麻醉椒碱

Pipermethystine

	产品编号	CFN70441
	CAS编号	71627-22-0
	分子式 = 分子量	C₁₆H₁₇NO₄ = 287.3
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Alkaloids
	植物来源	The roots of Piper methysticum
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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麻醉椒碱	CFN70441	71627-22-0	1mg	QQ客服：215959384
麻醉椒碱	CFN70441	71627-22-0	5mg	QQ客服：215959384
麻醉椒碱	CFN70441	71627-22-0	10mg	QQ客服：215959384
麻醉椒碱	CFN70441	71627-22-0	20mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of South Australia (Australia)

Mahidol University (Thailand)

Technical University of Denmark (Denmark)

Colorado State University (USA)

Tohoku University (Japan)

Universidad de La Salle (Mexico)

University of Lodz (Poland)

Lodz University of Technology (Poland)

Max Rubner-Institut (MRI) (Germany)

Universite Libre de Bruxelles (Belgium)

Universidad Miguel Hernández (Spain)

University of Vigo (Spain)

The Vancouver Prostate Centre (VPC) (Canada)

University of Malaya (Malaysia)

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Description:

Pipermethystine induces mitochondrial toxicity in human hepatoma cells, it is capable of causing cell death, probably in part by disrupting mitochondrial function, thus, it may contribute to rare but severe hepatotoxic reactions to kava.

Targets:

ATP | CYP2E1

In vitro:

Toxicological Sciences,2004,79(1):106–111.

In Vitro Toxicity of Kava Alkaloid, Pipermethystine, in HepG2 Cells Compared to Kavalactones.[Reference: WebLink]

Kava herbal supplements have been recently associated with acute hepatotoxicity, leading to the ban of kava products in approximately a dozen countries around the world. It is suspected that some alkaloids from aerial kava may have contributed to the problem. Traditionally, Pacific Islanders use primarily the underground parts of the shrub to prepare the kava beverage. However, some kava herbal supplements may contain ingredients from aerial stem peelings.
METHODS AND RESULTS:
The aim of this study was to test the in vitro effects of a major kava alkaloid, pipermethystine (PM), found mostly in leaves and stem peelings, and kavalactones such as 7,8-dihydromethysticin (DHM) and desmethoxyyangonin (DMY), which are abundant in the roots. Exposure of human hepatoma cells, HepG2, to 100 μM PM caused 90% loss in cell viability within 24 h, while 50 μM caused 65% cell death. Similar concentrations of kavalactones did not affect cell viability for up to 8 days of treatment.
CONCLUSIONS:
Mechanistic studies indicate that, in contrast to kavalactones, PM significantly decreased cellular ATP levels, mitochondrial membrane potential, and induced apoptosis as measured by the release of caspase-3 after 24 h of treatment. These observations suggest that PM, rather than kavalactones, is capable of causing cell death, probably in part by disrupting mitochondrial function. Thus, PM may contribute to rare but severe hepatotoxic reactions to kava.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Hyperxanthone E; Hyperxanthone E	CFN91900	819860-76-9	C₁₈H₁₆O₆ = 328.32	5mg	QQ客服：1413575084
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拟人参皂苷F11; Pseudoginsenoside F11	CFN99963	69884-00-0	C₄₂H₇₂O₁₄ = 801.01	20mg	QQ客服：1457312923
甘松香酮 A; Kanshone A	CFN96977	115356-18-8	C₁₅H₂₂O₂ = 234.33	5mg	QQ客服：1413575084

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.4807 mL	17.4034 mL	34.8068 mL	69.6136 mL	87.0171 mL
5 mM	0.6961 mL	3.4807 mL	6.9614 mL	13.9227 mL	17.4034 mL
10 mM	0.3481 mL	1.7403 mL	3.4807 mL	6.9614 mL	8.7017 mL
50 mM	0.0696 mL	0.3481 mL	0.6961 mL	1.3923 mL	1.7403 mL
100 mM	0.0348 mL	0.174 mL	0.3481 mL	0.6961 mL	0.8702 mL