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  • 异去氧苦地胆苦素

    Isodeoxyelephantopin

    异去氧苦地胆苦素
    产品编号 CFN97745
    CAS编号 38927-54-7
    分子式 = 分子量 C19H20O6 = 344.36
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The herbs of Elephantopus scaber Linn.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异去氧苦地胆苦素 CFN97745 38927-54-7 1mg QQ客服:1413575084
    异去氧苦地胆苦素 CFN97745 38927-54-7 5mg QQ客服:1413575084
    异去氧苦地胆苦素 CFN97745 38927-54-7 10mg QQ客服:1413575084
    异去氧苦地胆苦素 CFN97745 38927-54-7 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Sanford Burnham Medical Research Institute (USA)
  • Shanghai Institute of Organic Chemistry (China)
  • Subang Jaya Medical Centre (Malaysia)
  • University of Brasilia (Brazil)
  • University of Cincinnati (USA)
  • University of Hawaii Cancer Center (USA)
  • Universidad Veracuzana (Mexico)
  • Indian Institute of Science (India)
  • Macau University of Science and Technology (China)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • Ateneo de Manila University (Philippines)
  • St. Jude Children Research Hospital (USA)
  • Florida International University (USA)
  • Uniwersytet Gdański (Poland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Ind Crops Prod.2015, 67:185-191
  • Journal of Oil Palm Research2019, 31(2):238-247
  • Cell Metab.2020, S1550-4131(20)30002-4
  • Oxid Med Cell Longev.2020, 2020:8887251.
  • J Appl Biol Chem2021, 64(3):245-251.
  • Mol Med Rep.2022, 25(1):8.
  • J Ethnopharmacol.2019, 235:406-414
  • ACS Synth Biol.2022, doi: 10.1021.
  • Biochem Biophys Res Commun.2017, 494(3-4):587-593
  • Molecules.2021, 26(13):4081.
  • J Appl Biol Chem.2021, 64(3),263?268
  • Mol Pharm.2018, 15(8):3285-3296
  • J Biosci.2020, 45:46.
  • Institute of Food Science & Technology2021, 45(9).
  • Molecules.2021, 26(8):2161.
  • Int J Mol Sci.2022, 23(21):13406.
  • Food Quality and Safety2018, 2:213-219
  • Front Pharmacol.2021, 12:635510.
  • Front Aging Neurosci.2019, 11:230
  • Br J Pharmacol.2020, 10.1111
  • Biochemistry.2018, 57(40):5886-5896
  • Plants (Basel).2021, 10(7):1376.
  • Plants (Basel).2022, 11(21):2947.
  • ...
  • 生物活性
    Description: Isodeoxyelephantopin exerts antitumor effects on several cancer cells by inducing apoptosis , cell cycle arrest , and inhibiting proliferation. It enhances apoptosis and inhibit invasion and osteoclastogenesis by inhibiting NF-kappaB activation and NF-kappaB-regulated gene expression.
    Targets: IFN-γ | ROS | IL Receptor | NF-kB | TNF-α | p65
    In vitro:
    Chin Med. 2014 Apr 17;9:14.
    Isodeoxyelephantopin from Elephantopus scaber (Didancao) induces cell cycle arrest and caspase-3-mediated apoptosis in breast carcinoma T47D cells and lung carcinoma A549 cells.[Pubmed: 24742378]

    METHODS AND RESULTS:
    Isodeoxyelephantopin (IDOE) isolated from Elephantopus scaber L. (Didancao) is used in Chinese medicine for the treatment of some types of cancer. The anti-cancer mechanism of Isodeoxyelephantopin remains unclear. This study aims to investigate the antiproliferative activity of Isodeoxyelephantopin on breast carcinoma T47D cells and lung carcinoma A549 cells. Isodeoxyelephantopininhibited the growth of A549 and T47D cells in a dose- and time-dependent manner with IC50 values of 10.46 and 1.3 μg/mL, respectively. Isodeoxyelephantopin was not significantly toxic to normal lymphocytes. The cells became detached from the monolayer and rounded up, had fragmented nuclei and condensed chromatin, and the numbers of apoptotic cells increased (P = 0.0003). Isodeoxyelephantopin-induced cell death was associated with activated caspase-3 expression followed by cell cycle arrest at G2/M phase.
    CONCLUSIONS:
    Isodeoxyelephantopin inhibited the proliferation of breast cancer cells and lung carcinoma cells and induced caspase-3-mediated apoptosis and cell cycle arrest in the treated cells.
    Clin Cancer Res. 2006 Oct 1;12(19):5910-8.
    Isodeoxyelephantopin, a novel sesquiterpene lactone, potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis through suppression of nuclear factor-kappaB (nf-kappaB) activation and nf-kappaB-regulated gene expression.[Pubmed: 17021000]
    Deoxyelephantopin (ESD) and Isodeoxyelephantopin (ESI) are two sesquiterpene lactones derived from the medicinal plant Elephantopus scaber Linn. We postulated that ESD and Isodeoxyelephantopin mediate their activities through modulation of the NF-kappaB activation pathway.
    METHODS AND RESULTS:
    We investigated the effect of Isodeoxyelephantopin and ESD on NF-kappaB activation by electrophoretic mobility shift assay and NF-kappaB-regulated gene expression by Western blot analysis. We found that Isodeoxyelephantopin suppressed NF-kappaB activation induced by a wide variety of inflammatory agents, including tumor necrosis factor (TNF), interleukin-1beta, phorbol 12-myristate 13-acetate, and lipopolysaccharide. Isodeoxyelephantopin did not interfere with the binding of NF-kappaB to DNA but rather inhibited IkappaBalpha kinase, IkappaBalpha phosphorylation, IkappaBalpha degradation, p65 phosphorylation, and subsequent p65 nuclear translocation. Isodeoxyelephantopin also suppressed the expression of TNF-induced NF-kappaB-regulated, proliferative, antiapoptotic, and metastatic gene products.
    CONCLUSIONS:
    Our results indicate that Isodeoxyelephantopin inhibits NF-kappaB activation and NF-kappaB-regulated gene expression, which may explain the ability of Isodeoxyelephantopin to enhance apoptosis and inhibit invasion and osteoclastogenesis.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.9039 mL 14.5197 mL 29.0394 mL 58.0788 mL 72.5984 mL
    5 mM 0.5808 mL 2.9039 mL 5.8079 mL 11.6158 mL 14.5197 mL
    10 mM 0.2904 mL 1.452 mL 2.9039 mL 5.8079 mL 7.2598 mL
    50 mM 0.0581 mL 0.2904 mL 0.5808 mL 1.1616 mL 1.452 mL
    100 mM 0.029 mL 0.1452 mL 0.2904 mL 0.5808 mL 0.726 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    2alpha-羟基泽兰内酯; 2-Hydroxyeupatolide CFN90346 72229-33-5 C15H20O4 = 264.32 5mg QQ客服:215959384
    表美国鹅掌楸内酯; Epitulipinolide CFN98252 24164-13-4 C17H22O4 = 290.4 5mg QQ客服:215959384
    小白菊内酯; Parthenolide CFN98034 20554-84-1 C15H20O3 = 248.3 20mg QQ客服:215959384
    鹅掌揪内酯; Lipiferolide CFN98642 41059-80-7 C17H22O5 = 306.4 5mg QQ客服:3257982914
    环氧表美国鹅掌楸内酯; Epitulipinolide diepoxide CFN98630 39815-40-2 C17H22O6 = 322.4 5mg QQ客服:215959384
    Heliangin; Heliangin CFN96222 13323-48-3 C20H26O6 = 362.4 5mg QQ客服:2056216494
    8beta-(4-Hydroxytigloyloxy)ovatifolin; 8beta-(4-Hydroxytigloyloxy)ovatifolin CFN96820 554449-27-3 C22H28O7 = 404.45 5mg QQ客服:1413575084
    Demethylsonchifolin; Demethylsonchifolin CFN97591 956384-55-7 C20H24O6 = 360.41 5mg QQ客服:2056216494
    Uvedalin; Uvedalin CFN97776 24694-79-9 C23H28O9 = 448.47 5mg QQ客服:2159513211
    沼菊素氯海德林; Enhydrin chlorohydrin CFN97746 38230-99-8 C23H29ClO10 = 500.93 5mg QQ客服:1413575084

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