Oteromycin

	产品编号	CFN00129
	CAS编号	170591-45-4
	分子式 = 分子量	C₃₂H₄₁NO₃ = 487.68
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Alkaloids
	植物来源	From fungi MF5810 and MF5811.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
Oteromycin	CFN00129	170591-45-4	1mg	QQ客服：1413575084
Oteromycin	CFN00129	170591-45-4	5mg	QQ客服：1413575084
Oteromycin	CFN00129	170591-45-4	10mg	QQ客服：1413575084
Oteromycin	CFN00129	170591-45-4	20mg	QQ客服：1413575084

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Malaya (Malaysia)

Warszawski Uniwersytet Medyczny (Poland)

Anna University (India)

Lodz University of Technology (Poland)

Univerzita Karlova v Praze (Czech Republic)

Monash University (Australia)

Monash University Malaysia (Malaysia)

The Institute of Cancer Research (United Kingdom)

University of East Anglia (United Kingdom)

Regional Crop Research Institute (Korea)

University of Illinois at Chicago (USA)

University of Zurich (Switzerland)

Agricultural Research Organization (ARO) (Israel)

Research Unit Molecular Epigenetics (MEG) (Germany)

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Description:

Oteromycin is a inhibitor of HIV-1 integrase.

Targets:

HIV

In vitro:

Antivir Chem Chemother. 1999 Mar;10(2):63-70.

Isolation and characterization of novel human immunodeficiency virus integrase inhibitors from fungal metabolites.[Pubmed: 10335400]

We have identified a series of novel inhibitors of human immunodeficiency virus type 1 (HIV-1) integrase by randomly screening natural product extracts using an in vitro biochemical assay designed to identify inhibitors of integrase-catalysed strand transfer.
METHODS AND RESULTS:
Equisetin recovered from the fungus Fusarium heterosporum and a novel enantiomeric homologue of equisetin from Phoma sp. were isolated as inhibitors of HIV-1 integrase in vitro. Two additional analogues, a novel decalin derivative, integric acid, and oteromycin were also discovered to be inhibitors of integrase. Equisetin and related compounds inhibit 3' end-processing and strand transfer as well as disintegration catalysed by either the full-length enzyme or the truncated integrase core domain (amino acids 50-212). These compounds also inhibit strand transfer reactions catalysed by stable complexes assembled in vitro and integration reactions catalysed by pre-integration complexes isolated from HIV-1-infected cells. The compounds described in this report are structurally novel and mechanistically distinct from many previously described inhibitors of HIV-1 integrase.
CONCLUSIONS:
These results demonstrate the utility of using an appropriately configured assay to identify compounds that are effective post-assembly and the potential of isolating novel integrase inhibitors from complex natural product extracts.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
抗菌素 2158; Antibiotic 2158	CFN00105	182320-34-9	C₃₃H₄₅NO₄ = 519.72	5mg	QQ客服：2159513211
抗菌素 AB 4015B; Antibiotic AB 4015B	CFN00106	162857-79-6	C₂₆H₃₉NO₃ = 413.6	5mg	QQ客服：2056216494
抗菌素 AB 4063B; Antibiotic AB 4063B	CFN00107	160041-33-8	C₂₆H₃₉NO₃ = 413.6	5mg	QQ客服：2159513211
抗菌素 PF 1052; Antibiotic PF 1052	CFN00108	147317-15-5	C₂₆H₃₉NO₄ = 429.60	5mg	QQ客服：2056216494
Delaminomycin A; Delaminomycin A	CFN00113	149779-38-4	C₂₉H₄₃NO₆ = 501.66	5mg	QQ客服：2056216494
伊快霉素; Equisetin	CFN00115	57749-43-6	C₂₂H₃₁NO₄ = 373.49	5mg	QQ客服：3257982914
Oteromycin; Oteromycin	CFN00129	170591-45-4	C₃₂H₄₁NO₃ = 487.68	5mg	QQ客服：2159513211
抗菌素 ZG 1494alpha; Antibiotic ZG 1494alpha	CFN00130	182320-33-8	C₃₂H₄₃NO₄ = 505.70	5mg	QQ客服：2159513211
Vermisporin; Vermisporin	CFN00143	122301-98-8	C₂₅H₃₇NO₄ = 415.57	5mg	QQ客服：2056216494
Zopfiellamide A; Zopfiellamide A	CFN00145	478945-64-1	C₂₅H₃₅NO₆ = 445.55	5mg	QQ客服：1457312923

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.0505 mL	10.2526 mL	20.5052 mL	41.0105 mL	51.2631 mL
5 mM	0.4101 mL	2.0505 mL	4.101 mL	8.2021 mL	10.2526 mL
10 mM	0.2051 mL	1.0253 mL	2.0505 mL	4.101 mL	5.1263 mL
50 mM	0.041 mL	0.2051 mL	0.4101 mL	0.8202 mL	1.0253 mL
100 mM	0.0205 mL	0.1025 mL	0.2051 mL	0.4101 mL	0.5126 mL