| In vitro: |
| Journal of the Science of Food and Agriculture, 2019,99(3):1405-1412. | | Two macamide extracts relieve physical fatigue by attenuating muscle damage in mice.[Reference: WebLink] | Macamides, the main active component contained in maca, have attracted increasing attention due to their various bioactivities.
METHODS AND RESULTS:
In this study, crude macamides extract (CME) and purified macamides extract (PME) were prepared by enzyme‐assisted extraction and macroporous resin separation, and anti‐fatigue effects of CME and PME were evaluated in a forced swimming model. The composition analysis results revealed that both CME and PME mainly contain 8 kinds of macamides. Based on the results of weight‐loaded forced swimming test, compared with control group, CME and and PME groups could prolong the exhaustive swimming time, increase the levels of liver glycogen (LG) and muscle glycogen (MG), accelerate the fatty acids oxidation in serum to provide energy, eliminate the accumulation of blood lactic acid (BLA) and blood urea nitrogen (BUN), as well as decrease the serum biomarkers for muscle damage, such as lactate dehydrogenase (LDH) and creatine kinase (CK). In addition, histological analysis indicated that CME and PME attenuated damage of skeletal muscle and myocardium in mice during exercise.
CONCLUSIONS:
Two macamides extracts have a beneficial effect on relieving physical fatigue by attenuating the damage of skeletal muscle and myocardium during exercise, and a better effect was observed in PME group. |
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