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  • 远志酸

    Polygalacic acid

    远志酸
    产品编号 CFN99108
    CAS编号 22338-71-2
    分子式 = 分子量 C30H48O6 = 504.71
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The roots of Polygala tenuifolia Willd.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    远志酸 CFN99108 22338-71-2 1mg QQ客服:1457312923
    远志酸 CFN99108 22338-71-2 5mg QQ客服:1457312923
    远志酸 CFN99108 22338-71-2 10mg QQ客服:1457312923
    远志酸 CFN99108 22338-71-2 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Bordeaux (France)
  • Nanjing University of Chinese Medicine (China)
  • National Cancer Center Research Institute (Japan)
  • Copenhagen University (Denmark)
  • Istanbul University (Turkey)
  • Korea Institute of Oriental Medicine (Korea)
  • Monash University (Australia)
  • University of Illinois (USA)
  • Utrecht University (Netherlands)
  • National Hellenic Research Foundation (Greece)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • University of Malaya (Malaysia)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • BMC Microbiol.2019, 19(1):78
  • Molecules.2018, 23(11):E2837
  • Mol Med Rep.2023 Oct;28(4):193.
  • J Nat Prod.2022, 85(5):1351-1362.
  • Phytomedicine.2022, 102:154183.
  • Chem Res Toxicol. 2022, acs.chemrestox.2c00049.
  • PLoS One.2022, 17(6):e0268505.
  • J Chromatogr A.2022, 1685:463640.
  • Int J Mol Sci.2021, 22(19):10405.
  • Plant Physiol Biochem.2019, 144:355-364
  • Molecules.2019, 24(11):E2102
  • Agronomy2020, 10(10),1489
  • Front Plant Sci.2022, 13:982771.
  • Journal of Functional Foods2021, 84:104581
  • Sci Rep.2021, 11(1):11936.
  • Agronomy2022, 12(10), 2426.
  • Anticancer Res.2021, 41(3):1357-1364.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1124:323-330
  • Molecules.2019, 24(16):E2985
  • J Chromatogr B Analyt Technol Biomed Life Sci.2022, 1203:123307.
  • Molecules2022, 27(12):3903.
  • Korean J. Medicinal Crop Sci.2018, 26(2):148-156
  • RSC Adv.2018, 32621-32636
  • ...
  • 生物活性
    Description: Polygalacic acid may exert a significant neuroprotective effect on cognitive impairment, driven in part by the modulation of cholinergic activity and neuroinflammation. Polygalacic acid shows significant postingestive effects on Spodoptera littoralis larvae.
    Targets: AChR | Immunology & Inflammation related
    In vitro:
    J Nat Prod. 2010 Nov 29;73(11):1863-7.
    Antiproliferative effects of saponins from the roots of Platycodon grandiflorum on cultured human tumor cells.[Pubmed: 20939516]

    METHODS AND RESULTS:
    Three new triterpenoid saponins, platyconic acid B lactone (1), deapio-platyconic acid B lactone (2), and deapio-platycodin D(2) (3), together with 17 known triterpenoid saponins, were isolated from a root extract of Platycodon grandiflorum. The structures of 1-3 were determined on the basis of spectroscopic data interpretation and chemical transformation.
    CONCLUSIONS:
    Saponins with a platycodigenin or polygalacic acid unit as a sapogenin demonstrated significant inhibitory effects on the proliferation of a small panel of cultured human tumor cells.
    Phytochemistry. 2011 Jun;72(8):743-51.
    Bioactive saponins from Microsechium helleri and Sicyos bulbosus.[Pubmed: 21439597 ]
    Eleven oleanane-type saponins (1-11) have been isolated from Microsechium helleri and Sicyos bulbosus roots and were evaluated for their antifeedant, nematicidal and phytotoxic activities.
    METHODS AND RESULTS:
    Saponins {3-O-β-D-glucopyranosyl (1→3)-β-D-glucopyranosyl-2β,3β,16α,23-tetrahydroxyolean-12-en-28-oic acid 28-O-α-L-rhamnopyranosyl-(1→3)-β-D-xylopyranosyl-(1→4)-[β-D-xylopyranosyl-(1→3)]-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranoside} (1), and {3-O-β-D-glucopyranosyl-2β,3β,16α,23-tetrahydroxyolean-12-en-28-oic acid 28-O-α-L-rhamnopyranosyl-(1→3)-β-D-xylopyranosyl-(1→4)-[β-D-xylopyranosyl-(1→3)]-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranoside} (2) were also isolated from M. helleri roots together with the two known compounds 3 and 4. Seven known structurally related saponins (5-11) were isolated from S. bulbosus roots. The structures of these compounds were established as bayogenin and polygalacic glycosides using one- and two-dimensional NMR spectroscopy and mass spectrometry. Compounds 7, 10, bayogenin (12) and Polygalacic acid (13) showed significant (p<0.05) postingestive effects on Spodoptera littoralis larvae, compounds 5-11 and 12 showed variable nematicidal effects on Meloydogyne javanica and all tested saponins had variable phytotoxic effects on several plant species (Lycopersicum esculentum, Lolium perenne and Lactuca sativa).
    CONCLUSIONS:
    These are promising results in the search for natural pesticides from the Cucurbitaceae family.
    In vivo:
    Phytomedicine. 2016 Feb 15;23(2):149-55.
    Neuroprotective effects of polygalacic acid on scopolamine-induced memory deficits in mice.[Pubmed: 26926176 ]
    Polygala tenuifolia Willd is a Traditional Chinese Medicine used for the treatment of learning and memory deficits.
    METHODS AND RESULTS:
    Triterpenoid saponins, the main bioactive compounds of Polygala tenuifolia Willd, are easily hydrolyzed to Polygalacic acid (PA).Treatment with scopolamine significantly increased the escape latency time, decreased the number of crossings, and shortened the time spent in the target quadrant, while PA reversed these scopolamine-induced effects. PA significantly improved cholinergic system reactivity, as indicated by decreased acetylcholinesterase (AChE) activity, increased choline acetyltransferase (ChAT) activity, and elevated levels of acetylcholine (ACh) in the hippocampus and frontal cortex. PA also significantly ameliorated neuroinflammation and oxidative stress in mice.
    CONCLUSIONS:
    These results suggest that PA might exert a significant neuroprotective effect on cognitive impairment, driven in part by the modulation of cholinergic activity and neuroinflammation.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9813 mL 9.9067 mL 19.8134 mL 39.6267 mL 49.5334 mL
    5 mM 0.3963 mL 1.9813 mL 3.9627 mL 7.9253 mL 9.9067 mL
    10 mM 0.1981 mL 0.9907 mL 1.9813 mL 3.9627 mL 4.9533 mL
    50 mM 0.0396 mL 0.1981 mL 0.3963 mL 0.7925 mL 0.9907 mL
    100 mM 0.0198 mL 0.0991 mL 0.1981 mL 0.3963 mL 0.4953 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Eucalyptolic acid; Eucalyptolic acid CFN92275 189272-68-2 C40H56O7 = 648.9 5mg QQ客服:1413575084
    脱氢山楂酸; Camaldulenic acid CFN96017 71850-15-2 C30H46O4 = 470.7 5mg QQ客服:215959384
    阿江榄仁酸; Arjunic acid CFN98397 31298-06-3 C30H48O5 = 488.7 5mg QQ客服:215959384
    阿江榄仁酸; Arjunolic acid CFN98690 465-00-9 C30H48O5 = 488.7 5mg QQ客服:2159513211
    阿江榄仁素; Arjungenin CFN95039 58880-25-4 C30H48O6 = 504.7 20mg QQ客服:1457312923
    3-O-香豆酰阿江榄仁酸; 3-O-Coumaroylarjunolic acid CFN96829 171864-20-3 C39H54O7 = 634.85 5mg QQ客服:2056216494
    2,3-二羟基-12-齐墩果烯-28-酸; 2,3-Dihydroxy-12-oleanen-28-oic acid CFN98310 26563-68-8 C30H48O4 = 472.7 5mg QQ客服:1413575084
    2,3,23-三羟基-12-齐墩果烯-28-酸; 2,3,23-Trihydroxy-12-oleanen-28-oic acid CFN99041 102519-34-6 C30H48O5 = 488.7 5mg QQ客服:3257982914
    2alpha,3alpha,24-三羟基-12-烯-28-齐墩果酸; 2,3,24-Trihydroxyolean-12-en-28-oic acid CFN99628 150821-16-2 C30H48O5 = 488.7 5mg QQ客服:2056216494
    贝萼皂苷元; 贝萼甙元; Bayogenin CFN90314 6989-24-8 C30H48O5 = 488.70 20mg QQ客服:3257982914

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