重楼皂苷VI

Polyphyllin VI

	产品编号	CFN99954
	CAS编号	55916-51-3
	分子式 = 分子量	C₃₉H₆₂O₁₃ = 738.91
	产品纯度	>=98%
	物理属性	White cryst.
	化合物类型	Steroids
	植物来源	The rhizomes of Paris yunnanensis Franch.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
重楼皂苷VI	CFN99954	55916-51-3	10mg	QQ客服：215959384
重楼皂苷VI	CFN99954	55916-51-3	20mg	QQ客服：215959384
重楼皂苷VI	CFN99954	55916-51-3	50mg	QQ客服：215959384
重楼皂苷VI	CFN99954	55916-51-3	100mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Description:

Polyphyllin VI and polyphyllin VII possess anti-cancer activities, they exhibits strong inhibitory effects on lung cancer cell growth in vitro and in vivo by inducing G2/M cell cycle arrest and triggering apoptosis.

Targets:

p53 | PARP | Caspase

In vitro:

Phytother Res. 2015 Oct;29(10):1568-76.

Anti-lung Cancer Effects of Polyphyllin VI and VII Potentially Correlate with Apoptosis In Vitro and In Vivo.[Pubmed: 26272214]

Polyphyllin VI (PVI) and polyphyllin VII (PVII) derived from Paris polyphylla possess anti-cancer activities. However, the mechanisms for the anti-lung cancer effects of PVI and PVII remain poorly understood.
METHODS AND RESULTS:
In this study, PVI and PVII exhibited inhibitory effects on the proliferation of A549 and NCI-H1299 cells. PVI and PVII induced G2/M cell cycle arrest and triggered apoptosis. PVI and PVII upregulated the tumor suppressor protein p53 and downregulated cyclin B1. The two treatments significantly increased the expression levels of death receptor 3, death receptor 5, Fas, cleaved PARP, and cleaved caspase-3. Furthermore, PVI and PVII significantly inhibited the growth of A549 cells in vivo. The tumor inhibitory rates of PVI were 25.74%, 34.62%, and 40.43% at 2, 3, and 4 mg/kg, respectively, and those of PVII were 25.63%, 41.71%, and 40.41% at 1, 2, and 3 mg/kg, respectively. Finally, PVI and PVII regulated the expression of proteins related to the apoptotic pathway in A549 xenografts.
CONCLUSIONS:
In summary, PVI and PVII exhibited strong inhibitory effects on lung cancer cell growth in vitro and in vivo by inducing G2/M cell cycle arrest and triggering apoptosis.

In vivo:

World Chinese Journal of Digestology, 2014, 22(29):4393.

Polyphyllin VI inhibits colitis associated colorectal carcinogenesis in mice: Possible mechanisms[Reference: WebLink]

To investigate the effect of Polyphyllin VI(PPLⅥ) on colitis associated colorectal carcinogenesis in mice and the underlying mechanisms.
METHODS AND RESULTS:
Fifty male Institute of Cancer Research(ICR) mice were randomly divided into five groups: a model group, three PPLⅥ-treated groups and a control group. The mice in the model group and three PPLⅥ-treated groups were given a single intraperitoneal injection of 1,2-dimethylhydrazine(DMH) at a dose of 15 mg/kg body weight. One week later, the mice were treated with 2%(w/v) dextran sodium sulfate(DSS) in theirdrinking water for 1 wk. This was followed by no further treatment for 1 wk. After another 1 wk of 2% DSS treatment, normal water was given for an additional 15 weeks. At week 9, the mice in PPLⅥ-treated groups were intraperitoneally injected with PPLⅥ(2.5, 5.0 and 10.0 mg/kg, respectively) every 3 d, for 12 wk. All mice were sacrificed at week 20 by ether overdose and colon samples were collected for histopathological examinations and Western blot analysis. HE staining showed that the incidence of tumor formation was 90% in the mice treated with DMH/DSS; it decreased to 40%(4/10), 20%(2/10), and 10%(1/10) in mice treated with DMH/DSS plus 2.5, 5.0 and 10.0 mg/kg of PPLⅥ, respectively. PPLⅥ treatment increased the expression of cleaved Caspase3, Caspase9 and Bax and decreased the expression of Bcl-2 in colonic epithelial cells.
CONCLUSIONS:
PPLⅥ can inhibit DMH/DSS-induced colon tumor formation in ICR mice partly through inducing apoptosis of abnormal colonic epithelial cells via the intrinsic pathway of apoptosis.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
盾叶薯蓣皂苷I,盾叶新苷; Zingiberen newsaponin	CFN90832	91653-50-8	C₅₁H₈₂O₂₂ = 1047.2	5mg	QQ客服：215959384
重楼皂苷VII; Chonglou Saponin VII	CFN97162	68124-04-9	C₅₁H₈₂O₂₁ = 1031.2	20mg	QQ客服：2159513211
蒺藜皂苷D; Terrestrosin D	CFN90821	179464-23-4	C₅₀H₈₀O₂₃ = 1049.2	10mg	QQ客服：1413575084
刺蒺藜素; Tribulosin	CFN70451	79974-46-2	C₅₅H₉₀O₂₅ = 1151.3	5mg	QQ客服：1457312923
洋地黄皂苷，毛地黄皂苷; Digitonin	CFN92831	11024-24-1	C₅₆H₉₂O₂₉ = 1229.3	20mg	QQ客服：1413575084
重楼皂苷VI; Polyphyllin VI	CFN99954	55916-51-3	C₃₉H₆₂O₁₃ = 738.91	20mg	QQ客服：215959384
Mannioside A; Mannioside A	CFN99055	1038922-95-0	C₃₉H₆₂O₁₃ = 738.9	5mg	QQ客服：3257982914
麦冬皂苷Ra，麦冬皂苷1，麦冬苷元-3-O-新橙皮糖苷; Ophiogenin-3-O-alpha-L-rhaMnopyranosyl-(1->2)-beta-D-glucopyranoside	CFN90638	128502-94-3	C₃₉H₆₂O₁₄ = 754.9	10mg	QQ客服：1457312923
天冬宁B; Shatavarin IV	CFN70458	84633-34-1	C₄₅H₇₄O₁₇ = 887.1	5mg	QQ客服：1413575084
14-羟基麦冬皂苷C; 14-Hydroxy sprengerinin C	CFN90636	1111088-89-1	C₄₄H₇₀O₁₇ = 871.02	10mg	QQ客服：1413575084

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.3533 mL	6.7667 mL	13.5334 mL	27.0669 mL	33.8336 mL
5 mM	0.2707 mL	1.3533 mL	2.7067 mL	5.4134 mL	6.7667 mL
10 mM	0.1353 mL	0.6767 mL	1.3533 mL	2.7067 mL	3.3834 mL
50 mM	0.0271 mL	0.1353 mL	0.2707 mL	0.5413 mL	0.6767 mL
100 mM	0.0135 mL	0.0677 mL	0.1353 mL	0.2707 mL	0.3383 mL

重楼皂苷VI

Polyphyllin VI

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