Kaempferol-3-O-α-L-rhamnopyranosyl-(1->6)-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside

Kaempferol-3-O-alpha-L-rhamnopyranosyl-(1->6)-beta-D-glucopyranosyl-(1->2)-beta-D-glucopyranoside

	产品编号	CFN91162
	CAS编号	476617-49-9
	分子式 = 分子量	C₃₃H₄₀O₂₀ = 756.7
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Flavonoids
	植物来源	The roots of Helicia erratica Hook. f.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
Kaempferol-3-O-α-L-rhamnopyranosyl-(1->6)-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside	CFN91162	476617-49-9	1mg	QQ客服：2159513211
Kaempferol-3-O-α-L-rhamnopyranosyl-(1->6)-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside	CFN91162	476617-49-9	5mg	QQ客服：2159513211
Kaempferol-3-O-α-L-rhamnopyranosyl-(1->6)-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside	CFN91162	476617-49-9	10mg	QQ客服：2159513211
Kaempferol-3-O-α-L-rhamnopyranosyl-(1->6)-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside	CFN91162	476617-49-9	20mg	QQ客服：2159513211

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Description:

Kaempferol-3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside shows antioxidant activity.

In vivo:

PLoS One. 2014 Jun 3;9(6):e98559.

Isolation of antiosteoporotic compounds from seeds of Sophora japonica.[Pubmed: 24892557 ]

Chemical investigation of Sophora japonica seeds resulted in the isolation of seven metabolites identified as: genistin (1), sophoricoside (2), sophorabioside (3), sophoraflavonoloside (4), genistein 7,4'-di-O-β-D-glucopyransoide (5), Kaempferol-3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside (6) and rutin (7). Compounds 1, 2 and 5 showed significant estrogenic proliferative effect in MCF-7 cell in sub-cytotoxic concentration range. Compounds 1 and 2 showed minimal cell membrane damaging effect using LDH leakage assay. Accordingly, compound 2 (sophoricoside, (SPH)) was selected for further in-vivo studies as a potential anti-osteoporosis agent. The anti-osteoporotic effect of SPH was assessed in ovarectomized (OVX) rats after oral administration (15 mg/kg and 30 mg/kg) for 45 days compared to estradiol (10 µg/kg) as a positive control. Only in a dose of 30 mg/kg, SPH regained the original mechanical bone hardness compared to normal non-osteoporotic group. However, SPH (15 mg/kg) significantly increased the level of alkaline phosphatase (ALP) to normal level. Treatment with SPH (30 mg/kg) increased the level of ALP to be higher than normal group. SPH (15 mg/kg) did not significantly increase the serum level of osteocalcin (OC) compared to OVX group. On the other hand, treatment with SPH (30 mg/kg) significantly increased the level of OC to 78% higher than normal non-ovarectomized animals group. In addition, SPH (15 mg/kg) decreased the bone resorption marker, acid phosphatase (ACP) to normal level and SPH (30 mg/kg) further diminished the level of serum ACP.
CONCLUSIONS:
Histopathologically, sophoricoside ameliorated the ovarectomy induced osteoporosis in a dose dependent manner. The drug showed thicker bony trabeculae, more osteoid, and more osteoblastic rimming compared to OVX group.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
山奈酚-3-O-芸香糖苷; Nicotiflorin	CFN99830	17650-84-9	C₂₇H₃₀O₁₅ = 594.5	20mg	QQ客服：2159513211
6-甲氧基山柰酚-3-O-芸香糖苷; 6-Methoxykaempferol 3-O-rutinoside	CFN90233	403861-33-6	C₂₈H₃₂O₁₆ = 624.6	5mg	QQ客服：3257982914
山奈酚 3-龙胆二糖苷; Kaempferol 3-gentiobioside	CFN92384	22149-35-5	C₂₇H₃₀O₁₆ = 610.5	20mg	QQ客服：2159513211
山奈酚-3-O-葡萄糖鼠李糖苷; Ternatumoside II	CFN95366	1473419-87-2	C₂₇H₃₀O₁₅ = 594.5	5mg	QQ客服：2056216494
豆腐果新苷A; Helicianeoide A	CFN90342	496066-82-1	C₃₂H₃₈O₁₉ = 726.63	5mg	QQ客服：2159513211
Kaempferol-3-O-α-L-rhamnopyranosyl-(1->6)-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside; Kaempferol-3-O-alpha-L-rhamnopyranosyl-(1->6)-beta-D-glucopyranosyl-(1->2)-beta-D-glucopyranoside	CFN91162	476617-49-9	C₃₃H₄₀O₂₀ = 756.7	10mg	QQ客服：3257982914
山茶甙B; Camelliaside B	CFN93560	131573-90-5	C₃₂H₃₈O₁₉ = 726.6	10mg	QQ客服：3257982914
毛里求斯排草素; Mauritianin	CFN90819	109008-28-8	C₃₃H₄₀O₁₉ = 740.7	10mg	QQ客服：1413575084
山茶甙A; Camelliaside A	CFN93559	135095-52-2	C₃₃H₄₀O₂₀ = 756.66	20mg	QQ客服：2056216494
Plantanone B; Plantanone B	CFN91161	55780-30-8	C₃₃H₄₀O₂₀ = 756.7	5mg	QQ客服：2159513211

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.3215 mL	6.6076 mL	13.2153 mL	26.4306 mL	33.0382 mL
5 mM	0.2643 mL	1.3215 mL	2.6431 mL	5.2861 mL	6.6076 mL
10 mM	0.1322 mL	0.6608 mL	1.3215 mL	2.6431 mL	3.3038 mL
50 mM	0.0264 mL	0.1322 mL	0.2643 mL	0.5286 mL	0.6608 mL
100 mM	0.0132 mL	0.0661 mL	0.1322 mL	0.2643 mL	0.3304 mL

Kaempferol-3-O-α-L-rhamnopyranosyl-(1->6)-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside

Kaempferol-3-O-alpha-L-rhamnopyranosyl-(1->6)-beta-D-glucopyranosyl-(1->2)-beta-D-glucopyranoside

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