木蝴蝶苷B

Oroxin B

	产品编号	CFN99713
	CAS编号	114482-86-9
	分子式 = 分子量	C₂₇H₃₀O₁₅ = 594.52
	产品纯度	>=98%
	物理属性	Yellow powder
	化合物类型	Flavonoids
	植物来源	The roots of Scutellaria baicalensis.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

提供自定义包装

产品名称	产品编号	CAS编号	包装	QQ客服
木蝴蝶苷B	CFN99713	114482-86-9	10mg	QQ客服：2159513211
木蝴蝶苷B	CFN99713	114482-86-9	20mg	QQ客服：2159513211
木蝴蝶苷B	CFN99713	114482-86-9	50mg	QQ客服：2159513211
木蝴蝶苷B	CFN99713	114482-86-9	100mg	QQ客服：2159513211

存储与注意事项

1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。

2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。通常，这些可用于长达两周。使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。

3. 需要更多关于溶解度，使用和处理的建议？请发送电子邮件至：service@chemfaces.com

订购流程

1. 在线订购

请联系我们QQ客服

2. 电话订购

请拨打电话：
027-84237683 或 027-84237783

3. 邮件或传真订购

发送电子邮件到: manager@chemfaces.com 或
发送传真到：027-84254680

提供订购信息

为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。

1. 产品编号（CAS No.或产品名称）

2. 发货地址

3. 联系方法 (联系人，电话）

4. 开票抬头 (如果需要发票的客户）

5. 发票地址（发货地址与发票地址不同）

发货时间

1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。

2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。

3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。

ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Description:

Oroxin B can selectively induce tumor-suppressive ER stress and concurrently inhibit tumor-adaptive ER stress in B-lymphoma cells for effective anti-lymphoma therapy.

Targets:

p38MAPK

In vitro:

PLoS One. 2013 Nov 27;8(11):e80197.

Molecular modeling reveals the novel inhibition mechanism and binding mode of three natural compounds to staphylococcal α-hemolysin.[Pubmed: 24312202 ]

METHODS AND RESULTS:
In this study, we found that three natural compounds, Oroxylin A 7-O-glucuronide (OLG), Oroxin A (ORA), and Oroxin B (ORB), when inhibiting the hemolytic activity of α-HL, could bind to the "stem" region of α-HL. This was completed using conventional Molecular Dynamics (MD) simulations. By interacting with the novel binding sites of α-HL, the ligands could form strong interactions with both sides of the binding cavity.
CONCLUSIONS:
The results of the principal component analysis (PCA) indicated that because of the inhibitors that bind to the "stem" region of α-HL, the conformational transition of α-HL from the monomer to the oligomer was restricted. This caused the inhibition of the hemolytic activity of α-HL.

In vivo:

Toxicol Appl Pharmacol. 2015 Oct 15;288(2):269-79.

Oroxin B selectively induces tumor-suppressive ER stress and concurrently inhibits tumor-adaptive ER stress in B-lymphoma cells for effective anti-lymphoma therapy.[Pubmed: 26253462 ]

Cancer cells have both tumor-adaptive and -suppressive endoplasmic reticulum (ER) stress machineries that determine cell fate. In malignant tumors including lymphoma, constant activation of tumor-adaptive ER stress and concurrent reduction of tumor-suppressive ER stress favors cancer cell proliferation and tumor growth. Current ER stress-based anti-tumor drugs typically activate both tumor-adaptive and -suppressive ER stresses, resulting in low anti-cancer efficacy; hence, selective induction of tumor-suppressive ER stress and inhibition of tumor-adaptive ER stress are new strategies for novel anti-cancer drug discovery. Thus far, specific tumor-suppressive ER stress therapeutics have remained absent in clinical settings.
METHODS AND RESULTS:
In this study, we explored unique tumor-suppressive ER stress agents from the traditional Chinese medicinal herb Oroxylum indicum, and found that a small molecule oroxin B selectively induced tumor-suppressive ER stress in malignant lymphoma cells, but not in normal cells, effectively inhibited lymphoma growth in vivo, and significantly prolonged overall survival of lymphoma-xenografted mice without obvious toxicity. Mechanistic studies have revealed that the expression of key tumor-adaptive ER-stress gene GRP78 was notably suppressed by oroxin B via down-regulation of up-stream key signaling protein ATF6, while tumor-suppressive ER stress master gene DDIT3 was strikingly activated through activating the MKK3-p38 signaling pathway, correcting the imbalance between tumor-suppressive DDIT3 and tumor-adaptive GRP78 in lymphoma.
CONCLUSIONS:
Together, selective induction of unique tumor-suppressive ER stress and concurrent inhibition of tumor-adaptive ER stress in malignant lymphoma are new and feasible approaches for novel anti-lymphoma drug discovery and anti-lymphoma therapy.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
黄芩素 7-O-beta-D-葡萄糖醛酸乙酯; Baicalein 7-O-beta-D-ethylglucuronide	CFN91993	675624-38-1	C₂₃H₂₂O₁₁ = 474.41	5mg	QQ客服：2056216494
黄芩素 6-O-葡萄糖苷; Baicalein 6-O-glucoside	CFN92361	28279-72-3	C₂₁H₂₀O₁₀ = 432.4	5mg	QQ客服：2056216494
木蝴蝶苷B; Oroxin B	CFN99713	114482-86-9	C₂₇H₃₀O₁₅ = 594.52	20mg	QQ客服：1457312923
千层纸素A-7-0-β-D-葡萄糖醛酸苷; Oroxylin A 7-O-beta-D-glucuronide	CFN90191	36948-76-2	C₂₂H₂₀O₁₁ = 460.39	20mg	QQ客服：215959384
千层纸素A-7-0-β-D-葡萄糖醛酸苷甲酯; Oroxylin A 7-O-beta-D-glucuronide methyl ester	CFN92282	82475-01-2	C₂₃H₂₂O₁₁ = 474.4	5mg	QQ客服：215959384
Glychionide A; Glychionide A	CFN92280	119152-50-0	C₂₁H₁₈O₁₁ = 446.4	5mg	QQ客服：3257982914
去甲汉黄芩素-8-O-葡萄糖醛酸苷; Norwogonin-8-O-glucuronide	CFN95423	118525-47-6	C₂₁H₁₈O₁₁ = 446.4	5mg	QQ客服：2159513211
汉黄芩苷; Wogonoside	CFN99710	51059-44-0	C₂₂H₂₀O₁₁ = 460.39	20mg	QQ客服：1457312923
穿心莲黄酮苷C; Andrographidine C	CFN97852	113963-39-6	C₂₃H₂₄O₁₀ = 460.44	5mg	QQ客服：215959384
5-Hydroxy-7,8-dimethoxy (2R)-flavanone-5-O-beta-D-glucopyranoside; 5-Hydroxy-7,8-dimethoxy (2R)-flavanone-5-O-beta-D-glucopyranoside	CFN95209	942626-74-6	C₂₃H₂₆O₁₀ = 462.5	10mg	QQ客服：2159513211

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.682 mL	8.4101 mL	16.8203 mL	33.6406 mL	42.0507 mL
5 mM	0.3364 mL	1.682 mL	3.3641 mL	6.7281 mL	8.4101 mL
10 mM	0.1682 mL	0.841 mL	1.682 mL	3.3641 mL	4.2051 mL
50 mM	0.0336 mL	0.1682 mL	0.3364 mL	0.6728 mL	0.841 mL
100 mM	0.0168 mL	0.0841 mL	0.1682 mL	0.3364 mL	0.4205 mL

木蝴蝶苷B

Oroxin B

信息支持

联系方式