蜂蜜曲菌素
Mellein
|
|
产品编号 |
CFN97913 |
| CAS编号 |
480-33-1 |
| 分子式 = 分子量 |
C10H10O3 = 178.2 |
| 产品纯度 |
>=98% |
| 物理属性 |
Powder |
| 化合物类型 |
Coumarins |
| 植物来源 |
The herbs of Goniothalamus griffithii |
| ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 蜂蜜曲菌素 |
CFN97913 |
480-33-1 |
1mg |
QQ客服：2056216494 |
| 蜂蜜曲菌素 |
CFN97913 |
480-33-1 |
5mg |
QQ客服：2056216494 |
| 蜂蜜曲菌素 |
CFN97913 |
480-33-1 |
10mg |
QQ客服：2056216494 |
| 蜂蜜曲菌素 |
CFN97913 |
480-33-1 |
20mg |
QQ客服：2056216494 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
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Warszawski Uniwersytet Medyczny (Poland)
Yale University (USA)
Ain Shams University (Egypt)
University of Toronto (Canada)
FORTH-IMBB (Greece)
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国外学术期刊发表的引用ChemFaces产品的部分文献
| Description: |
Standard reference |
| In vitro: |
| Appl Environ Microbiol. 2015 Jan;81(1):177-86. | | An in planta-expressed polyketide synthase produces (R)-mellein in the wheat pathogen Parastagonospora nodorum.[Pubmed: 25326302 ] | Parastagonospora nodorum is a pathogen of wheat that affects yields globally.
METHODS AND RESULTS:
Previous transcriptional analysis identified a partially reducing polyketide synthase (PR-PKS) gene, SNOG_00477 (SN477), in P. nodorum that is highly upregulated during infection of wheat leaves. Disruption of the corresponding SN477 gene resulted in the loss of production of two compounds, which we identified as (R)-mellein and (R)-O-methylmellein. Using a Saccharomyces cerevisiae yeast heterologous expression system, we successfully demonstrated that SN477 is the only enzyme required for the production of (R)-mellein. This is the first identification of a fungal PKS that is responsible for the synthesis of (R)-mellein. The P. nodorum ΔSN477 mutant did not show any significant difference from the wild-type strain in its virulence against wheat. However, (R)-mellein at 200 μg/ml inhibited the germination of wheat (Triticum aestivum) and barrel medic (Medicago truncatula) seeds. Comparative sequence analysis identified the presence of mellein synthase (MLNS) homologues in several Dothideomycetes and two sodariomycete genera.
CONCLUSIONS:
Phylogenetic analysis suggests that the MLNSs in fungi and bacteria evolved convergently from fungal and bacterial 6-methylsalicylic acid synthases. | | J Am Chem Soc. 2012 Jul 25;134(29):11924-7. | | Synthesis of (R)-mellein by a partially reducing iterative polyketide synthase.[Pubmed: 22793256] | Disruption of the corresponding SN477 gene resulted in the loss of production of two compounds, which we identified as (R)-Mellein and (R)-O-methylMellein.
METHODS AND RESULTS:
Using a Saccharomyces cerevisiae yeast heterologous expression system, we successfully demonstrated that SN477 is the only enzyme required for the production of (R)-Mellein. This is the first identification of a fungal PKS that is responsible for the synthesis of (R)-Mellein. The P. nodorum ΔSN477 mutant did not show any significant difference from the wild-type strain in its virulence against wheat. However, (R)-Mellein at 200 μg/ml inhibited the germination of wheat (Triticum aestivum) and barrel medic (Medicago truncatula) seeds. Comparative sequence analysis identified the presence of Mellein synthase (MLNS) homologues in several Dothideomycetes and two sodariomycete genera.
CONCLUSIONS:
Phylogenetic analysis suggests that the MLNSs in fungi and bacteria evolved convergently from fungal and bacterial 6-methylsalicylic acid synthases. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
5.6117 mL |
28.0584 mL |
56.1167 mL |
112.2334 mL |
140.2918 mL |
| 5 mM |
1.1223 mL |
5.6117 mL |
11.2233 mL |
22.4467 mL |
28.0584 mL |
| 10 mM |
0.5612 mL |
2.8058 mL |
5.6117 mL |
11.2233 mL |
14.0292 mL |
| 50 mM |
0.1122 mL |
0.5612 mL |
1.1223 mL |
2.2447 mL |
2.8058 mL |
| 100 mM |
0.0561 mL |
0.2806 mL |
0.5612 mL |
1.1223 mL |
1.4029 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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