苦玄参苷IA

Picfeltarraenin IA

	产品编号	CFN99942
	CAS编号	97230-47-2
	分子式 = 分子量	C₄₁H₆₂O₁₃ = 762.92
	产品纯度	>=98%
	物理属性	White powder
	化合物类型	Triterpenoids
	植物来源	The herbs of Picria felterrae Lour.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
苦玄参苷IA	CFN99942	97230-47-2	10mg	QQ客服：215959384
苦玄参苷IA	CFN99942	97230-47-2	20mg	QQ客服：215959384
苦玄参苷IA	CFN99942	97230-47-2	50mg	QQ客服：215959384
苦玄参苷IA	CFN99942	97230-47-2	100mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Sanford Burnham Medical Research Institute (USA)

Siksha O Anusandhan University (India)

University of Toronto (Canada)

University of Fribourg (Switzerland)

Subang Jaya Medical Centre (Malaysia)

Universidade Federal de Santa Catarina (Brazil)

Aveiro University (Portugal)

Monash University Sunway Campus (Malaysia)

Worcester Polytechnic Institute (USA)

Vin?a Institute of Nuclear Sciences (Serbia)

Mendel University in Brno (Czech Republic)

Chinese University of Hong Kong (China)

Kamphaengphet Rajabhat University (Thailand)

Universidad de Antioquia (Colombia)

More...

Description:

Picfeltarraenin IA has anti-inflammatory activity, it is a strong AChE inhibitior, and an potential PI3K and epidermal growth factor receptor (EGFR ) inhibitor. It acts as an inhibitor on both the classical and alternative pathways of the complement system.

Targets:

IL Receptor | PGE | NF-kB | COX | p65 | EGFR | PI3K | Akt

In vitro:

Oncol Lett. 2016 Feb;11(2):1195-1200.

Picfeltarraenin IA inhibits lipopolysaccharide-induced inflammatory cytokine production by the nuclear factor-κB pathway in human pulmonary epithelial A549 cells.[Pubmed: 26893718 ]

The present study aimed to investigate the effect of Picfeltarraenin IA (IA) on respiratory inflammation by analyzing its effect on interleukin (IL)-8 and prostaglandin E2 (PGE2) production. The expression of cyclooxygenase 2 (COX2) in human pulmonary adenocarcinoma epithelial A549 cells in culture was also examined.
METHODS AND RESULTS:
Human pulmonary epithelial A549 cells and the human monocytic leukemia THP-1 cell line were used in the current study. Cell viability was measured using a methylthiazol tetrazolium assay. The production of IL-8 and PGE2 was investigated using an enzyme-linked immunosorbent assay. The expression of COX2 and nuclear factor-κB (NF-κB)-p65 was examined using western blot analysis. Treatment with lipopolysaccharide (LPS; 10 μg/ml) resulted in the increased production of IL-8 and PGE2, and the increased expression of COX2 in the A549 cells. Furthermore, IA (0.1-10 μmol/l) significantly inhibited PGE2 production and COX2 expression in cells with LPS-induced IL-8, in a concentration-dependent manner. The results suggested that IA downregulates LPS-induced COX2 expression, and inhibits IL-8 and PGE2 production in pulmonary epithelial cells. Additionally, IA was observed to suppress the expression of COX2 in THP-1 cells, and also to regulate the expression of COX2 via the NF-κB pathway in the A549 cells, but not in the THP-1 cells.
CONCLUSIONS:
These results indicate that IA regulates LPS-induced cytokine release in A549 cells via the NF-κB pathway.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
苦玄参苷IV; Picfeltarraenin IV	CFN90719	184288-35-5	C₄₇H₇₂O₁₈ = 925.06	5mg	QQ客服：3257982914
苦玄参苷X; Picfeltarraenin X	CFN90730	1391826-61-1	C₃₆H₅₄O₁₁ = 662.81	5mg	QQ客服：1413575084
16,23-氧化泽泻醇B; 16,23-Oxidoalisol B	CFN95650	169326-06-1	C₃₀H₄₆O₄ = 470.7	5mg	QQ客服：2159513211
泽泻醇F; Alisol F	CFN92402	155521-45-2	C₃₀H₄₈O₅ = 488.7	10mg	QQ客服：215959384
25-甲基泽泻醇F; 25-Methoxyalisol F	CFN95657	2221029-53-2	C₃₁H₅₀O₅ = 502.7	5mg	QQ客服：215959384
24-去乙酰泽泻醇O; 24-Deacetylalisol O	CFN92407	1067510-31-9	C₃₀H₄₆O₄ = 470.7	5mg	QQ客服：1457312923
泽泻醇O; Alisol O	CFN92404	928148-51-0	C₃₂H₄₈O₅ = 512.7	5mg	QQ客服：2159513211
16-氧代泽泻醇A; 16-Oxoalisol A	CFN92547	124515-98-6	C₃₀H₄₈O₆ = 504.7	5mg	QQ客服：1413575084
泽泻醇C; Alisol C	CFN92545	30489-27-1	C₃₀H₄₆O₅ = 486.7	5mg	QQ客服：1457312923
泽泻醇 C-23-醋酸酯; Alisol C monoacetate	CFN90199	26575-93-9	C₃₂H₄₈O₆ = 528.73	20mg	QQ客服：2056216494

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.3108 mL	6.5538 mL	13.1075 mL	26.2151 mL	32.7688 mL
5 mM	0.2622 mL	1.3108 mL	2.6215 mL	5.243 mL	6.5538 mL
10 mM	0.1311 mL	0.6554 mL	1.3108 mL	2.6215 mL	3.2769 mL
50 mM	0.0262 mL	0.1311 mL	0.2622 mL	0.5243 mL	0.6554 mL
100 mM	0.0131 mL	0.0655 mL	0.1311 mL	0.2622 mL	0.3277 mL