6,7-二羟基黄酮

6,7-Dihydroxyflavone

	产品编号	CFN70351
	CAS编号	38183-04-9
	分子式 = 分子量	C₁₅H₁₀O₄ = 254.2
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Flavonoids
	植物来源	The roots of Pueraria lobata
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
6,7-二羟基黄酮	CFN70351	38183-04-9	10mg	QQ客服：215959384
6,7-二羟基黄酮	CFN70351	38183-04-9	20mg	QQ客服：215959384
6,7-二羟基黄酮	CFN70351	38183-04-9	50mg	QQ客服：215959384
6,7-二羟基黄酮	CFN70351	38183-04-9	100mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Wollongong (Australia)

National Cancer Institute (USA)

University of Hawaii Cancer Center (USA)

Mahatma Gandhi University (India)

Osmania University (India)

Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)

The Institute of Cancer Research (United Kingdom)

Max Rubner-Institut (MRI) (Germany)

Universidad Miguel Hernández (Spain)

Korea Institute of Oriental Medicine (Korea)

University of Bonn (Germany)

Florida A&M University (USA)

University of Amsterdam (Netherlands)

University of Otago (New Zealand)

More...

Description:

6,7-Dihydroxyflavone has fee radical scavenging activity. 6,7-Dihydroxyflavone by itself has only a weak antibacterial effect on methicillin-resistant Staphylococcus aureus (MRSA).

Targets:

Antifection

In vitro:

Quantitative Structure Activity Relationships, 2000, 19(1):50-53.

Theoretical Investigation on Free Radical Scavenging Activity of 6,7‐Dihydroxyflavone.[Reference: WebLink]

METHODS AND RESULTS:
The difference of heat of formation between parent molecule and its free radical (ΔHOF), calculated by semiempirical quantum chemical method AM1, was employed as a theoretical index to characterize the O–H bond dissociation energy (BDE) of antioxidant. Through a comparison between ΔHOF of model molecules, it was found that 6,7‐dihydroxyflavone (DHF) possessed two favorable structural factors, the presence of ortho hydroxyls and the existence of para oxygen, to weaken its O–H bond at position 6, but the passive effect produced by electron‐withdrawing property of the chromonoid ring C surpassed the active effect of the para oxygen. Therefore the free radical scavenging activity of DHF was lower than that of quercetin which possessed catecholic hydroxyl in ring B and was scarcely influenced by ring C.
CONCLUSIONS:
As a result of the analysis, two more active flavonoid antioxidants were constructed theoretically.

Antimicrobial Agents and Chemotherapy, 01 Apr 2004, 48(4):1357-1360.

6,7-Dihydroxyflavone Dramatically Intensifies the Susceptibility of Methicillin-Resistant or -Sensitive Staphylococcus aureus to -Lactams.[Reference: WebLink]

METHODS AND RESULTS:
We have demonstrated that 6,7-dihydroxyflavone by itself has only a weak antibacterial effect on methicillin-resistant Staphylococcus aureus (MRSA) but that at concentrations less than MIC it synergistically elevates the susceptibility of clinically isolated MRSA and methicillin-sensitive S. aureus strains to beta-lactam antibiotics from 8- to 32,800-fold.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
汉黄芩素; Wogonin	CFN97089	632-85-9	C₁₆H₁₂O₅ = 284.3	20mg	QQ客服：2056216494
5-羟基-7-乙酰氧基-8-甲氧基黄酮; 5-Hydroxy-7-acetoxy-8-methoxyflavone	CFN97535	95480-80-1	C₁₈H₁₄O₆ = 326.3	5mg	QQ客服：2159513211
5,7-二羟基-8-甲氧基黄酮二乙酸酯; 5,7-Diacetoxy-8-methoxyflavone	CFN98240	23246-80-2	C₂₀H₁₆O₇ = 368.3	5mg	QQ客服：2159513211
苏荠宁黄酮; 5-羟基-7,8-二甲氧基黄酮; Moslosooflavone	CFN98475	3570-62-5	C₁₇H₁₄O₅ = 298.3	20mg	QQ客服：3257982914
5,7,8-三甲氧基去甲汉黄芩素; Norwogonin 5,7,8-trimethyl ether	CFN91074	23050-38-6	C₁₈H₁₆O₅ = 312.3	10mg	QQ客服：2159513211
黄芩素；黄芩苷元; Baicalein	CFN98783	491-67-8	C₁₅H₁₀O₅ = 270.2	20mg	QQ客服：3257982914
千层纸素A; Oroxylin A	CFN98540	480-11-5	C₁₆H₁₂O₅ = 284.26	20mg	QQ客服：1413575084
7-甲醚黄芩素; Negletein	CFN91886	29550-13-8	C₁₆H₁₂O₅ = 284.26	5mg	QQ客服：215959384
荠苧黄酮; Mosloflavone	CFN90893	740-33-0	C₁₇H₁₄O₅ = 298.3	20mg	QQ客服：1457312923
6-羟基汉黄芩素; 6-Hydroxywogonin	CFN95009	76844-70-7	C₁₆H₁₂O₆ = 300.3	5mg	QQ客服：1413575084

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.9339 mL	19.6696 mL	39.3391 mL	78.6782 mL	98.3478 mL
5 mM	0.7868 mL	3.9339 mL	7.8678 mL	15.7356 mL	19.6696 mL
10 mM	0.3934 mL	1.967 mL	3.9339 mL	7.8678 mL	9.8348 mL
50 mM	0.0787 mL	0.3934 mL	0.7868 mL	1.5736 mL	1.967 mL
100 mM	0.0393 mL	0.1967 mL	0.3934 mL	0.7868 mL	0.9835 mL