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  • 羌活醇

    Notopterol

    羌活醇
    产品编号 CFN98563
    CAS编号 88206-46-6
    分子式 = 分子量 C21H22O5 = 354.40
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The roots of Notopterygium incisum.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    羌活醇 CFN98563 88206-46-6 10mg QQ客服:2056216494
    羌活醇 CFN98563 88206-46-6 20mg QQ客服:2056216494
    羌活醇 CFN98563 88206-46-6 50mg QQ客服:2056216494
    羌活醇 CFN98563 88206-46-6 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • Kamphaengphet Rajabhat University (Thailand)
  • FORTH-IMBB (Greece)
  • Medizinische Universit?t Wien (Austria)
  • Monash University Sunway Campus (Malaysia)
  • Mendel University in Brno (Czech Republic)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • University of Dicle (Turkey)
  • University of Toronto (Canada)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • Lodz University of Technology (Poland)
  • Deutsches Krebsforschungszentrum (Germany)
  • University of Pretoria (South Africa)
  • Kyung Hee University (Korea)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Foods.2021, 10(12):2929.
  • Free Radic Biol Med.2021, 166:104-115.
  • Food Science and Human Wellness2022, 11(4):965-974
  • J Pharmaceutical Research Int.2021, 33(41A):275-284.
  • Front Cell Dev Biol.2021, 9:764263.
  • European Journal of Integrative Medicine2018, 20:165-172
  • Phytother Res.2023, 37(10):4587-4606.
  • J Agric Food Chem.2017, 65(13):2670-2676
  • J Pharm Pharmacol.2022, rgac033.
  • Molecules.2019, 24(12):E2286
  • Universidade Estadual Paulista2017, 42785
  • Process Biochemistry2019, 85:106-115
  • Cell Death Dis.2019, 10(12):882
  • Kor. J. Pharmacogn.2016, 47(1):62-72
  • Cell Death Differ.2021, 1-8.
  • Food Sci Biotechnol.2023, 32(7):997-1003.
  • Institute of Food Science & Technology2021, 45(9).
  • Appl. Sci. 2021, 11(8),3437.
  • Nutr Cancer.2022, 1-13.
  • J AOAC Int.2021, 104(6):1634-1651.
  • Plant Methods.2017, 13:108
  • Molecules.2019, 24(22):E4022
  • Processes2021, 9(1), 153.
  • ...
  • 生物活性
    Description: Notopterol is a kind of furanocoumarin that possesses anti-inflammatory, analgesic, and anticancer activities, it shows significant antiproliferative activity against the HepG-2, MCF-7 and C6 cancer cell lines.
    Targets: Immunology & Inflammation related
    In vitro:
    Planta Med. 2010 Jan;76(1):82-5.
    Antiproliferative and apoptotic activities of linear furocoumarins from Notopterygium incisum on cancer cell lines.[Pubmed: 19653148]
    Bioassay-guided fractionation of the antiproliferative chloroform extract of the traditional Chinese medicine Qiang-Huo (Notopterygium incisum) led to the isolation of nine linear furocoumarins (1- 9).
    METHODS AND RESULTS:
    All the isolates were tested against two human cancer cell lines (HepG-2 and MCF-7) and a rat cancer cell line (C6) using the MTT assay method. Among them, notopol (1), notopterol (2), 5-[(2 E,5 Z)-7-hydroxy-3,7-dimethyl-2,5-octadienoxy]psoralene (3), and 5-[(2,5)-epoxy-3-hydroxy-3,7-dimethyl-6-octenoxy]psoralene (4) showed significant antiproliferative activity against the HepG-2 and C6 cancer cell lines, with IC(50) values of 7.7-24.8 microg/mL (5-FU: ca. 5 microg/mL). Compounds 1- 3 also showed moderate cytotoxicity against the MCF-7 cancer cell line, with IC(50) values of 39.4-61.3 microg/mL (5-FU: 17.3 microg/mL). The cell cycle-specific inhibition and apoptosis induced by compounds 1 and 2 were determined using flow cytometry.
    CONCLUSIONS:
    The structure-activity relationship (SAR) is briefly discussed herein. It was found that the presence of a free hydroxy at the lipophilic side chain linked to C-5 of the linear furocoumarins was essential for their in vitro antiproliferative activity.
    In vivo:
    Chem Pharm Bull (Tokyo). 1993 May;41(5):926-9.
    Analgesic component of Notopterygium incisum Ting.[Pubmed: 8339339]

    METHODS AND RESULTS:
    Notopterol was identified as the analgesic component of Notopterygium incisum TING by using the acetic acid-induced writhing method. Notopterol also indicated an anti-inflammatory activity by its inhibitory effect in the vascular permeability test. The intensive prolongation of pentobarbital-induced hypnosis was possibly caused by its inhibitory effect on the drug metabolism in liver. Pharmacological differences between the analgesic components of N. incisum, Aralia cordata and Angelica pubescens were also discussed.
    Drug Des Devel Ther . 2019 Jun 6;13:1927-1940.
    Notopterol-induced apoptosis and differentiation in human acute myeloid leukemia HL-60 cells[Pubmed: 31239643]
    Abstract Purpose: This study aims to observe the effects of notopterol on the apoptosis and differentiation of HL-60 cells and to explore the underlying molecular mechanisms. Methods: Cell viability was assessed using sulforhodamine B assay. Cell proliferation was determined by the trypan blue dye exclusion test. Colony-forming units were assayed in methylcellulose. Apoptosis assays were carried out by annexin V-fluorescein isothiocyanate(FITC)/propidium iodide (PI) double staining, Hoechst 33342 staining, mitochondrial membrane potential, and Western blot. Wright-Giemsa staining, nitroblue tetrazolium (NBT) reduction assay, CD11b and CD14 and Western blot were detected for induction of differentiation. In addition, cell-cycle phase distribution was analyzed by flow cytometry and Western blot. The combination therapy of notopterol and all-trans retinoic acid (ATRA) on HL-60 cells was examined. Results: Notopterol obviously inhibited the growth of HL-60 cells with an IC50 value of 40.32 μM and remarkably reduced the number of colonies by 10, 20, and 40 μM. In addtion, notopterol induced the percentage of apoptotic HL-60 cells, reduced the mitochondrial membrane potential, decreased the protein expresstion of Bcl-2 and Mcl-1, and increased the expression of Bax, cleavage of caspase 9, caspase 3, and PARP. As for cell differentiation, notopterol clearly induced chromatin condensation; increased the nucleocytoplasmic ratio, nitroblue tetrazolium-positive cells, expression of CD14 and CD11b, and protein expression of c-Jun and Jun B, and decreased c-myc. Furthermore, notopterol induced the G0/G1 cell-cycle arrest as determined using flow cytometry, which may be related to the regulation of cell-cycle-related proteins p53, CDK2, CDK4, Cyclin D1, Cyclin E, and survivin. The combined use of notopterol and ATRA did not enhance the apoptotic effect as evidenced by cell viability test and Hoechst 33342. However, the combination of notopterol and ATRA enhanced the effect of inducing differentiation when compared with using either notopterol or ATRA alone, which can be evidenced by the increased nucleocytoplasmic ratio, NBT positive cells, and expression of CD14. Conclusion: This is the first time it has been demonstrated that notopterol could induce apoptosis, differentiation, and G0/G1 arrest in human AML HL-60 cells, suggesting that notopterol has potential therapeutic effects on AML. The combination application of notopterol (20 and 40 μM) and ATRA (2 μM) could augment differentiation of HL-60 cells. Keywords: AML; apoptosis; cell growth; cycle arrest; differetiation; notopterol.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8217 mL 14.1084 mL 28.2167 mL 56.4334 mL 70.5418 mL
    5 mM 0.5643 mL 2.8217 mL 5.6433 mL 11.2867 mL 14.1084 mL
    10 mM 0.2822 mL 1.4108 mL 2.8217 mL 5.6433 mL 7.0542 mL
    50 mM 0.0564 mL 0.2822 mL 0.5643 mL 1.1287 mL 1.4108 mL
    100 mM 0.0282 mL 0.1411 mL 0.2822 mL 0.5643 mL 0.7054 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    佛手柑素; Bergamotine CFN90592 7380-40-7 C21H22O4 = 338.4 10mg QQ客服:3257982914
    羌活醇; Notopterol CFN98563 88206-46-6 C21H22O5 = 354.40 20mg QQ客服:1413575084
    羌活酚; Notoptol CFN95218 88206-49-9 C21H22O5 = 354.4 5mg QQ客服:1413575084
    环氧香柠檬素; Epoxybergamottin CFN70306 206978-14-5 C21H22O5 = 354.4 5mg QQ客服:2159513211
    6',7'-二羟薄荷素; 6',7'-Dihydroxybergamottin CFN98307 264234-05-1 C21H24O6 = 372.4 10mg QQ客服:2056216494
    6',7'-二羟薄荷素缩丙酮; 6',7'-Dihydroxybergamottin acetonide CFN97165 684217-08-1 C24H28O6 = 412.5 5mg QQ客服:215959384
    6'-羟基-7'-乙氧基香柠檬亭; 6'-Hydroxy-7'-ethoxybergamottin CFN97583 N/A C23H28O6 = 400.5 5mg QQ客服:2159513211
    8-氧甲基异欧前胡内酯; Cnidilin CFN90590 14348-22-2 C17H16O5 = 300.31 10mg QQ客服:1413575084
    氧化前胡素; Oxypeucedanin CFN90350 737-52-0 C16H14O5 = 286.28 20mg QQ客服:1413575084
    水合氧化前胡素; Oxypeucedanin hydrate CFN90557 2643-85-8 C16H16O6 = 304.29 20mg QQ客服:2159513211

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