氧化芍药苷

Oxypaeoniflorin

	产品编号	CFN99589
	CAS编号	39011-91-1
	分子式 = 分子量	C₂₃H₂₈O₁₂ = 496.46
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Monoterpenoids
	植物来源	The roots of Paeonia lactiflora Pall.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
氧化芍药苷	CFN99589	39011-91-1	10mg	QQ客服：2159513211
氧化芍药苷	CFN99589	39011-91-1	20mg	QQ客服：2159513211
氧化芍药苷	CFN99589	39011-91-1	50mg	QQ客服：2159513211
氧化芍药苷	CFN99589	39011-91-1	100mg	QQ客服：2159513211

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Stirling (United Kingdom)

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University of Illinois at Chicago (USA)

University of Ioannina (Greece)

Universidad Veracuzana (Mexico)

Instytut Nawozów Sztucznych w Pu?awach (Poland)

Korea Food Research Institute(KFRI) (Korea)

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Description:

Oxypaeoniflorin in rat plasma and was successfully applied to pharmacokinetic study.

In vitro:

Acta Biochim Pol . 2020 Jun 18;67(2):239-245.

Oxypaeoniflorin improves myocardial ischemia/reperfusion injury by activating the Sirt1/Foxo1 signaling pathway[Pubmed: 32550708]

Abstract Myocardial ischemia/reperfusion (MI/R) injury is a leading cause of damage to cardiac tissues and is associated with high mortality and disability rates worldwide. Oxypaeoniflorin (OPA) has been found to be the main constituent of Paeonia veitchii Lynch. This study was conducted to explore the effect of OPA on MI/R injury and its potential mechanism. An in vivo MI/R injury model was established by transient coronary ligation in BALB/c mice, and an in vitro hypoxia/reoxygenation (H/R) injury model was established with rat cardiomyocyte H9c2 cells. Echocardiographic assessments demonstrated that OPA significantly reduced disruption of cardiac function and improved the indicators of ejection fraction (EF) and fractional shortening (FS). The enzyme-linked immunosorbent assay (ELISA) results suggested that OPA significantly reduced the release of myocardial infarction-related factors, such as the creatine kinase (CK-MB), cardiac troponin I (cTnI) and cardiac troponin T (cTnT). Additionally, hematoxylin-eosin (HandE) staining demonstrated that OPA markedly inhibited the myocardial apoptosis and necrosis caused by MI/R. Consistently, the results obtained from the cell counting kit-8 (CCK-8) and flow cytometry assays revealed that OPA obviously reversed the H/R-induced decrease in cell activity and increase in apoptosis of H9c2 cells. Furthermore, western blot assays indicated that OPA inhibited apoptosis by activating the Sirt1 (silent information regulator factor 2 related enzyme 1)/Foxo1(forkhead transcription factor FKHR) signaling pathway in myocardial tissues and H9c2 cells. Collectively, these novel findings are the first to provide strong evidence that OPA attenuates MI/R injury by activating the Sirt1 (silent information regulator factor 2 related enzyme 1)/Foxo1(forkhead transcription factor FKHR) signaling-mediated anti-apoptotic pathway.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
芍药苷; Paeoniflorin	CFN99544	23180-57-6	C₂₃H₂₈O₁₁ = 480.45	20mg	QQ客服：2056216494
氧化芍药苷; Oxypaeoniflorin	CFN99589	39011-91-1	C₂₃H₂₈O₁₂ = 496.46	20mg	QQ客服：215959384
2'-O-苯甲酰基芍药甙; 2'-O-Benzoylpaeoniflorin	CFN89529	1456598-64-3	C₃₀H₃₂O₁₂ = 584.56	5mg	QQ客服：1457312923
苯甲酰芍药苷; Benzoylpaeoniflorin	CFN99536	38642-49-8	C₃₀H₃₂O₁₂ = 584.57	20mg	QQ客服：1413575084
苯甲酰氧化芍药苷; Benzoyloxypeoniflorin	CFN90662	72896-40-3	C₃₀H₃₂O₁₃ = 600.57	20mg	QQ客服：3257982914
牡丹皮苷C; Mudanpioside C	CFN90661	172760-03-1	C₃₀H₃₂O₁₃ = 600.57	20mg	QQ客服：215959384
没食子酰芍药苷; Galloylpaeoniflorin	CFN90831	122965-41-7	C₃₀H₃₂O₁₅ = 632.6	10mg	QQ客服：2056216494
芍药苷元酮; Paeoniflorigenone	CFN96022	80454-42-8	C₁₇H₁₈O₆ = 318.3	5mg	QQ客服：215959384
芍药内苷B; Paeonilactone B	CFN96055	98751-78-1	C₁₀H₁₂O₄ = 196.2	5mg	QQ客服：1457312923
芍药内苷C; Paeonilactone C	CFN96056	98751-77-0	C₁₇H₁₈O₆ = 318.3	5mg	QQ客服：215959384

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.0143 mL	10.0713 mL	20.1426 mL	40.2852 mL	50.3565 mL
5 mM	0.4029 mL	2.0143 mL	4.0285 mL	8.057 mL	10.0713 mL
10 mM	0.2014 mL	1.0071 mL	2.0143 mL	4.0285 mL	5.0357 mL
50 mM	0.0403 mL	0.2014 mL	0.4029 mL	0.8057 mL	1.0071 mL
100 mM	0.0201 mL	0.1007 mL	0.2014 mL	0.4029 mL	0.5036 mL