| In vitro: |
| International Symposium on Information Technology in Medicine and Education. IEEE, 2012:1000-1003. | | Identification of gallicin from Myricaria laxiflora and its antibiotic & antioxidant activity[Reference: WebLink] | Myricaria Laxiflora is a rare and endangered riparian shrub in Three Gorges zone, China. Locally, the plants are widely used as a traditional herbal medicine for scald and arthritis, but the pharmacological activity has not been elucidated, and the mechanism was far from clear. In order to explore the possible pharmacological mechanism, 6 compounds were extracted here by chloroform in the 95% ethanol precipitation under different pH value.
METHODS AND RESULTS:
After investigation of the antimicrobial activity in vitro through eight microorganisms, we found the compounds in different pH condition showed specific inhibitory activity to bacteria and fungus. In pH=7 extract, we isolated a gallic acid derivant named Methyl 3-hydroxy-4,5-dimethoxybenzoate (gallicin) by 1D, 2D NMR and MS identification, and this compound showed obvious antimicrobial activities.
CONCLUSIONS:
The minimum inhibitory concentration of this compound was 5 mg/ml against Staphylococcus aureus and Rhizopus, and 10 mg/ml against E. coli. Furthermore, just like propyl gallate, gallicin showed fairly active for oxidation resistance in the presence of H2O2. |
|
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)
