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  • 叶黄素

    Lutein

    叶黄素
    产品编号 CFN99384
    CAS编号 127-40-2
    分子式 = 分子量 C40H56O2 = 568.9
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Tetraterpenoids
    植物来源 The herbs of Tagetes erecta
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    叶黄素 CFN99384 127-40-2 10mg QQ客服:215959384
    叶黄素 CFN99384 127-40-2 20mg QQ客服:215959384
    叶黄素 CFN99384 127-40-2 50mg QQ客服:215959384
    叶黄素 CFN99384 127-40-2 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Biotech R&D Institute (USA)
  • Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)
  • Universit?t Basel (Switzerland)
  • Kyung Hee University (Korea)
  • University of Canterbury (New Zealand)
  • Universidad Miguel Hernández (Spain)
  • Gyeongsang National University (Korea)
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • University of Lodz (Poland)
  • Tohoku University (Japan)
  • Charles University in Prague (Czech Republic)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • University of Liège (Belgium)
  • Cornell University (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Res Int.2022, 157:111207.
  • Plant Cell Physiol.2018, 59(1):128-141
  • Vojnosanit Pregl2016, 75(00):391-391
  • Phytomedicine.2021, 93:153796.
  • Phytochemistry.2017, 141:162-170
  • Phytomedicine.2021, 83:153483.
  • Evid Based Complement Alternat Med.2017, 2017:7383104
  • Biol Pharm Bull.2018, 41(1):65-72
  • Journal of Apicultural Research2021, 60(1)
  • Molecules.2023, 28(3):958.
  • Phytother Res.2022, 35844057.
  • Vietnam Journal of Science2022,64(2):69-75.
  • J Integr Plant Biol.2023, 13564.
  • Phytother Res.2022, ptr.7573.
  • Chemistry of Vegetable Raw Materials2019, 3:119-127
  • Carbohydrate Polymer Technologies & App.2021, 2:100049.
  • Int J Med Sci.2020, 17(5):626-631
  • Front Microbiol.2022, 12:833233.
  • Life (Basel).2021, 11(7):616.
  • Natural Product Communications2020, doi: 10.1177.
  • Am J Chin Med.2023, 51(4):1019-1039.
  • Front Plant Sci.2022, 12:811166.
  • Food Sci Biotechnol.2023, 32(9):1215-1223.
  • ...
  • 生物活性
    Description: Lutein and lycopene has chemopreventive activity, the possible mechanism is their antioxidant effects. Nutritional supplementation with lutein or lutein together with antioxidants, vitamins, and minerals, improves visual function and symptoms in atrophic age-related macular degeneration (ARMD).
    Targets: ROS
    In vitro:
    J Chromatogr A. 2015 Apr 3;1388:119-25.
    Isolation of β-carotene, α-carotene and lutein from carrots by countercurrent chromatography with the solvent system modifier benzotrifluoride.[Pubmed: 25728658]
    A carotenoid purification method with dual-mode countercurrent chromatography (CCC) for β-carotene, α-carotene and Lutein from a fresh carrot extract was developed.
    METHODS AND RESULTS:
    The fluorinated liquid benzotrifluoride (IUPAC name: (trifluoromethyl)benzene) was used as a novel modifier in the non-aqueous ternary solvent system n-hexane/benzotrifluoride/acetonitrile. The ternary phase diagram of the type I solvent system was used to select two-phase solvent mixtures which enabled an efficient preparative separation of α-carotene, β-carotene and Lutein from concomitant pigments in crude carrot extract. By means of the modifier, high separation factors (α ≥ 1.2) were obtained, allowing baseline resolution between α-carotene and β-carotene due to specific chemical interactions such as π-π molecular interactions.
    CONCLUSIONS:
    After optimizing the injection step with a pseudo-ternary phase diagram, 51 mg of β-carotene, 32 mg of α-carotene and 4 mg of Lutein could be isolated from 100.2mg crude carrot extract in a short time and with high purities of 95% and 99% by using dual-mode CCC, respectively. Temperatures > 22°C had a negative impact on the separation of α-carotene and β-carotene.
    J Cell Biochem Suppl. 1995;22:236-46.
    Lutein, lycopene, and their oxidative metabolites in chemoprevention of cancer.[Pubmed: 8538204]
    Numerous epidemiological studies have demonstrated that consuming large quantities of fruits and vegetables reduces the risk for several types of human cancers. Carotenoids are abundant in fruits and vegetables and have been extensively studied as cancer preventive agents.
    METHODS AND RESULTS:
    A proposed mechanism of action for the protective effect of carotenoids against cancer is based on their antioxidant capability. Recently, we have isolated and characterized 14 new carotenoids, including seven metabolites from the extracts of human serum/plasma. This brings the total number of identified blood carotenoids to 21. Lutein and lycopene, abundant in most fruits and vegetables as well as human serum, have been shown to possess strong antioxidant capability. Among the metabolites of lutein, four results from oxidation and two from non-enzymatic dehydration. The metabolite of lycopene has been identified as 5,6-dihydroxy-5,6-dihydrolycopene, which apparently results from oxidation of lycopene to an intermediate, lycopene epoxide. This intermediate may undergo metabolic reduction to form the lycopene metabolite. Although in vivo oxidation of lutein to its metabolites has been demonstrated based on data obtained from two human studies, in vivo oxidation of lycopene to its metabolite has not yet been established.
    CONCLUSIONS:
    Recent preliminary studies involving healthy subjects ingesting purified lutein and zeaxanthin (a dietary dihydroxycarotenoid isomeric to lutein) are presented. We propose a possible antioxidant mechanism of action for lutein and lycopene that leads to formation of the oxidation products of these promising chemopreventive agents.
    In vivo:
    Int J Food Sci Nutr. 2014 Nov;65(7):903-9.
    Bioavailability of lutein from a lutein-enriched egg-yolk beverage and its dried re-suspended versions.[Pubmed: 25017577]
    Drying a fresh Lutein-enriched egg-yolk beverage would extend its shelf life, however, functional properties should not be affected. It was investigated whether consumption of a dried beverage containing Lutein-enriched egg-yolk significantly increases serum Lutein.
    METHODS AND RESULTS:
    One-hundred healthy young subjects participated in this 6-weeks randomized controlled study. Subjects consumed either a "plain" control beverage (n = 26), a fresh Lutein-enriched egg-yolk beverage (n = 25), a dried version of this beverage (n = 25), or a beverage composed of the dried individual components of the drink (n = 24). The fresh and both dried versions of the Lutein-enriched egg-yolk beverage were able to increase serum Lutein levels after 6 weeks of consumption (Lutein change: -38 ± 47 nmol/L, +304 ± 113 nmol/L, +148 ± 79 nmol/L and +178 ± 83 nmol/L for control, fresh, dried and combined dried group respectively; p < 0.001). No significant change in serum cholesterol level was seen in the beverages containing Lutein-enriched egg-yolk compared to the control drink.
    Nutr Rev. 2014 Sep;72(9):605-12.
    Role of lutein and zeaxanthin in visual and cognitive function throughout the lifespan.[Pubmed: 25109868]
    The relationship between Lutein and zeaxanthin and visual and cognitive health throughout the lifespan is compelling.
    METHODS AND RESULTS:
    There is a variety of evidence to support a role for Lutein and zeaxanthin in vision. Lutein's role in cognition has only recently been considered. Lutein and its isomer, zeaxanthin, are taken up selectively into eye tissue. Lutein is the predominant carotenoid in human brain tissue. Lutein and zeaxanthin in neural tissue may have biological effects that include antioxidation, anti-inflammation, and structural actions. In addition, Lutein and zeaxanthin may be protective against eye disease because they absorb damaging blue light that enters the eye. In pediatric brains, the relative contribution of Lutein to the total carotenoids is twice that found in adults, accounting for more than half the concentration of total carotenoids.
    CONCLUSIONS:
    The greater proportion of Lutein in the pediatric brain suggests a need for Lutein during neural development as well. In adults, higher Lutein status is related to better cognitive performance, and Lutein supplementation improves cognition. The evidence to date warrants further investigation into the role of Lutein and zeaxanthin in visual and cognitive health throughout the lifespan.
    Invest Ophthalmol Vis Sci. 2014 Jul 29;55(8):5238-44.
    Effects of a lutein supplement on the plasma lutein concentration and macular pigment in patients with central serous chorioretinopathy.[Pubmed: 25074771]
    To investigate the effects of Lutein supplementation on plasma Lutein concentrations and the macular pigment optical density (MPOD) in central serous chorioretinopathy (CSC).
    METHODS AND RESULTS:
    In this double-masked placebo-controlled study, 20 patients received Lutein 20 mg/d and 19 received placebo. The plasma Lutein concentration and MPOD using autofluorescence spectrometry (density unit, DU) were measured at baseline and 1 and 4 months. RESULTS: The mean plasma Lutein concentrations and MPOD values in the Lutein and control groups, respectively, were 91.5 and 78.2 ng/mL and 0.444 and 0.437 DU at baseline; 204.9 and 79.3 ng/mL and 0.460 and 0.442 DU at 1 month; and 228.0 and 78.4 ng/mL and 0.441 and 0.421 DU at 4 months. The plasma concentration in the Lutein group was significantly higher than in controls at 1 and 4 months (P < 0.0001 for both comparisons); however, the MPOD values did not differ significantly between groups at 1 (P = 0.479) or 4 months (P = 0.883). In patients with a plasma Lutein concentration below the mean level in 20 age-matched healthy subjects (mean 105.3 ng/mL; n = 13 in Lutein group, n = 15 in control group), the control MPOD values significantly (P = 0.0430) decreased at 4 months (mean baseline, 0.437 DU; 4 months, 0.404 DU). The MPOD in the Lutein group remained at the baseline level (mean baseline, 0.426 DU; 4 months, 0.438 DU) (P = 0.6542).
    CONCLUSIONS:
    The MPOD did not increase in patients with CSC with short-term Lutein supplementation; however, among patients with low plasma Lutein, supplemental Lutein prevented a decline in MPOD that was observed in control subjects.
    Int J Biochem Cell Biol . 2021 Apr;133:105932.
    Lutein attenuates excessive lipid accumulation in differentiated 3T3-L1 cells and abdominal adipose tissue of rats by the SIRT1-mediated pathway[Pubmed: 33529717]
    Abstract Objective: Obesity is now a worldwide disease and is mainly attributable to increased body fat deposition. In a growing number of epidemiological studies, lutein has been revealed to have different degrees of anti-obesity properties, but the potential underlying mechanisms that have been reported are limited. Therefore, we aimed to clarify the protective effects of lutein against excessive lipid accumulation, and we explored the role of SIRT1 and SIRT1-mediated pathways both in abdominal adipose tissue and mature 3T3-L1 cells during lutein administration. Methods: In our design, male Sprague-Dawley rats were fed either control or high-fat diets with or without 25 mg/kg·bw/day lutein for 5 weeks. Additionally, differentiated 3T3-L1 cells were incubated with 40 μM lutein or 10 μM Ex527 for 24 h. Results: Lutein supplementation decreased the body weight, abdominal fat index ratio, frequency and mean area of larger adipocytes in HE staining induced by the high-fat diet and then activated the expression of SIRT1 and thus upregulated FoxO1, ATGL, and HSL expression and downregulated SREBP-1, FAS, and ACC expression both in abdominal adipose tissue and differentiated 3T3-L1 cells. However, coincubation with Ex527 and lutein suppressed the activation of SIRT1 and reversed the expression of FoxO1, ATGL, HSL, SREBP-1, FAS, and ACC in comparison to those in the Lut group. Conclusions: Overall, we suggest that the effects of lutein on attenuating excessive lipid accumulation are dependent on the SIRT1-mediated pathway in vivo and in vitro, which indicates that lutein administration may be a potential strategy for preventing excessive lipid accumulation and obesity.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.7578 mL 8.7889 mL 17.5778 mL 35.1556 mL 43.9445 mL
    5 mM 0.3516 mL 1.7578 mL 3.5156 mL 7.0311 mL 8.7889 mL
    10 mM 0.1758 mL 0.8789 mL 1.7578 mL 3.5156 mL 4.3944 mL
    50 mM 0.0352 mL 0.1758 mL 0.3516 mL 0.7031 mL 0.8789 mL
    100 mM 0.0176 mL 0.0879 mL 0.1758 mL 0.3516 mL 0.4394 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    β-隐黄素; beta-Cryptoxanthin CFN70370 472-70-8 C40H56O = 552.9 5mg QQ客服:3257982914
    辣椒红; Capsanthin CFN70366 465-42-9 C40H56O3 = 584.9 5mg QQ客服:2056216494
    虾青素; Astaxanthin CFN90096 472-61-7 C40H52O4 = 596.85 20mg QQ客服:3257982914
    叶黄素; Lutein CFN99384 127-40-2 C40H56O2 = 568.9 20mg QQ客服:1457312923
    土木香素; Helenien CFN70406 547-17-1 C72H116O4 = 1045.7 5mg QQ客服:3257982914
    玉米黄质; Zeaxanthin CFN90234 144-68-3 C40H56O2 = 568.88 5mg QQ客服:1457312923
    酸浆果红素; Physalien CFN70273 144-67-2 C72H116O4 = 1045.7 5mg QQ客服:215959384
    α-胡萝卜素; alpha-Carotene CFN93610 7488-99-5 C40H56 = 536.87 5mg QQ客服:215959384
    β-胡萝卜素; Beta-Carotene CFN98117 7235-40-7 C40H56 = 536.88 20mg QQ客服:215959384
    岩藻黄质; Fucoxanthin CFN90852 3351-86-8 C42H58O6 = 658.9 20mg QQ客服:215959384

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