizinische Universit?t Wien (Austria)
Institute of Chinese Materia Medica (China)
Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
Worcester Polytechnic Institute (USA)
Mahatma Gandhi University (India)
Siksha O Anusandhan University (India)
University of Melbourne (Australia)
Chungnam National University (Korea)
Max Rubner-Institut (MRI) (Germany)
National Cancer Institute (USA)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
| Description: |
Prunasin is a kind of enzyme inhibitors.
|
| In vitro: |
| Hum Exp Toxicol. 1995 Nov;14(11):895-901. | | Small-intestinal transfer mechanism of prunasin, the primary metabolite of the cyanogenic glycoside amygdalin.[Pubmed: 8588951] |
1. The small-intestinal transfer of Prunasin (D-mandelo-nitrile-beta-D-glucoside), the primary metabolite of amygdalin which is not absorbed in the small intestine as such, was studied in rat jejunum and ileum in vitro.
METHODS AND RESULTS:
2. As shown by high pressure liquid chromatography, Prunasin is transferred essentially intact across the intestinal wall, without cleavage of the glycosidic bond and thus no formation of benzaldehyde or cyanide during the mucosal passage. 3. Only the jejunal transfer of Prunasin followed saturation kinetics (vmax = 1.6 mumol cm-1 min-1; KT = 460 mumol l-1) and exhibited a clearsodium-ion dependence. As indicated by the temperature dependence, only the jejunal mucosa-to-serosa transfer and the corresponding tissue uptake of Prunasin required apparently high activation energies. Transfer in the terminal ileum showed diffusion characteristics.
4. Jejunal methyl alpha-D-glucoside transfer was inhibited by the presence of Prunasin. Furthermore, the tissue uptake of methyl alpha-D-glucoside in rat jejunum was competitively inhibited by Prunasin.
CONCLUSIONS:
5. The results indicate that Prunasin is absorbed unmetabolised in the jejunum of the rat via the transport system of glucose. |
|
| In vivo: |
| J Agric Food Chem. 2001 Oct;49(10):5075-80. | | Vicianin, prunasin, and beta-cyanoalanine in common vetch seed as sources of urinary thiocyanate in the rat.[Pubmed: 11600069] | When young rats were fed a diet containing common vetch seed for 1 month, they excreted in the urine approximately 7 times more thiocyanate than they had ingested. Vicianin, Prunasin, and beta-cyanoalanine were identified as principal dietary sources of the excreted thiocyanate.
METHODS AND RESULTS:
Vicianin was isolated by chromatography and crystallization. Its structure was confirmed by mass spectrometry and by identification of its monosaccharides and aglycon. Prunasin was identified chromatographically by HPLC. The combined seed content of vicianin (0.68 micromol/g) and Prunasin (0.16 micromol/g) corresponded to the cyanogen content of the seed (0.91 +/- 0.14 micromol/g; n = 7), determined as cyanide after autolysis. When vicianin was fed, the urinary thiocyanate output was 21% of the ingested amount of vicianin, whereas beta-cyanoalanine yielded a urinary thiocyanate output of < 0.2%.
CONCLUSIONS:
Calculations show that 73% of the thiocyanate can be derived from vicianin and Prunasin, with 27% derived from beta-cyanoalanine. High urinary output of thiocyanate has been associated with endocrine and neurological disorders. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
3.3864 mL |
16.9319 mL |
33.8639 mL |
67.7277 mL |
84.6597 mL |
| 5 mM |
0.6773 mL |
3.3864 mL |
6.7728 mL |
13.5455 mL |
16.9319 mL |
| 10 mM |
0.3386 mL |
1.6932 mL |
3.3864 mL |
6.7728 mL |
8.466 mL |
| 50 mM |
0.0677 mL |
0.3386 mL |
0.6773 mL |
1.3546 mL |
1.6932 mL |
| 100 mM |
0.0339 mL |
0.1693 mL |
0.3386 mL |
0.6773 mL |
0.8466 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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