Info: Read More
  • 中药标准品生产商,产品定制服务
  • 杨梅醇

    Myricanol

    杨梅醇
    产品编号 CFN98430
    CAS编号 33606-81-4
    分子式 = 分子量 C21H26O5 = 358.4
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Phenols
    植物来源 The root barks of Myrica cerifera L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    杨梅醇 CFN98430 33606-81-4 1mg QQ客服:1413575084
    杨梅醇 CFN98430 33606-81-4 5mg QQ客服:1413575084
    杨梅醇 CFN98430 33606-81-4 10mg QQ客服:1413575084
    杨梅醇 CFN98430 33606-81-4 20mg QQ客服:1413575084
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Michigan State University (USA)
  • University of Hawaii Cancer Center (USA)
  • Gyeongsang National University (Korea)
  • University of Sao Paulo (Brazil)
  • Universit?t Basel (Switzerland)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • Universidade Católica Portuguesa (Portugal)
  • Lodz University of Technology (Poland)
  • University of Bordeaux (France)
  • Griffith University (Australia)
  • Chinese University of Hong Kong (China)
  • University of Fribourg (Switzerland)
  • Mahatma Gandhi University (India)
  • The Vancouver Prostate Centre (VPC) (Canada)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Trop J Pharm Res.2023, 22(3):283-288.
  • FASEB J.2022, 36(7):e22387.
  • JEJU National University2022, 24032.
  • Front Pharmacol.2021, 12:615157.
  • Viruses.2017, 9(10)
  • Mol Pharm.2017, 14(9):3164-3177
  • Foods. 2022, 11(23):3905.
  • Molecules.2020 ,25(16):3697.
  • Korean J. Medicinal Crop Sci.2021, 29(1):45-50.
  • Journal of Ginseng Research2021, 3 June.
  • Nutrients2022, 14(3),695.
  • Int J Mol Sci.2021, 22(11):5503.
  • Food Chem.2023, 404(Pt A):134517.
  • JMicrobiol Biotech Food Sci2021, e4289.
  • Cell Physiol Biochem.2017, 43(4):1425-1435
  • Oxid Med Cell Longev.2022, 2022:9139338.
  • Sains Malaysiana2022, 51(4):1143-1154
  • Phytomedicine.2018, 47:48-57
  • Evid Based Complement Alternat Med.2018, 2018:4259603
  • Nutrients.2017, 10(1)
  • Pharmacognosy Journal2019, 11(2): 369-373
  • Appl. Sci.2020, 10(8),2804
  • Sci Rep. 2018, 1-9
  • ...
  • 生物活性
    Description: Myricanol can elicit growth inhibitory and cytotoxic effects on lung cancer cells, it can significantly decelerate tumor growth in vivo by inducing apoptosis.
    Targets: Caspase | Bcl-2/Bax | p21 | VEGFR | HIF
    In vitro:
    Phytomedicine. 2014 Sep 25;21(11):1490-6.
    Growth-inhibiting and apoptosis-inducing activities of Myricanol from the bark of Myrica rubra in human lung adenocarcinoma A549 cells.[Pubmed: 24939078 ]
    This study investigated whether or not Myricanol extracted from M. rubra bark elicits anti-cancer effects on human lung adenocarcinoma A549 cells by inducing apoptosis in vivo.
    METHODS AND RESULTS:
    Myricanol was extracted from M. rubra bark through system solvent extraction and silica gel layer column separation. The results of tritiated thymidine assay, colony formation assay, and flow cytometry indicated that Myricanol inhibited the growth of A549 cells. The effects of Myricanol on the expression of key apoptosis-related genes in A549 cells were evaluated by quantitative PCR and Western blot analyses. Myricanol significantly inhibited the growth of A549 cells in a dose-dependent manner, with a half maximal inhibitory concentration of 4.85 μg/ml. Myricanol significantly decreased colony formation and induced A549 cell apoptosis. Myricanol upregulated the expression of Caspase-3, Caspase-9, Bax, and p21 and downregulated the expression of Bcl-2 at the mRNA and protein levels.
    CONCLUSIONS:
    These changes were associated with apoptosis. Based on these results, we propose that Myricanol elicits growth inhibitory and cytotoxic effects on lung cancer cells. Therefore, Myricanol may be a clinical candidate for the prevention and treatment of lung cancer.
    ACS Chem Biol. 2015 Apr 17;10(4):1099-109.
    Synthesis, stereochemical analysis, and derivatization of myricanol provide new probes that promote autophagic tau clearance.[Pubmed: 25588114]
    We previously discovered that one specific scalemic preparation of Myricanol (1), a constituent of Myrica cerifera (bayberry/southern wax myrtle) root bark, could lower the levels of the microtubule-associated protein tau (MAPT). The significance is that tau accumulates in a number of neurodegenerative diseases, the most common being Alzheimer's disease (AD).
    METHODS AND RESULTS:
    Herein, a new synthetic route to prepare Myricanol using a suitable boronic acid pinacol ester intermediate is reported. An X-ray crystal structure of the isolated Myricanol (1) was obtained and showed a co-crystal consisting of (+)-aR,11S-Myricanol (2) and (-)-aS,11R-Myricanol (3) coformers. Surprisingly, 3, obtained from chiral separation from 1, reduced tau levels in both cultured cells and ex vivo brain slices from a mouse model of tauopathy at reasonable mid-to-low micromolar potency, whereas 2 did not. SILAC proteomics and cell assays revealed that 3 promoted tau degradation through an autophagic mechanism, which was in contrast to that of other tau-lowering compounds previously identified by our group.
    CONCLUSIONS:
    During the course of structure-activity relationship (SAR) development, we prepared compound 13 by acid-catalyzed dehydration of 1. 13 had undergone an unexpected structural rearrangement through the isoMyricanol substitution pattern (e.g., 16), as verified by X-ray structural analysis. Compound 13 displayed robust tau-lowering activity, and, importantly, its enantiomers reduced tau levels similarly.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7902 mL 13.9509 mL 27.9018 mL 55.8036 mL 69.7545 mL
    5 mM 0.558 mL 2.7902 mL 5.5804 mL 11.1607 mL 13.9509 mL
    10 mM 0.279 mL 1.3951 mL 2.7902 mL 5.5804 mL 6.9754 mL
    50 mM 0.0558 mL 0.279 mL 0.558 mL 1.1161 mL 1.3951 mL
    100 mM 0.0279 mL 0.1395 mL 0.279 mL 0.558 mL 0.6975 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    杨梅醇; Myricanol CFN98430 33606-81-4 C21H26O5 = 358.4 5mg QQ客服:215959384
    杨梅酮; Myricanone CFN98413 32492-74-3 C21H24O5 = 356.4 5mg QQ客服:2056216494
    12-羟基杨梅酮; 12-Hydroxymyricanone CFN91926 191999-68-5 C21H24O6 = 372.41 5mg QQ客服:1413575084
    Porson; Porson CFN98939 56222-03-8 C22H26O6 = 386.4 5mg QQ客服:2159513211
    (+)-S-杨梅醇葡萄糖甙; (+)-S-Myricanol glucoside CFN98683 449729-89-9 C27H36O10 = 520.6 5mg QQ客服:3257982914
    三乙酸杨梅醇酯; Myricanol triacetate CFN98455 34509-52-9 C27H32O8 = 484.6 5mg QQ客服:1457312923
    Myricananin A; Myricananin A CFN99086 1079941-35-7 C20H24O5 = 344.4 5mg QQ客服:2056216494
    赤杨二醇; Alnusdiol CFN96235 56973-51-4 C19H22O4 = 314.4 5mg QQ客服:3257982914
    赤杨酮; Alnusone CFN89536 52330-11-7 C19H18O3 = 294.4 5mg QQ客服:1457312923
    Carpinontriol B; Carpinontriol B CFN89541 473451-73-9 C19H20O6 = 344.35 5mg QQ客服:1413575084

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产