Monomethyl kolavate

	产品编号	CFN98262
	CAS编号	24513-41-5
	分子式 = 分子量	C₂₁H₃₂O₄ = 348.5
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Diterpenoids
	植物来源	The woods of Gossweilerodendron balsamiferum
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

提供自定义包装

产品名称	产品编号	CAS编号	包装	QQ客服
Monomethyl kolavate	CFN98262	24513-41-5	1mg	QQ客服：1457312923
Monomethyl kolavate	CFN98262	24513-41-5	5mg	QQ客服：1457312923
Monomethyl kolavate	CFN98262	24513-41-5	10mg	QQ客服：1457312923
Monomethyl kolavate	CFN98262	24513-41-5	20mg	QQ客服：1457312923

存储与注意事项

1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。

2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。通常，这些可用于长达两周。使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。

3. 需要更多关于溶解度，使用和处理的建议？请发送电子邮件至：service@chemfaces.com

订购流程

1. 在线订购

请联系我们QQ客服

2. 电话订购

请拨打电话：
027-84237683 或 027-84237783

3. 邮件或传真订购

发送电子邮件到: manager@chemfaces.com 或
发送传真到：027-84254680

提供订购信息

为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。

1. 产品编号（CAS No.或产品名称）

2. 发货地址

3. 联系方法 (联系人，电话）

4. 开票抬头 (如果需要发票的客户）

5. 发票地址（发货地址与发票地址不同）

发货时间

1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。

2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。

3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。

ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Florida A&M University (USA)

Centrum Menselijke Erfelijkheid (Belgium)

Heinrich-Heine-University Düsseldorf (Germany)

Medical University of South Carolina (USA)

University of Lodz (Poland)

Mahatma Gandhi University (India)

Rio de Janeiro State University (Brazil)

CSIRO - Agriculture Flagship (Australia)

Monash University (Australia)

VIT University (India)

University of Perugia (Italy)

MTT Agrifood Research Finland (Finland)

University of Toulouse (France)

Indian Institute of Science (India)

More...

Description:

Monomethyl kolavate is a power Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) inhibitor, with an IC50 value of 12uM.

Targets:

Antifection

In vitro:

Molecules. 2015 Sep 3;20(9):16154-69.

In Silico Identification and in Vitro Activity of Novel Natural Inhibitors of Trypanosoma brucei Glyceraldehyde-3-phosphate-dehydrogenase.[Pubmed: 26404225 ]

As part of our ongoing efforts to identify natural products with activity against pathogens causing neglected tropical diseases, we are currently performing an extensive screening of natural product (NP) databases against a multitude of protozoan parasite proteins.
METHODS AND RESULTS:
Within this project, we screened a database of NPs from a commercial supplier, AnalytiCon Discovery (Potsdam, Germany), against Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH), a glycolytic enzyme whose inhibition deprives the parasite of energy supply. NPs acting as potential inhibitors of the mentioned enzyme were identified using a pharmacophore-based virtual screening and subsequent docking of the identified hits into the active site of interest. In a set of 700 structures chosen for the screening, 13 (1.9%) were predicted to possess significant affinity towards the enzyme and were therefore tested in an in vitro enzyme assay using recombinant TbGAPDH. Nine of these in silico hits (69%) showed significant inhibitory activity at 50 µM, of which two geranylated benzophenone derivatives proved to be particularly active with IC50 values below 10 µM.
CONCLUSIONS:
These compounds also showed moderate in vitro activity against T. brucei rhodesiense and may thus represent interesting starting points for further optimization.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
2-Oxokolavelool; 2-Oxokolavelool	CFN97783	221466-41-7	C₂₀H₃₂O₂ = 304.47	5mg	QQ客服：2159513211
克拉维醇; Kolavenol	CFN97792	19941-83-4	C₂₀H₃₄O = 290.49	5mg	QQ客服：3257982914
2-氧代克拉维醇; 2-Oxokolavenol	CFN97832	130395-82-3	C₂₀H₃₂O₂ = 304.47	5mg	QQ客服：2056216494
16-Oxocleroda-3,13E-dien-15-oic acid ; 16-Oxocleroda-3,13E-dien-15-oic acid	CFN96984	117620-72-1	C₂₀H₃₀O₃ = 318.45	5mg	QQ客服：1457312923
Monomethyl kolavate; Monomethyl kolavate	CFN98262	24513-41-5	C₂₁H₃₂O₄ = 348.5	5mg	QQ客服：1457312923
Scutebata E; Scutebata E	CFN99325	1207181-61-0	C₂₈H₄₀O₉ = 520.6	5mg	QQ客服：2056216494
Scutebata F; Scutebata F	CFN99326	1207181-62-1	C₃₀H₃₇NO₉ = 555.6	5mg	QQ客服：2159513211
Scutebata G; Scutebata G	CFN99327	1207181-63-2	C₄₀H₄₁NO₉ = 679.8	5mg	QQ客服：1413575084
6-O-烟酰半枝莲碱 G; 6-O-Nicotinoylscutebarbatine G	CFN96994	1206805-30-2	C₃₂H₃₆N₂O₈ = 576.64	5mg	QQ客服：2056216494
半枝莲碱 W ; Scutebarbatine W	CFN96705	1312716-25-8	C₃₃H₃₇NO₈ = 575.65	5mg	QQ客服：2159513211

信息支持

公司简介
订购流程
付款方式
退换货政策

ChemFaces提供的产品仅用于科学研究使用，不用于诊断或治疗程序。

联系方式

电机：027-84237783
传真：027-84254680
在线QQ: 1413575084
E-Mail：manager@chemfaces.com

湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房

ChemFaces为科学家，科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产。

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.8694 mL	14.3472 mL	28.6944 mL	57.3888 mL	71.736 mL
5 mM	0.5739 mL	2.8694 mL	5.7389 mL	11.4778 mL	14.3472 mL
10 mM	0.2869 mL	1.4347 mL	2.8694 mL	5.7389 mL	7.1736 mL
50 mM	0.0574 mL	0.2869 mL	0.5739 mL	1.1478 mL	1.4347 mL
100 mM	0.0287 mL	0.1435 mL	0.2869 mL	0.5739 mL	0.7174 mL