| J Org Chem. 2004 Sep 17;69(19):6165-72. |
| Structural modifications of plumieride isolated from Plumeria bicolor and the effect of these modifications on in vitro anticancer activity.[Pubmed: 15357574] |
Plumieride was isolated as one of the major components from the biologically active methanolic extract of the bark of Plumeria bicolor (family Apocynaceae). For investigating the effect of substituents on cytotoxic activity it was modified into a series of compounds.
METHODS AND RESULTS:
Replacing the methyl ester functionality of Plumieride with alkyl amides of variable carbon units improved the cytotoxic activity, and a correlation between overall lipophilicity and cytotoxic activity was observed. In Plumieride, the glucose moiety was converted into a di- and trisaccharide by following the protection and deprotection approach, and the resulting compounds produced enhanced cytotoxicity. However, these compounds were found to be less effective than plumeiride containing a dodecyl (12 carbon units) amide group.
CONCLUSIONS:
Among all of the derivatives, the naturally occurring Plumieride showed the least cytotoxicity (50% cell kill = 49.5 microg/mL), and the dodecyl amide analogue of Plumieridepentaacetate produced the best efficacy (50% cell kill = 11.8 microg/mL). The di- and trisaccharide analogues were found to be slightly less effective than the dodecyl derivative (50% cell kill = 15-17 microg/mL). The in vitro cytotoxicity of the Plumieride analogues was determined in radiation-induced fibrosarcoma (RIF) tumor cells. |
| Phytother Res. 2002 Jun;16(4):393-4. |
| Plumieride from Allamanda cathartica as an antidermatophytic agent.[Pubmed: 12112301 ] |
METHODS AND RESULTS:
Plumieride has been isolated as an active principle of the leaves of Allamanda cathartica. It showed strong fungitoxicity against some dermatophytes causing dermatomycosis to animals and human beings. It exhibited a noncytotoxic nature against a P(388) mouse leukaemia cell line. |
| Phytochemistry, 1979, 18(8):1399-400. |
| Plant growth inhibiting properties of plumieride from Plumeria obtusifolia.[Reference: WebLink] |
METHODS AND RESULTS:
Plant growth inhibiting properties of plumieride from Plumeria obtusifolia. |
| J&k State Science Congress, University of Jammu, Jammu. 2005. |
| Immunomodulatory activity of Plumieride, an iridoid glucoside from Plumieria acutifolia leaves.[Reference: WebLink] |
METHODS AND RESULTS:
Immunomodulatory activity of Plumieride, an iridoid glucoside from Plumieria acutifolia leaves. |
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