苏荠宁黄酮; 5-羟基-7,8-二甲氧基黄酮

Moslosooflavone

	产品编号	CFN98475
	CAS编号	3570-62-5
	分子式 = 分子量	C₁₇H₁₄O₅ = 298.3
	产品纯度	>=98%
	物理属性	Yellow powder
	化合物类型	Flavonoids
	植物来源	The herbs of Mosla soochouensis Matsuda
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
苏荠宁黄酮; 5-羟基-7,8-二甲氧基黄酮	CFN98475	3570-62-5	10mg	QQ客服：215959384
苏荠宁黄酮; 5-羟基-7,8-二甲氧基黄酮	CFN98475	3570-62-5	20mg	QQ客服：215959384
苏荠宁黄酮; 5-羟基-7,8-二甲氧基黄酮	CFN98475	3570-62-5	50mg	QQ客服：215959384
苏荠宁黄酮; 5-羟基-7,8-二甲氧基黄酮	CFN98475	3570-62-5	100mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Centrum Menselijke Erfelijkheid (Belgium)

University of Bordeaux (France)

University of Leipzig (Germany)

University of Liège (Belgium)

National Cancer Center Research Institute (Japan)

Universitas islam negeri Jakarta (Indonesia)

The Vancouver Prostate Centre (VPC) (Canada)

Donald Danforth Plant Science Center (USA)

Florida A&M University (USA)

St. Jude Children Research Hospital (USA)

Cancer Research Initatives Foundation(CARIF) (Malaysia)

Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)

University of Bonn (Germany)

University of Oslo (Norway)

More...

Description:

Moslosooflavone has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice. Moslosooflavone significantly inhibits the transcriptional activity of NF-kappaB in LPS/IFN-gamma stimulated RAW 264.7 macrophages.

Targets:

NF-kB | IFN-γ | IL Receptor | NO | TNF-α

In vitro:

J Agric Food Chem. 2010 Feb 24;58(4):2505-12.

Anti-inflammatory activity of new compounds from Andrographis paniculata by NF-kappaB transactivation inhibition.[Pubmed: 20085279]

Previous studies showed that the ethyl acetate (EtOAc) fraction of Andrographis paniculata (AP) possessed anti-inflammatory activity. This study further isolated these active compounds from bioactivity-guided chromatographic fractionation and identified eight pure compounds.
METHODS AND RESULTS:
Reporter gene assay indicated that 5-hydroxy-7,8-dimethoxyflavone (1), Moslosooflavone (2), a mix of beta-sitosterol (3a) and stigmasterol (3b), ergosterol peroxide (4), 14-deoxy-14,15-dehydroandrographolide (5), and a new compound, 19-O-acetyl-14-deoxy-11,12-didehydroandrographolide (6a), significantly inhibited the transcriptional activity of NF-kappaB in LPS/IFN-gamma stimulated RAW 264.7 macrophages (P < 0.05). The two most abundant compounds, 14-deoxy-11,12-didehydroandrographolide (7) and andrographolide (8), had less inhibitory activity but exerted greater inhibitory activity by hydrogenation, oxidation, or acetylation to become four derived compounds, 9, 10, 11, and 12. All of the compounds significantly decreased TNF-alpha, IL-6, macrophage inflammatory protein-2 (MIP-2), and nitric oxide (NO) secretions from LPS/IFN-gamma stimulated RAW 264.7 cells. Compounds 5, 11, and 12 exerted the strongest inhibitory effect on NF-kappaB-dependent transactivation in the RAW 264.7 cell, with IC(50) values of 2, 2.2, and 2.4 microg/mL, respectively, providing encouraging results for bioactive compound development.

In vivo:

Zhong Yao Cai. 2015 Jan;38(1):89-92.

Chemical Constituents with Anti-hypoxia Activity from Saussurea involucrata.[Pubmed: 26214875]

To investigate the chemical constituents with anti-hypoxia activity from Saussurea involucrata.
METHODS AND RESULTS:
The chemical constituents, isolated and purified by column chromatography from Saussurea involucrata, were identified by several spectroscopic methods. The anti-hypoxic activities of these compounds were examined using the normobaric hypoxic model of mice. Twelve compounds were isolated from petroleum ether extract of Saussurea involucrata and identified as n-octacosane (1), 1-undecanol (2), heptadecan-l-ol(3), heptacosan-1-ol(4), myristicin (5), apiol(6), β-sitosterol(7), lupeol(8), moslosooflavone (9), mosloflavone (10), negletein(11), and 5, 6-dihydroxy-7, 8-dimethoxyflavone(12).
CONCLUSIONS:
All compounds except 7 and 8 are isolated from this plant for the first time. Compound 1, 5 and 8 - 12 can significantly prolong the survival time of hypoxic mice.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
5,7,8-三甲氧基去甲汉黄芩素; Norwogonin 5,7,8-trimethyl ether	CFN91074	23050-38-6	C₁₈H₁₆O₅ = 312.3	10mg	QQ客服：2159513211
黄芩素；黄芩苷元; Baicalein	CFN98783	491-67-8	C₁₅H₁₀O₅ = 270.2	20mg	QQ客服：1413575084
千层纸素A; Oroxylin A	CFN98540	480-11-5	C₁₆H₁₂O₅ = 284.26	20mg	QQ客服：215959384
7-甲醚黄芩素; Negletein	CFN91886	29550-13-8	C₁₆H₁₂O₅ = 284.26	5mg	QQ客服：2159513211
荠苧黄酮; Mosloflavone	CFN90893	740-33-0	C₁₇H₁₄O₅ = 298.3	20mg	QQ客服：2056216494
6-羟基汉黄芩素; 6-Hydroxywogonin	CFN95009	76844-70-7	C₁₆H₁₂O₆ = 300.3	5mg	QQ客服：215959384
5,7-二羟基-6,8-二甲氧基黄酮; 6-Methoxywogonin	CFN98403	3162-45-6	C₁₇H₁₄O₆ = 314.3	5mg	QQ客服：215959384
6-甲氧基黄酮; 6-Methoxyflavone	CFN70090	26964-24-9	C₁₆H₁₂O₃ = 252.2	20mg	QQ客服：1413575084
6,7-二羟基黄酮; 6,7-Dihydroxyflavone	CFN70351	38183-04-9	C₁₅H₁₀O₄ = 254.2	20mg	QQ客服：2159513211
3,6-二羟基黄酮; 3,6-Dihydroxyflavone	CFN70020	108238-41-1	C₁₅H₁₀O₄ = 254.2	20mg	QQ客服：2056216494

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.3523 mL	16.7616 mL	33.5233 mL	67.0466 mL	83.8082 mL
5 mM	0.6705 mL	3.3523 mL	6.7047 mL	13.4093 mL	16.7616 mL
10 mM	0.3352 mL	1.6762 mL	3.3523 mL	6.7047 mL	8.3808 mL
50 mM	0.067 mL	0.3352 mL	0.6705 mL	1.3409 mL	1.6762 mL
100 mM	0.0335 mL	0.1676 mL	0.3352 mL	0.6705 mL	0.8381 mL

苏荠宁黄酮; 5-羟基-7,8-二甲氧基黄酮

Moslosooflavone

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