原藜芦碱

Protoveratrine A

	产品编号	CFN98521
	CAS编号	143-57-7
	分子式 = 分子量	C₄₁H₆₃NO₁₄ = 793.94
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Alkaloids
	植物来源	The roots of Veratrum nigrum L.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
原藜芦碱	CFN98521	143-57-7	1mg	QQ客服：1457312923
原藜芦碱	CFN98521	143-57-7	5mg	QQ客服：1457312923
原藜芦碱	CFN98521	143-57-7	10mg	QQ客服：1457312923
原藜芦碱	CFN98521	143-57-7	20mg	QQ客服：1457312923

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Description:

Protoveratrine A has anti-hypertensive action, it has some effects on cardiovascular and respiratory systems in rats in reducing the blood pressure and heart rate,prolonging the QTc interval,decreasing the respiratory rate and increasing the respiratory width. Protoveratrine A can increase K + uptake from frog skeletal muscle and cause this tissue to release more calcium (Ca ++ ). Protoveratrine A seems to involve at least in part an inhibition of dopaminergic neuron activity, it enhances the release of acetylcholine from the nerve terminals during the resting period and at low frequency of stimulation.

Targets:

Calcium Channel | Potassium Channel

In vitro:

J. Pharm. Pharmacol. 1959, 11(S1):176-84.

THE EFFECT OF PROTOVERATRINE A ON POTASSIUM AND CALCIUM ION MOVEMENTS IN MUSCLE AND NERVE.[Reference: WebLink]

The effects of Protoveratrine A on the efflux of potassium ions (K+) from frog and rat skeletal muscle and the isolated electrically driven rat heart have been studied.
METHODS AND RESULTS:
No effect was seen upon the rate of efflux from skeletal muscle but that from the heart was increased. Protoveratrine A increases K+ uptake from frog skeletal muscle and causes this tissue to release more calcium (Ca++). There was no increase in Ca++ release from lobster nerve treated with Protoveratrine A. The theoretical implications of these findings are discussed.

In vivo:

Toxicon. 1983;21(4):503-14.

Potentiation by crotamine of the depolarizing effects of batrachotoxin, protoveratrine A and grayanotoxin I on the rat diaphragm.[Pubmed: 6312634]

The interactions between crotamine and tetrodotoxin and group II sodium channel toxins, including batrachotoxin, protoveratrine A and grayanotoxin I, were studied on the rat diaphragm muscle.
METHODS AND RESULTS:
When the diaphragm was pretreated with 0.1 micrograms crotamine/ml for 45 min (a condition known to depolarize the muscle by less than 3 mV, which is only 20% of the maximal depolarization induced by a saturating concentration of crotamine), the rate of depolarization by group II toxins was markedly enhanced and the time to reach the steady state depolarization was greatly shortened. The maximal depolarizations induced by each of the group II toxins, however, were not increased. Pretreatment with saturating concentrations of crotamine also caused no change of the steady state depolarization induced by batrachotoxin or grayanotoxin I. Moreover, pretreatment of the diaphragm with a high concentration of grayanotoxin I, whose effect is reversible, did not impede the depolarizing effect of crotamine. Tetrodotoxin restored the membrane potential, depolarized by crotamine, with 50% restoration at a concentration of 16 ng/ml, no matter whether a high (20 micrograms/ml) or a low (2 micrograms/ml) concentration of crotamine were used.
CONCLUSIONS:
The above results indicate that there is no competition between crotamine and group II toxins or between crotamine and tetrodotoxin. However, crotamine may affect the binding of group II toxins allosterically, increasing their affinity although the intrinsic activity may not be changed.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
梭砂贝母碱; Hupehenine	CFN90475	98243-57-3	C₂₇H₄₅NO₂ = 415.65	20mg	QQ客服：215959384
西贝碱; Sipeimine	CFN99711	61825-98-7	C₂₇H₄₃NO₃ = 429.64	20mg	QQ客服：3257982914
西贝母碱苷; Edpetiline	CFN90883	32685-93-1	C₃₃H₅₃NO₈ = 591.8	20mg	QQ客服：2159513211
贝母素甲; Peimine	CFN99996	23496-41-5	C₂₇H₄₅NO₃ = 431.66	20mg	QQ客服：3257982914
贝母素乙; Peiminine	CFN99997	18059-10-4	C₂₇H₄₃NO₃ = 429.64	20mg	QQ客服：2056216494
原藜芦碱; Protoveratrine A	CFN98521	143-57-7	C₄₁H₆₃NO₁₄ = 793.94	5mg	QQ客服：2159513211
乙酸阿比特龙酯; Abiraterone Acetate	CFN90022	154229-18-2	C₂₆H₃₃NO₂ = 391.55	5mg	QQ客服：2159513211

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.2595 mL	6.2977 mL	12.5954 mL	25.1908 mL	31.4885 mL
5 mM	0.2519 mL	1.2595 mL	2.5191 mL	5.0382 mL	6.2977 mL
10 mM	0.126 mL	0.6298 mL	1.2595 mL	2.5191 mL	3.1489 mL
50 mM	0.0252 mL	0.126 mL	0.2519 mL	0.5038 mL	0.6298 mL
100 mM	0.0126 mL	0.063 mL	0.126 mL	0.2519 mL	0.3149 mL

原藜芦碱

Protoveratrine A

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