| In vitro: |
| Bioinformation. 2012;8(24):1206-10. | | Virtual screening of Indonesian herbal database as HIV-1 reverse transcriptase inhibitor.[Pubmed: 23275721] | HIV-1 (Human immunodeficiency virus type 1) is a member of retrovirus family that could infect human and causing AIDS disease. AIDS epidemic is one of most destructive diseases in modern era. There were more than 33 million people infected by HIV until 2010. Various studies have been widely employed to design drugs that target the essential enzymes of HIV-1 that is, reverse transcriptase, protease and integrase.
METHODS AND RESULTS:
In this study, in silico virtual screening approach is used to find lead molecules from the library or database of natural compounds as HIV-1 reverse transcriptase inhibitor. Virtual screening against Indonesian Herbal Database using AutoDock4 performed on HIV-1 reverse transcriptase.
CONCLUSIONS:
From the virtual screening, top ten compounds were mulberrin, plucheoside A, vitexilactone, brucine N-oxide, cyanidin 3-arabinoside, alpha-mangostin, guaijaverin, erycristagallin, morusin and sanggenol N. |
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| In vivo: |
| Journal of Traditional Chinese Medicine University of Hunan, 2011, 31(5):26-8. | | Experimental study of mulberrin on blood glucose of Type Ⅱ diabetes model rats.[Reference: WebLink] | The experiment had investigated the results by using mulberrin on blood glucose,insulin,glycated hemoglobin,glucose tolerance of Type II diabetes model rats.
METHODS AND RESULTS:
According to Chinese herbal medicine research guide(oral) pharmacodynamics experiment demands,choose the normal mice(KM mice),spontaneous diabetic mice(NOD mice) and chain fosomycin heightening urea to heat feed type II diabetes rats,fill the stomach give different doses of mulberry element,research on the blood glucose,insulin,glycated hemoglobin influence.1.The concentration of blood glucose of regular lab rats has no visibly changed(P0.05)after using mulberrin of 50.0,25.0,12.5 mg/kg by oral administration for 14 days.By contrast,the blood glucose were obviously lower and rates of Insulin were obviously higher(P0.05) in NOD rats.2.The concentration of blood glucose of has reduced obviously after using mulberrin of 30.0,15.0,7.5 mg/kg).Compare with the regular group,the rates of Insulin and Glycosylated Hemoglobin were obviously lower(P0.05) after using mulberrin of 30,15 mg/kg by oral administration for 14 days.
CONCLUSIONS:
Mulberrin has significantly reduced role on blood sugar of type II diabetes model of rats. |
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