Monomethyl kolavate

	产品编号	CFN98262
	CAS编号	24513-41-5
	分子式 = 分子量	C₂₁H₃₂O₄ = 348.5
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Diterpenoids
	植物来源	The woods of Gossweilerodendron balsamiferum
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
Monomethyl kolavate	CFN98262	24513-41-5	1mg	QQ客服：1457312923
Monomethyl kolavate	CFN98262	24513-41-5	5mg	QQ客服：1457312923
Monomethyl kolavate	CFN98262	24513-41-5	10mg	QQ客服：1457312923
Monomethyl kolavate	CFN98262	24513-41-5	20mg	QQ客服：1457312923

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Limpopo (South Africa)

Uniwersytet Jagielloński w Krakowie (Poland)

University of Wuerzburg (Germany)

Mahidol University (Thailand)

The Australian National University (Australia)

Wageningen University (Netherlands)

Northeast Normal University Changchun (China)

Universite de Lille1 (France)

Universidade do Porto (Portugal)

Korea Intitute of Science and Technology (KIST) (Korea)

Universidad Miguel Hernández (Spain)

Agricultural Research Organization (ARO) (Israel)

Max Rubner-Institut (MRI) (Germany)

University of Toronto (Canada)

More...

Description:

Monomethyl kolavate is a power Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) inhibitor, with an IC50 value of 12uM.

Targets:

Antifection

In vitro:

Molecules. 2015 Sep 3;20(9):16154-69.

In Silico Identification and in Vitro Activity of Novel Natural Inhibitors of Trypanosoma brucei Glyceraldehyde-3-phosphate-dehydrogenase.[Pubmed: 26404225 ]

As part of our ongoing efforts to identify natural products with activity against pathogens causing neglected tropical diseases, we are currently performing an extensive screening of natural product (NP) databases against a multitude of protozoan parasite proteins.
METHODS AND RESULTS:
Within this project, we screened a database of NPs from a commercial supplier, AnalytiCon Discovery (Potsdam, Germany), against Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH), a glycolytic enzyme whose inhibition deprives the parasite of energy supply. NPs acting as potential inhibitors of the mentioned enzyme were identified using a pharmacophore-based virtual screening and subsequent docking of the identified hits into the active site of interest. In a set of 700 structures chosen for the screening, 13 (1.9%) were predicted to possess significant affinity towards the enzyme and were therefore tested in an in vitro enzyme assay using recombinant TbGAPDH. Nine of these in silico hits (69%) showed significant inhibitory activity at 50 µM, of which two geranylated benzophenone derivatives proved to be particularly active with IC50 values below 10 µM.
CONCLUSIONS:
These compounds also showed moderate in vitro activity against T. brucei rhodesiense and may thus represent interesting starting points for further optimization.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Scutebata F; Scutebata F	CFN99326	1207181-62-1	C₃₀H₃₇NO₉ = 555.6	5mg	QQ客服：1413575084
Scutebata G; Scutebata G	CFN99327	1207181-63-2	C₄₀H₄₁NO₉ = 679.8	5mg	QQ客服：1457312923
6-O-烟酰半枝莲碱 G; 6-O-Nicotinoylscutebarbatine G	CFN96994	1206805-30-2	C₃₂H₃₆N₂O₈ = 576.64	5mg	QQ客服：2159513211
半枝莲碱 W ; Scutebarbatine W	CFN96705	1312716-25-8	C₃₃H₃₇NO₈ = 575.65	5mg	QQ客服：2159513211
2-Oxokolavelool; 2-Oxokolavelool	CFN97783	221466-41-7	C₂₀H₃₂O₂ = 304.47	5mg	QQ客服：1457312923
克拉维醇; Kolavenol	CFN97792	19941-83-4	C₂₀H₃₄O = 290.49	5mg	QQ客服：1413575084
2-氧代克拉维醇; 2-Oxokolavenol	CFN97832	130395-82-3	C₂₀H₃₂O₂ = 304.47	5mg	QQ客服：2159513211
16-Oxocleroda-3,13E-dien-15-oic acid ; 16-Oxocleroda-3,13E-dien-15-oic acid	CFN96984	117620-72-1	C₂₀H₃₀O₃ = 318.45	5mg	QQ客服：215959384
Monomethyl kolavate; Monomethyl kolavate	CFN98262	24513-41-5	C₂₁H₃₂O₄ = 348.5	5mg	QQ客服：2159513211
Scutebata E; Scutebata E	CFN99325	1207181-61-0	C₂₈H₄₀O₉ = 520.6	5mg	QQ客服：2056216494

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.8694 mL	14.3472 mL	28.6944 mL	57.3888 mL	71.736 mL
5 mM	0.5739 mL	2.8694 mL	5.7389 mL	11.4778 mL	14.3472 mL
10 mM	0.2869 mL	1.4347 mL	2.8694 mL	5.7389 mL	7.1736 mL
50 mM	0.0574 mL	0.2869 mL	0.5739 mL	1.1478 mL	1.4347 mL
100 mM	0.0287 mL	0.1435 mL	0.2869 mL	0.5739 mL	0.7174 mL