氧化芍药苷
Oxypaeoniflorin
|
|
产品编号 |
CFN99589 |
| CAS编号 |
39011-91-1 |
| 分子式 = 分子量 |
C23H28O12 = 496.46 |
| 产品纯度 |
>=98% |
| 物理属性 |
Powder |
| 化合物类型 |
Monoterpenoids |
| 植物来源 |
The roots of Paeonia lactiflora Pall. |
| ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 氧化芍药苷 |
CFN99589 |
39011-91-1 |
10mg |
QQ客服：1413575084 |
| 氧化芍药苷 |
CFN99589 |
39011-91-1 |
20mg |
QQ客服：1413575084 |
| 氧化芍药苷 |
CFN99589 |
39011-91-1 |
50mg |
QQ客服：1413575084 |
| 氧化芍药苷 |
CFN99589 |
39011-91-1 |
100mg |
QQ客服：1413575084 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
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University of Helsinki (Finland)
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Semmelweis Unicersity (Hungary)
Research Unit Molecular Epigenetics (MEG) (Germany)
Centralised Purchases Unit (CPU), B.I.T.S (India)
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Shanghai University of TCM (China)
Korea Intitute of Science and Technology (KIST) (Korea)
Heidelberg University (Germany)
Shanghai Institute of Organic Chemistry (China)
Utrecht University (Netherlands)
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国外学术期刊发表的引用ChemFaces产品的部分文献
| Description: |
Oxypaeoniflorin in rat plasma and was successfully applied to pharmacokinetic study.
|
| In vitro: |
| Acta Biochim Pol . 2020 Jun 18;67(2):239-245. | | Oxypaeoniflorin improves myocardial ischemia/reperfusion injury by activating the Sirt1/Foxo1 signaling pathway[Pubmed: 32550708] | | Abstract
Myocardial ischemia/reperfusion (MI/R) injury is a leading cause of damage to cardiac tissues and is associated with high mortality and disability rates worldwide. Oxypaeoniflorin (OPA) has been found to be the main constituent of Paeonia veitchii Lynch. This study was conducted to explore the effect of OPA on MI/R injury and its potential mechanism. An in vivo MI/R injury model was established by transient coronary ligation in BALB/c mice, and an in vitro hypoxia/reoxygenation (H/R) injury model was established with rat cardiomyocyte H9c2 cells. Echocardiographic assessments demonstrated that OPA significantly reduced disruption of cardiac function and improved the indicators of ejection fraction (EF) and fractional shortening (FS). The enzyme-linked immunosorbent assay (ELISA) results suggested that OPA significantly reduced the release of myocardial infarction-related factors, such as the creatine kinase (CK-MB), cardiac troponin I (cTnI) and cardiac troponin T (cTnT). Additionally, hematoxylin-eosin (HandE) staining demonstrated that OPA markedly inhibited the myocardial apoptosis and necrosis caused by MI/R. Consistently, the results obtained from the cell counting kit-8 (CCK-8) and flow cytometry assays revealed that OPA obviously reversed the H/R-induced decrease in cell activity and increase in apoptosis of H9c2 cells. Furthermore, western blot assays indicated that OPA inhibited apoptosis by activating the Sirt1 (silent information regulator factor 2 related enzyme 1)/Foxo1(forkhead transcription factor FKHR) signaling pathway in myocardial tissues and H9c2 cells. Collectively, these novel findings are the first to provide strong evidence that OPA attenuates MI/R injury by activating the Sirt1 (silent information regulator factor 2 related enzyme 1)/Foxo1(forkhead transcription factor FKHR) signaling-mediated anti-apoptotic pathway. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
2.0143 mL |
10.0713 mL |
20.1426 mL |
40.2852 mL |
50.3565 mL |
| 5 mM |
0.4029 mL |
2.0143 mL |
4.0285 mL |
8.057 mL |
10.0713 mL |
| 10 mM |
0.2014 mL |
1.0071 mL |
2.0143 mL |
4.0285 mL |
5.0357 mL |
| 50 mM |
0.0403 mL |
0.2014 mL |
0.4029 mL |
0.8057 mL |
1.0071 mL |
| 100 mM |
0.0201 mL |
0.1007 mL |
0.2014 mL |
0.4029 mL |
0.5036 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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