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  • 商陆素; 3,5 ,3'-三羟基-7,4'-二甲氧基黄酮

    Ombuin

    商陆素; 3,5 ,3'-三羟基-7,4'-二甲氧基黄酮
    产品编号 CFN98876
    CAS编号 529-40-8
    分子式 = 分子量 C17H14O7 = 330.3
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The heartwoods of Caesalpinia sappan L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    商陆素; 3,5 ,3'-三羟基-7,4'-二甲氧基黄酮 CFN98876 529-40-8 1mg QQ客服:2056216494
    商陆素; 3,5 ,3'-三羟基-7,4'-二甲氧基黄酮 CFN98876 529-40-8 5mg QQ客服:2056216494
    商陆素; 3,5 ,3'-三羟基-7,4'-二甲氧基黄酮 CFN98876 529-40-8 10mg QQ客服:2056216494
    商陆素; 3,5 ,3'-三羟基-7,4'-二甲氧基黄酮 CFN98876 529-40-8 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Seoul National University (Korea)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • Max Rubner-Institut (MRI) (Germany)
  • University of Parma (Italy)
  • Texas A&M University (USA)
  • University of Auckland (New Zealand)
  • Lund University (Sweden)
  • University of Virginia (USA)
  • Washington State University (USA)
  • John Innes Centre (United Kingdom)
  • University of Sao Paulo (Brazil)
  • University of Toulouse (France)
  • University of Wisconsin-Madison (USA)
  • Melbourne University (Australia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2019, 24(10):E1930
  • International J of Green Pharmacy2019, 13(3)
  • Drug Invention Today2019, 12(6):1303-1306
  • Chem Res Toxicol.2023, 36(2):213-229.
  • J Nutr Biochem.2022, 107:109064.
  • Polytechnic University of Catalonia2017, 105826
  • J Insect Sci.2020, 20(5):18.
  • Molecules.2019, 24(10):E1926
  • Phytomedicine.2019, 58:152893
  • Int. J. Mol. Sci.2022, 23(14),7699;
  • Int J Mol Sci.2022, 23(11):6172.
  • Front Endocrinol (Lausanne).2020, 11:568436.
  • Vietnam Journal of Food Control.2022, 5(3):pp.488-497.
  • Sci Rep.2023, 13(1):7475.
  • Int J Mol Sci.2018, 19(9):E2528
  • J of Applied Biological Chem.2020, 63(2):147-152
  • J.the Korean Socie. Food Sci.&Nut.2023; 52(1):26-39.
  • Research on Crops.2017, 18(3):569
  • Auburn University2015, 1-58
  • Tissue Cell.2022, 78:101901.
  • Anesth Pain Med (Seoul).2020, 15(4):478-485.
  • Oxid Med Cell Longev.2022, 2022:9139338.
  • Biorxiv.2020, doi: 10.1101.
  • ...
  • 生物活性
    Description: Ombuin has anti-inflammary activity, it inhibits some macrophage functions involved in the inflammatory process. Ombuin significantly and dose dependently inhibits lipopolysaccharide (LPS) and interferon (IFN)-gamma induced nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12].
    Targets: NO | IFN-γ | IL Receptor | TNF-α
    In vitro:
    Phytother Res. 2008 Jul;22(7):957-62.
    Antiinflammatory activities of flavonoids and a triterpene caffeate isolated from Bauhinia variegata.[Pubmed: 18384188]
    In the continuing search for novel antiinflammatory agents, six flavonoids, namely kaempferol (1), ombuin (2), kaempferol 7,4'-dimethyl ether 3-O-beta-D-glucopyranoside (3), kaempferol 3-O-beta-D-glucopyranoside (4), isorhamnetin 3-O-beta-D-glucopyranoside (5) and hesperidin (6), together with one triterpene caffeate, 3beta-trans-(3,4-dihydroxycinnamoyloxy)olean-12-en-28-oic acid (7) were isolated from the non-woody aerial parts of Bauhinia variegata.
    METHODS AND RESULTS:
    Compounds 1-7 were evaluated as inhibitors of some macrophage functions involved in the inflammatory process. These seven compounds significantly and dose dependently inhibited lipopolysaccharide (LPS) and interferon (IFN)-gamma induced nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12]. The concentration causing a 50% inhibition (IC50) of NO, TNF-alpha and IL-12 production by compounds 1, 2 and 7 was approximately 30, 50 and 10 microM, respectively, while at 50, 200 and 40 microM compounds 3, 4, and 5, 6 showed 15-30% inhibition, respectively. On the other hand, compounds 3 and 7 showed no inhibitory effect, while compounds 1, 4-6 reduced by around 10-30% the synthesis of NO by macrophages, when inducible NO synthase was already expressed with LPS/IFN-gamma for 24 h.
    CONCLUSIONS:
    These experimental findings lend pharmacological support to the suggested folkloric uses of the plant B. variegata in the management of inflammatory conditions.
    Planta Med. 1998 Jun;64(5):464-6.
    Licochalcone A: an inducer of cell differentiation and cytotoxic agent from Pogostemon cablin.[Pubmed: 9690352]
    Licochalcone A (1), ombuin (2), and 5,7-dihydroxy-3',4'-dimethoxyflavanone (3) were isolated from the aerial parts of Pogostemon cablin by cytotoxicity-guided fractionation.
    METHODS AND RESULTS:
    Compound 1 showed in vitro cytotoxicity and Pl-PLC gamma 1 inhibition activity. Treatment of promyelocytic leukemia cells (HL-60) with compound 1 induced terminal differentiation with the generation of monocyte using nonspecific acid esterase assay.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0276 mL 15.1378 mL 30.2755 mL 60.551 mL 75.6888 mL
    5 mM 0.6055 mL 3.0276 mL 6.0551 mL 12.1102 mL 15.1378 mL
    10 mM 0.3028 mL 1.5138 mL 3.0276 mL 6.0551 mL 7.5689 mL
    50 mM 0.0606 mL 0.3028 mL 0.6055 mL 1.211 mL 1.5138 mL
    100 mM 0.0303 mL 0.1514 mL 0.3028 mL 0.6055 mL 0.7569 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    蔓荆子黄素; Vitexicarpin CFN98172 479-91-4 C19H18O8 = 374.34 20mg QQ客服:1413575084
    异鼠李素; Isorhamnetin CFN98735 480-19-3 C16H12O7 = 316.3 20mg QQ客服:1457312923
    槲皮素-3,3'-二甲醚; Quercetin 3,3'-dimethyl ether CFN89506 4382-17-6 C17H14O7 = 330.28 5mg QQ客服:2056216494
    槲皮素3,5,3'-三甲基醚; Quercetin 3,5,3'-trimethyl ether CFN91556 13459-09-1 C18H16O7 = 344.3 5mg QQ客服:2056216494
    甲基鼠李素; Rhamnazin CFN70409 552-54-5 C17H14O7 = 330.3 5mg QQ客服:215959384
    霍香黃酮醇; Pachypodol CFN98433 33708-72-4 C18H16O7 = 344.3 10mg QQ客服:1457312923
    柠檬黄素; Limocitrin CFN92385 489-33-8 C17H14O8 = 346.3 5mg QQ客服:215959384
    菠叶素; Spinacetin CFN95194 3153-83-1 C17H14O8 = 346.3 5mg QQ客服:2159513211
    棕鳞矢车菊黄酮素; Jaceidin CFN99032 10173-01-0 C18H16O8 = 360.3 5mg QQ客服:215959384
    三乙酸棕鳞矢车菊黄酮素酯; Jaceidin triacetate CFN99482 14397-69-4 C24H22O11 = 486.4 5mg QQ客服:215959384

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