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  • 脱镁叶绿酸A甲酯

    • 脱镁叶绿酸A甲酯

    Methylpheophorbide A

    脱镁叶绿酸A甲酯
    		产品编号 CFN91976
    CAS编号 5594-30-9
    分子式 = 分子量 C36H38N4O5 = 606.71
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The herbs of Rubia cordifolia
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    脱镁叶绿酸A甲酯 CFN91976 5594-30-9 1mg QQ客服：3257982914
    脱镁叶绿酸A甲酯 CFN91976 5594-30-9 5mg QQ客服：3257982914
    脱镁叶绿酸A甲酯 CFN91976 5594-30-9 10mg QQ客服：3257982914
    脱镁叶绿酸A甲酯 CFN91976 5594-30-9 20mg QQ客服：3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • Universidad de La Salle (Mexico)
  • Universidad Industrial de Santander (Colombia)
  • Monash University Malaysia (Malaysia)
  • Universidade de Franca (Brazil)
  • University of Sao Paulo (Brazil)
  • University of Hertfordshire (United Kingdom)
  • Donald Danforth Plant Science Center (USA)
  • Northeast Normal University Changchun (China)
  • Universite Libre de Bruxelles (Belgium)
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  • Heidelberg University (Germany)
  • Chiang Mai University (Thailand)
  • More...
    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Oncol Rep.2021, 46(2):166.
  • Chem Biol Interact.2019, 315:108910
  • Molecules.2023, 28(8):3414.
  • LWT2020, 130:109535
  • Arch Toxicol.2017, 91(10):3225-3245
  • Anticancer Res.2022, 42(9):4403-4410.
  • Int J Mol Sci.2019, 20(3):E651
  • Nutrients.2018, 11(1):E17
  • Advances in Traditional Medicine 2021, 21:779-789.
  • In Vitro Cellular & Developmental Biology - Plant 2021, 57:874–882.
  • Nature Ecology & Evolution2020, doi: 10.1038
  • Cell.2018, 172(1-2):249-261
  • J Ethnopharmacol.2019, 228:132-141
  • Molecules.2019, 24(4):E744
  • Anat Rec2018, 24264
  • J Traditional Thai Medical Res.2022, 8(1):pp1-14.
  • Int J Mol Sci.2022, 23(23):14826.
  • Nutrients.2020, 12(5):1242.
  • J-STAGE2015, 249-255
  • Molecules2022, 27(9):2992.
  • FEBS Lett.2021, 595(20):2608-2615.
  • J Nat Prod.2017, 80(4):854-863
  • J Ethnopharmacol.2020, 269:113752.
  • ...
    • 生物活性
    Description: Methylphophorbide A shows antioxidative and anticarcinogenic activities.
    In vitro:
    Photodiagnosis Photodyn Ther. 2017 Mar;17:39-47.
    Semi-synthesis and PDT activities of a new amphiphilic chlorin derivative.[Pubmed: 27769913]
    An amphiphilic chlorin derivative (CHL-T) was prepared from Methylpheophorbide A (CHL) and 2-Amino-2-(hydroxymethyl)-1,3-propanediol (TRISMA®).
    METHODS AND RESULTS:
    The new chlorin was compared to other dyes (CHL and Hypericin) in relation to photophysical and photobiological activities in tumor and non-tumor cell lines. Cytotoxicity and cell death target were determined to evaluate the CHL-T efficiency, comparing to the precursor CHL and to the well-known dye hypericin (HY). All of the studied compounds exhibited absorption bands in the therapeutic window and presented a small fluorescence quantum yield compared to the reference dye (rhodamine B). CHL-T was about three times more efficient on singlet oxygen generation than the others photosensitizers. The lipophilicity order of the photosensitizers was CHL>HY>CHL-T. The tumoral HeLa cells presented improved accumulation for CHL and CHL-T compared to HY. The phototoxicity presented by the CHL-T was about ten times higher than by CHL, as demonstrated by the MTT assay. CHL-T showed more cytotoxicity to tumoral cell, comparing to non-tumoral cell in short incubation time. The cell death rises proportionally with increasing PSs concentrations, mainly by necrosis.
    CONCLUSIONS:
    These findings suggest that CHL-T is a potential new photosensitizer for PDT.
    Nat Prod Res. 2016;30(4):474-7.
    Antioxidative and anticarcinogenic activities of methylpheophorbide a, isolated from wheat grass (Triticum aestivum Linn.).[Pubmed: 25782530 ]
    Methylphophorbide A (MPa) has been isolated from the ethanol extract of the wheat grass plant.
    METHODS AND RESULTS:
    Its antioxidative efficacy is evaluated by hydroxyl radical scavenging activities and reducing capacity which are significantly up regulated in comparison with aqueous extract of the plant. The compound shows iron-binding capacity where the Fe(2+) binds with MPa by two types of binding patterns with dissociation constants 157.17 and 27.89. It has antioxidative and cytotoxic effects on HeLa and Hep G2 cells. The cancerous cell survivability decreases with increasing concentration of MPa.
    CONCLUSIONS:
    These findings have provided evidence for the traditional use of the wheat grass plant in the treatment of cancers, oxidative stress and iron overloaded disorders.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6482 mL 8.2412 mL 16.4823 mL 32.9647 mL 41.2058 mL
    5 mM 0.3296 mL 1.6482 mL 3.2965 mL 6.5929 mL 8.2412 mL
    10 mM 0.1648 mL 0.8241 mL 1.6482 mL 3.2965 mL 4.1206 mL
    50 mM 0.033 mL 0.1648 mL 0.3296 mL 0.6593 mL 0.8241 mL
    100 mM 0.0165 mL 0.0824 mL 0.1648 mL 0.3296 mL 0.4121 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    RA VII; RA VII CFN92604 86229-97-2 C41H50N6O9 = 770.9 5mg QQ客服：2159513211
    RA-V; RA-V CFN92605 64725-24-2 C40H48N6O9 = 756.9 5mg QQ客服：1413575084
    RA-XI; RA-XI CFN92606 143277-27-4 C42H50N6O11 = 814.9 5mg QQ客服：1457312923
    恩镰孢菌素B; Enniatin B CFN97902 917-13-5 C33H57N3O9 = 639.8 5mg QQ客服：3257982914
    恩镰孢菌素B1; Enniatin B1 CFN97986 19914-20-6 C34H59N3O9 = 653.9 5mg QQ客服：3257982914
    脱镁叶绿酸A甲酯; Methylpheophorbide A CFN91976 5594-30-9 C36H38N4O5 = 606.71 5mg QQ客服：2159513211
    细胞松驰素D; Cytochalasin D CFN98204 22144-77-0 C30H37NO6 = 507.6 5mg QQ客服：215959384
    细胞松驰素 C; Cytochalasin C CFN70315 22144-76-9 C30H37NO6 = 507.6 5mg QQ客服：1413575084
    细胞松弛素B; Cytochalasin B CFN96781 14930-96-2 C29H37NO5 = 479.61 5mg QQ客服：3257982914

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