N-Demethyl-alpha-obscurine

	产品编号	CFN89068
	CAS编号	34399-44-5
	分子式 = 分子量	C₁₆H₂₄N₂O = 260.38
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Alkaloids
	植物来源	The whole plants of Lycopodium japonicum.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
N-Demethyl-alpha-obscurine	CFN89068	34399-44-5	1mg	QQ客服：2056216494
N-Demethyl-alpha-obscurine	CFN89068	34399-44-5	5mg	QQ客服：2056216494
N-Demethyl-alpha-obscurine	CFN89068	34399-44-5	10mg	QQ客服：2056216494
N-Demethyl-alpha-obscurine	CFN89068	34399-44-5	20mg	QQ客服：2056216494

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)

Sapienza University of Rome (Italy)

University of Otago (New Zealand)

Tokyo Woman's Christian University (Japan)

Regional Crop Research Institute (Korea)

Medical University of South Carolina (USA)

Celltrion Chemical Research Institute (Korea)

Institute of Tropical Disease Universitas Airlangga (Indonesia)

University of Limpopo (South Africa)

Chang Gung University (Taiwan)

University of Lodz (Poland)

Seoul National University (Korea)

Kamphaengphet Rajabhat University (Thailand)

Shanghai Institute of Biochemistry and Cell Biology (China)

More...

Description:

N-Demethyl-alpha-obscurine is a natural product from Lycopodium japonicum.

In vitro:

Chinese Traditional & Herbal Drugs, 2015, 46(9):1269-1276.

Lycopodium alkaloids from Lycopodium japonicum.[Reference: WebLink]

To study the chemical constituents in the whole herb of Lycopodium japonicum.
METHODS AND RESULTS:
The constituents were isolated and purified by silica gel and semi-preparative HPLC, and their structures were elucidated by means of physicochemical properties and spectroscopic analysis. All the isolated compounds were evaluated using relevant in vitro anti-inflammatory assay against LPS-induced NO releases.Nineteen compounds were isolated from the whole herb of L. japonicum, and identified as lycoposerramine-M N-oxide (1), acetyllycoposerramine-M (2), lycopodine (3), lycoposerramine-M (4), miyoshianine-C (5), 12-epilycodoline N-oxide (6), gnidioidine (7), lycoposerramine-K (8), lucidioline (9), 4α-hydroxyanhydrolycodoline (10), flabelline (11), hydroxypropyllycodine (12), lycodine (13), des-N-methyl-α-obscurine (N-Demethyl-alpha-obscurine,14), α-obscurine (15), des-N-methyl-β-obscurine (16), lycoflexine (17), lycoflexine N-oxide (18), and fawcettidine (19). Compound 5 and 18 could inhibit the release of nitric oxide (NO) in the RAW264.7 cell line stimulated by lipopolysaccaride. The IC50 values of 5 and 18 are 31.82 and 40.69 μmol/L, respectively.
CONCLUSIONS:
Compound 1 is a new compound, named lycoposerramine-M N-oxide, compounds 2, 6, 11, 12, 16, 18, and 19 are isolated from this plant for the first time. Compounds 5 and 18 exhibit the potent inhibitory activity.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
石杉碱丙; Huperzine C	CFN90345	163089-71-2	C₁₅H₁₈N₂O = 242.32	5mg	QQ客服：2159513211
石杉碱甲; Huperzine A	CFN99959	120786-18-7	C₁₅H₁₈N₂O = 242.32	20mg	QQ客服：2056216494
石杉碱乙; Huperzine B	CFN99960	103548-82-9	C₁₆H₂₀N₂O = 256.35	20mg	QQ客服：3257982914
N-Demethyl-alpha-obscurine; N-Demethyl-alpha-obscurine	CFN89068	34399-44-5	C₁₆H₂₄N₂O = 260.38	5mg	QQ客服：2056216494
α-玉柏碱; Alpha-Obscurine	CFN96411	596-55-4	C₁₇H₂₆N₂O = 274.4	5mg	QQ客服：215959384
Lucidioline; Lucidioline	CFN89120	22594-91-8	C₁₆H₂₅NO₂ = 263.38	5mg	QQ客服：1457312923
6alpha-Hydroxylycopodine; 6alpha-Hydroxylycopodine	CFN89109	21061-92-7	C₁₆H₂₅NO₂ = 263.38	5mg	QQ客服：3257982914
石斛碱; Dendrobine	CFN99133	2115-91-5	C₁₆H₂₅NO₂ = 263.38	20mg	QQ客服：1413575084
3-氯-4-羟基哌啶-2-酮; 3-Chloro-4-hydroxypiperidin-2-one	CFN96086	174204-83-2	C₅H₈ClNO₂ = 149.6	5mg	QQ客服：2159513211
5,6-二氢-2(1H)-吡啶酮; 5,6-Dihydropyridin-2(1H)-one	CFN96112	6052-73-9	C₅H₇NO = 97.1	5mg	QQ客服：215959384

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.8405 mL	19.2027 mL	38.4054 mL	76.8108 mL	96.0135 mL
5 mM	0.7681 mL	3.8405 mL	7.6811 mL	15.3622 mL	19.2027 mL
10 mM	0.3841 mL	1.9203 mL	3.8405 mL	7.6811 mL	9.6014 mL
50 mM	0.0768 mL	0.3841 mL	0.7681 mL	1.5362 mL	1.9203 mL
100 mM	0.0384 mL	0.192 mL	0.3841 mL	0.7681 mL	0.9601 mL