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  • 1,3,6,7-四羟基氧杂蒽酮

    Norathyriol

    1,3,6,7-四羟基氧杂蒽酮
    产品编号 CFN98468
    CAS编号 3542-72-1
    分子式 = 分子量 C13H8O6 = 260.2
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Xanthones
    植物来源 The herbs of Mangifera indica L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    1,3,6,7-四羟基氧杂蒽酮 CFN98468 3542-72-1 1mg QQ客服:1413575084
    1,3,6,7-四羟基氧杂蒽酮 CFN98468 3542-72-1 5mg QQ客服:1413575084
    1,3,6,7-四羟基氧杂蒽酮 CFN98468 3542-72-1 10mg QQ客服:1413575084
    1,3,6,7-四羟基氧杂蒽酮 CFN98468 3542-72-1 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Technical University of Denmark (Denmark)
  • National Cancer Center Research Institute (Japan)
  • Hamdard University (India)
  • Universite de Lille1 (France)
  • University of Eastern Finland (Finland)
  • Julius Kühn-Institut (Germany)
  • Auburn University (USA)
  • University of Wollongong (Australia)
  • Universita' Degli Studi Di Cagliari (Italy)
  • University of British Columbia (Canada)
  • Aarhus University (Denmark)
  • University of Canterbury (New Zealand)
  • Stanford University (USA)
  • University of Toulouse (France)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Am J Chin Med.2016, 44(8):1719-1735
  • Journal of Research in Pharmacy.2022, 26(6):p1752-1757.
  • Cells.2021, 10(10):2633.
  • Acta Physiologiae Plantarum2015, 37:1736
  • Appl. Sci.2021, 11(24),12080
  • J Insect Sci.2020, 20(5):18.
  • Food Structure2023, 36:100324.
  • Plant J.2017, 90(3):535-546
  • Food Chem.2021, 360:130063.
  • Kaohsiung J Med Sci.2023, 10.1002/kjm2.12764
  • Nutrients.2021, 13(1):254.
  • Phytomedicine.2018, 47:48-57
  • Fitoterapia.2018, 124:92-102
  • The Catharanthus Genome2022,35-83.
  • J Ethnopharmacol.2020, 249:112381
  • J Ethnopharmacol.2019, 241:112025
  • J of Applied Pharmaceutical Science2020, 10(1):077-082
  • Int J Mol Sci.2022, 23(23):14826.
  • Chem Pharm Bull (Tokyo).2017, 65(9):826-832
  • Korean Journal of Pharmacognosy.2020, 51(2):100-106
  • Life (Basel).2022, 12(10):1630.
  • Food Control2022, 132:108434.
  • Chem Biol Interact.2018, 283:59-74
  • ...
  • 生物活性
    Description: Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability. Norathyriol as a safe new chemopreventive agent that is highly effective against development of UV-induced skin cancer. Norathyriol may be a dual, yet weak, cyclooxygenase and lipoxygenase pathway blocker, it has anti-inflammatory effect, and has inhibitory effect on the A23187-induced pleurisy and acetic acid-induced writhing response in mice. Norathyriol can relax the rat thoracic aorta mainly by suppressing the Ca2+ influx through both voltage-dependent and receptor-operated calcium channels. Norathyriol also can improve the glucose utilization and insulin sensitivity by up-regulation of the phosphorylation of AMPK.
    Targets: PKB | Akt | AMPK | AP-1 | ERK | NF-kB | PGE | COX | Calcium Channel | Potassium Channel | cAMP
    In vitro:
    Pharm Biol. 2014 Jan;52(1):68-73.
    Mangiferin and its aglycone, norathyriol, improve glucose metabolism by activation of AMP-activated protein kinase.[Pubmed: 24033319]
    Mangiferin has been reported to possess antidiabetic activities. Norathyriol, a xanthone aglycone, has the same structure as mangiferin, except for a C-glucosyl bond. To our best knowledge, no study has been conducted to determine and compare those two compounds on glucose consumption in vitro. In this study, the effects of Norathyriol and mangiferin on glucose consumption in normal and insulin resistance (IR) L6 myotubes were evaluated. Simultaneously, the potential mechanism of this effect was also investigated.
    METHODS AND RESULTS:
    Normal or IR L6 myotubes were incubated with Norathyriol (2.5 ∼ 10 μM, 0.625 ∼ 2.5 μM), mangiferin (10 ∼ 40 μM, 2.5 ∼ 10 μM) or rosiglitazone (20 μM) and/or 0.05 nM insulin for 24 h, respectively. The glucose consumption was assessed using the glucose oxidase method. Immunoblotting was performed to detect protein kinase B (PKB/Akt) and AMP-activated protein kinase (AMPK) phosphorylation in L6 myotubes cells. Norathyriol and mangiferin treatment alone increased the glucose consumption 61.9 and 56.3%, respectively, in L6 myotubes and made additional increasing with 0.05 nM insulin. In IR L6 myotubes, Norathyriol treatment made increasing with or without insulin, mangiferin treatment also made increasing but only when co-treated with insulin. Immunoblotting results showed that Norathyriol and mangiferin produced an increase of 1.9 - and 1.8-fold in the phosphorylation levels of the AMPK, but not in Akt.
    CONCLUSIONS:
    Our findings suggest that Norathyriol and mangiferin could improve the glucose utilization and insulin sensitivity by up-regulation of the phosphorylation of AMPK. Norathyriol may be considered as an active metabolite responsible for the antidiabetic activity of mangiferin.
    J Cancer Res Ther. 2012 Oct-Dec;8(4):561-4.
    Norathyriol suppresses transformation in JB6 P+ cells by the inhibition of Akt.[Pubmed: 23361275]
    Chemoprevention has been acknowledged as an important and practical strategy for the management of skin cancer. Norathyriol, a naturally occurring compound present in various plants, has a potent anticancer-promoting activity.The aim was to investigate the chemopreventive activity of Norathyriol on JB6 P+ cells.
    METHODS AND RESULTS:
    A soft agar assay was used to detect the effect of Norathyriol on cell transformation. The activator protein-1 (AP-1) transactivation activity was examined by the luciferase assay. Norathyriol inhibited epidermal growth factor (EGF)- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced neoplastic cell transformation in a dose-dependent manner. The activation of activator protein-1 was dose dependently suppressed by Norathyriol treatment. Western blot data revealed that Norathyriol attenuated the phosphorylation of Akt.
    CONCLUSIONS:
    Norathyriol exerts a potent chemopreventive activity by inhibiting Akt activation in neoplastic cell transformation.
    Cancer Res. 2012 Jan 1;72(1):260-70.
    Norathyriol suppresses skin cancers induced by solar ultraviolet radiation by targeting ERK kinases.[Pubmed: 22084399]
    Ultraviolet (UV) irradiation is the leading factor in the development of skin cancer, prompting great interest in chemopreventive agents for this disease.
    METHODS AND RESULTS:
    In this study, we report the discovery of Norathyriol, a plant-derived chemopreventive compound identified through an in silico virtual screening of the Chinese Medicine Library. Norathyriol is a metabolite of mangiferin found in mango, Hypericum elegans, and Tripterospermum lanceolatum and is known to have anticancer activity. Mechanistic investigations determined that Norathyriol acted as an inhibitor of extracellular signal-regulated kinase (ERK)1/2 activity to attenuate UVB-induced phosphorylation in mitogen-activated protein kinases signaling cascades. We confirmed the direct and specific binding of Norathyriol with ERK2 through a cocrystal structural analysis. The xanthone moiety in Norathyriol acted as an adenine mimetic to anchor the compound by hydrogen bonds to the hinge region of the protein ATP-binding site on ERK2. Norathyriol inhibited in vitro cell growth in mouse skin epidermal JB6 P+ cells at the level of G(2)-M phase arrest. In mouse skin tumorigenesis assays, Norathyriol significantly suppressed solar UV-induced skin carcinogenesis. Further analysis indicated that Norathyriol mediates its chemopreventive activity by inhibiting the ERK-dependent activity of transcriptional factors AP-1 and NF-κB during UV-induced skin carcinogenesis.
    CONCLUSIONS:
    Taken together, our results identify Norathyriol as a safe new chemopreventive agent that is highly effective against development of UV-induced skin cancer.
    Eur J Pharmacol. 1991 Jan 3;192(1):133-9.
    Vasorelaxation of rat thoracic aorta caused by norathyriol isolated from Gentianaceae.[Pubmed: 1645671]
    The pharmacological effects of Norathyriol on isolated rat thoracic aorta were examined.
    METHODS AND RESULTS:
    In the high-K+ (60 mM) medium, Ca2+ (0.03 to 3 mM)-induced vasocontraction was inhibited concentration dependently by Norathyriol. Given as pretreatment Norathyriol (20 to 200 microM) also inhibited the norepinephrine (NE, 3 microM)-induced tonic contraction. However, the phasic contraction was inhibited only by high concentrations of Norathyriol (200 and 400 microM). The tonic contraction elicited by NE was also relaxed by the addition of Norathyriol. This relaxing effect of Norathyriol was not antagonized by methylene blue (50 microM) or indomethacin (20 microM) and was still seen in denuded rat aorta. Although the cAMP level was not changed by Norathyriol, the cGMP level was increased by a high concentration of Norathyriol (400 microM). [3H]Inositol monophosphate formation caused by NE was not affected by Norathyriol at concentration of either 100 or 400 microM. The 45Ca2+ influx caused by either NE or high K+ was inhibited by Norathyriol in a concentration-dependent manner.
    CONCLUSIONS:
    It is concluded that Norathyriol relaxed the rat thoracic aorta mainly by suppressing the Ca2+ influx through both voltage-dependent and receptor-operated calcium channels.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.8432 mL 19.216 mL 38.432 mL 76.864 mL 96.0799 mL
    5 mM 0.7686 mL 3.8432 mL 7.6864 mL 15.3728 mL 19.216 mL
    10 mM 0.3843 mL 1.9216 mL 3.8432 mL 7.6864 mL 9.608 mL
    50 mM 0.0769 mL 0.3843 mL 0.7686 mL 1.5373 mL 1.9216 mL
    100 mM 0.0384 mL 0.1922 mL 0.3843 mL 0.7686 mL 0.9608 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3,8-二羟基-2,4,6-三甲氧基氧杂蒽酮; 3,8-Dihydroxy-2,4,6-trimethoxyxanthone CFN92556 65008-17-5 C16H14O7 = 318.3 5mg QQ客服:3257982914
    1,6,7-三羟基氧杂蒽酮; 1,6,7-Trihydroxyxanthone CFN98284 25577-04-2 C13H8O5 = 244.2 5mg QQ客服:1457312923
    1,3,6,7-四羟基氧杂蒽酮; Norathyriol CFN98468 3542-72-1 C13H8O6 = 260.2 5mg QQ客服:2159513211
    Montixanthone; Montixanthone CFN91903 876305-36-1 C14H10O6 = 274.23 5mg QQ客服:3257982914
    3,6-二羟基-1,7-二甲氧基呫吨酮; 3,6-Dihydroxy-1,7-dimethoxyxanthone CFN89303 262292-34-2 C15H12O6 = 288.25 5mg QQ客服:3257982914
    Onjixanthone II; Onjixanthone II CFN89276 136083-93-7 C15H12O7 = 304.25 5mg QQ客服:2159513211
    6-羟基-1,2,3,7-四甲氧基咕吨酮; 6-Hydroxy-1,2,3,7-tetramethoxyxanthone CFN89282 64756-87-2 C17H16O7 = 332.30 5mg QQ客服:215959384
    1,2,3,6,7-Pentamethoxyxanthone; 1,2,3,6,7-Pentamethoxyxanthone CFN89241 64756-86-1 C18H18O7 = 346.33 5mg QQ客服:2056216494
    狭花马钱碱 A; Angustin A CFN89373 1415795-50-4 C16H14O7 = 318.27 5mg QQ客服:3257982914
    狭花马钱碱 B; Angustin B CFN89374 1415795-51-5 C17H16O7 = 332.30 5mg QQ客服:2159513211

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