N-对反式香豆酰酪胺

N-p-trans-Coumaroyltyramine

	产品编号	CFN98494
	CAS编号	36417-86-4
	分子式 = 分子量	C₁₇H₁₇NO₃ = 283.3
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Phenylpropanoids
	植物来源	The herbs of Exochorda racemosa.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
N-对反式香豆酰酪胺	CFN98494	36417-86-4	1mg	QQ客服：1457312923
N-对反式香豆酰酪胺	CFN98494	36417-86-4	5mg	QQ客服：1457312923
N-对反式香豆酰酪胺	CFN98494	36417-86-4	10mg	QQ客服：1457312923
N-对反式香豆酰酪胺	CFN98494	36417-86-4	20mg	QQ客服：1457312923

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Pretoria (South Africa)

Universidade de Franca (Brazil)

Utrecht University (Netherlands)

University of Limpopo (South Africa)

Aveiro University (Portugal)

Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)

Universidade Católica Portuguesa (Portugal)

Universita' Degli Studi Di Cagliari (Italy)

Lodz University of Technology (Poland)

University of Illinois at Chicago (USA)

Martin Luther University of Halle-Wittenberg (Germany)

Institute of Tropical Disease Universitas Airlangga (Indonesia)

Chang Gung University (Taiwan)

Max-Planck-Insitut (Germany)

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Description:

N-p-trans-Coumaroyltyramine is an inhibitor on acetylcholinesterase (AChE), it inhibits AChE activity in a dose-dependent manner with IC50 value of 34.5 microg/mL (122 microM). It exhibits potent inhibition of cell proliferation, platelet aggregation, and shows antioxidant activity. N-trans-p-coumaroyltyramine shows activity against Trypanosoma brucei rhodesiense (IC50s ranging from 2.2 to 13.3 microM).

Targets:

AChR

In vitro:

Arch. Pharm. Res.,2003, 26(9):735-8.

Inhibitory effect of trans-N-p-coumaroyl tryamine from the twigs of Celtis chinensis on the acetylcholinesterase.[Pubmed: 14560923]

METHODS AND RESULTS:
The methanolic extract of the twigs of Celtis chinensis was found to show inhibitory activity on acetylcholinesterase (AChE), an enzyme that plays a role in the metabolic hydrolysis of ACh. Bioassay-guided fractionation of the methanolic extract resulted in the isolation of N-p-trans-Coumaroyltyramine, as an inhibitor on AChE.
CONCLUSIONS:
This compound inhibited AChE activity in a dose-dependent manner, and the IC50 value of N-p-trans-Coumaroyltyramine was 34.5 microg/mL (122 microM).

Nat Prod Commun. 2012 Jun;7(6):753-5.

Cinnamoylphenethyl amides from Polygonum hyrcanicum possess anti-trypanosomal activity.[Pubmed: 22816300]

METHODS AND RESULTS:
A methanolic extract from aerial parts of Polygonum hyrcanicum (Polygonaceae) showed high activity against Trypanosoma brucei rhodesiense (IC50 = 3.7 microg/mL). Bioassay-guided fractionation of the extract resulted in isolation of cinnamoylphenethyl amides, including N-trans-caffeoyltyramine (1), N-p-trans-Coumaroyltyramine (7), and N-trans-feruloyltyramine (8) as the main active constituents (IC50s ranging from 2.2 to 13.3 microM). Some structurally related, but less active compounds, such as cannabisin B (2), tyrosol (3), p-coumaric acid (4), ferulic acid (5), and N-cis-feruloyltyramine (6) were also identified, along with N-trans-3,4-dimethoxycinnamoyldopamine (9).
CONCLUSIONS:
Cytotoxicity of the active compounds in L6 cells was determined, and selectivity indices (SI) of 7.9 to 33.4 were calculated.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
3-[3,4-双(乙酰氧基)苯基]-2-丙烯酰胺; 3,4-Diacetoxycinnamamide	CFN99390	129488-34-2	C₁₃H₁₃NO₅ = 263.3	5mg	QQ客服：1457312923
阿魏酸酰胺; Ferulamide	CFN97041	61012-31-5	C₁₀H₁₁NO₃ = 193.2	5mg	QQ客服：2056216494
印枳碱; Aegeline	CFN91133	456-12-2	C₁₈H₁₉NO₃ = 297.4	20mg	QQ客服：2056216494
N-咖啡酰O-甲基酪胺; N-Caffeoyl O-methyltyramine	CFN70295	189307-47-9	C₁₈H₁₉NO₄ = 313.4	5mg	QQ客服：3257982914
N-反式咖啡酰真蛸胺; N-trans-caffeoyloctopamine	CFN95264	1378868-10-0	C₁₇H₁₇NO₅ = 315.3	5mg	QQ客服：2056216494
N-反式咖啡酰酪胺; N-trans-caffeoyltyramine	CFN95265	103188-48-3	C₁₇H₁₇NO₄ = 299.3	5mg	QQ客服：1457312923
N-反式阿魏酰酪胺; N-trans-Feruloyltyramine	CFN97135	66648-43-9	C₁₈H₁₉NO₄ = 313.4	10mg	QQ客服：2159513211
蒺藜酰胺; Terrestriamide	CFN95789	157536-49-7	C₁₈H₁₇NO₅ = 327.3	5mg	QQ客服：1413575084
顺式-N-蒺藜酰胺; cis-N-Terrestriamide	CFN95795	2170469-93-7	C₁₈H₁₇NO₅ = 327.3	5mg	QQ客服：1413575084
N-反式-阿魏酰-3-甲氧基酪胺; N-trans-Feruloyl-3-methoxytyramine	CFN97268	78510-19-7	C₁₉H₂₁NO₅ = 343.4	5mg	QQ客服：1457312923

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.5298 mL	17.6491 mL	35.2983 mL	70.5965 mL	88.2457 mL
5 mM	0.706 mL	3.5298 mL	7.0597 mL	14.1193 mL	17.6491 mL
10 mM	0.353 mL	1.7649 mL	3.5298 mL	7.0597 mL	8.8246 mL
50 mM	0.0706 mL	0.353 mL	0.706 mL	1.4119 mL	1.7649 mL
100 mM	0.0353 mL	0.1765 mL	0.353 mL	0.706 mL	0.8825 mL