芥子酸甲酯

Methyl sinapate

	产品编号	CFN97787
	CAS编号	20733-94-2
	分子式 = 分子量	C₁₂H₁₄O₅ = 238.24
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Phenylpropanoids
	植物来源	The herbs of Rauvolfia tetraphylla
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
芥子酸甲酯	CFN97787	20733-94-2	10mg	QQ客服：215959384
芥子酸甲酯	CFN97787	20733-94-2	20mg	QQ客服：215959384
芥子酸甲酯	CFN97787	20733-94-2	50mg	QQ客服：215959384
芥子酸甲酯	CFN97787	20733-94-2	100mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Maryland (USA)

Universidade Federal de Pernambuco (UFPE) (Brazil)

Anna University (India)

The University of Newcastle (Australia)

Universite de Lille1 (France)

Shanghai Institute of Biochemistry and Cell Biology (China)

National Chung Hsing University (Taiwan)

Tokyo Woman's Christian University (Japan)

University of Medicine and Pharmacy (Romania)

Calcutta University (India)

Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)

Lodz University of Technology (Poland)

Heinrich-Heine-University Düsseldorf (Germany)

Sanford Burnham Prebys Medical Discovery Institute (USA)

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Description:

Methyl sinapate can increase the frequency of cells with chromosome aberrations in the CHO K-1 cells treated with MMC, 4NQO or UV.

In vitro:

Mutat Res. 1989 Jun;212(2):213-21.

Enhancing effects of cinoxate and methyl sinapate on the frequencies of sister-chromatid exchanges and chromosome aberrations in cultured mammalian cells.[Pubmed: 2499777]

METHODS AND RESULTS:
Sister-chromatid exchanges (SCEs) induced by mitomycin C (MMC), 4-nitroquinoline-1-oxide (4NQO) or UV-light in cultured Chinese hamster ovary cells (CHO K-1 cells) were enhanced by cinoxate (2-ethoxyethyl p-methoxycinnamate) or Methyl sinapate (methyl 3,5-dimethoxy 4-hydroxycinnamate). Both substances are cinnamate derivatives and cinoxate is commonly used as a cosmetic UV absorber. Methyl sinapate also increased the frequency of cells with chromosome aberrations in the CHO K-1 cells treated with MMC, 4NQO or UV. These increasing effects of Methyl sinapate were critical in the G1 phase of the cell cycle and the decline of the frequencies of UV-induced SCEs and chromosome aberrations during liquid holding was not seen in the presence of Methyl sinapate. Both compounds were, however, ineffective in cells treated with X-rays. In cells from a normal human embryo and from a xeroderma pigmentosum (XP) patient, MMC-induced SCEs were also increased by the post-treatment with Methyl sinapate. The SCE frequencies in UV-irradiated normal human cells were elevated by Methyl sinapate, but no SCE-enhancing effects were observed in UV-irradiated XP cells.
CONCLUSIONS:
Our results suggest that the test substances inhibit DNA excision repair and that the increase in the amount of unrepaired DNA damage might cause the enhancement of induced SCEs and chromosome aberrations.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
反式-5-羟基阿魏酸; trans-5-Hydroxyferulic acid	CFN70250	110642-42-7	C₁₀H₁₀O₅ = 210.2	5mg	QQ客服：215959384
芥子醇; Sinapyl alcohol	CFN91507	537-33-7	C₁₁H₁₄O₄ = 210.2	20mg	QQ客服：3257982914
反-3,5-二甲氧基-4-羟基肉桂醛; trans-3,5-Dimethoxy-4-hydroxy cinnamaldehyde	CFN70106	4206-58-0	C₁₁H₁₂O₄ = 208.2	20mg	QQ客服：215959384
3,5-二甲氧基-4-羟基肉桂酸，芥子酸; Sinapic acid	CFN92631	530-59-6	C₁₁H₁₂O₅ = 224.2	20mg	QQ客服：215959384
芥子酸甲酯; Methyl sinapate	CFN97787	20733-94-2	C₁₂H₁₄O₅ = 238.24	20mg	QQ客服：1457312923
3,4,5-三甲氧基肉桂酸; 3,4,5-Trimethoxy-trans-cinnamic acid	CFN92506	20329-98-0	C₁₂H₁₄O₅ = 238.2	20mg	QQ客服：1413575084
3,4,5-三甲氧基肉桂酸; 3,4,5-Trimethoxycinnamic acid	CFN98182	90-50-6	C₁₂H₁₄O₅ = 238.24	20mg	QQ客服：1457312923
3,4,5-三甲基肉桂酸甲酯; Methyl 3,4,5-trimethoxycinnamate	CFN97691	7560-49-8	C₁₃H₁₆O₅ = 252.26	20mg	QQ客服：215959384
2,3,4-三甲氧基肉桂酸; trans-2,3,4-Trimethoxycinnamic acid	CFN98189	33130-03-9	C₁₂H₁₄O₅ = 238.24	20mg	QQ客服：3257982914
Secodihydro-hydramicromelin B; Secodihydro-hydramicromelin B	CFN97911	1212148-58-7	C₁₅H₁₈O₈ = 326.3	5mg	QQ客服：2056216494

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.1974 mL	20.9872 mL	41.9745 mL	83.949 mL	104.9362 mL
5 mM	0.8395 mL	4.1974 mL	8.3949 mL	16.7898 mL	20.9872 mL
10 mM	0.4197 mL	2.0987 mL	4.1974 mL	8.3949 mL	10.4936 mL
50 mM	0.0839 mL	0.4197 mL	0.8395 mL	1.679 mL	2.0987 mL
100 mM	0.042 mL	0.2099 mL	0.4197 mL	0.8395 mL	1.0494 mL