羽扇豆醇

Lupeol

	产品编号	CFN98913
	CAS编号	545-47-1
	分子式 = 分子量	C₃₀H₅₀O = 426.7
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The flower of Chrysanthemum morifolium
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
羽扇豆醇	CFN98913	545-47-1	10mg	QQ客服：215959384
羽扇豆醇	CFN98913	545-47-1	20mg	QQ客服：215959384
羽扇豆醇	CFN98913	545-47-1	50mg	QQ客服：215959384
羽扇豆醇	CFN98913	545-47-1	100mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Description:

1. Lupeol has a potential to act as an anti-inflammatory, anti-microbial, anti-protozoal, anti-proliferative, anti-invasive, anti-angiogenic, antimalarial and cholesterol lowering agent.
2. Lupeol prevents acetaminophen-induced in vivo hepatotoxicity by altering the Bax/Bcl-2 and oxidative stress-mediated mitochondrial signaling cascade.
3. Lupeol and its ester derivative have beneficial effects on hypercholesterolemia-induced oxidative and inflammatory stresses.
4. Lupeol significantly enhances the radiosensitivity of SMMC-7721 cells in vitro and in vivo.
5. Lupeol shows antidiabetic and antioxidant potential in experimental hyperglycaemia.
6. Lupeol has potential anticancer effect against hepatocellular and pancreatic cancer, by inhibiting cell proliferation, inducing apoptosis and blocking Akt/PI3K and Wnt signaling pathway.
7. Lupeol has antiangiogenic effects, it (at 50 and 30 microg/mL) shows a marked inhibitory activity on human umbilical venous endothelial cells (HUVEC) tube formation while it does not affect the growth of tumor cell lines such as SK-MEL-2, A549, and B16-F10 melanoma.

Targets:

In vitro:

Clin Cancer Res . 2011 Aug 15;17(16):5379-91.

Lupeol, a novel androgen receptor inhibitor: implications in prostate cancer therapy[Pubmed: 21712449]

Abstract Purpose: Conventional therapies to treat prostate cancer (CaP) of androgen-dependent phenotype (ADPC) and castration-resistant phenotype (CRPC) are deficient in outcome which has necessitated a need to identify those agents that could target AR for both disease types. We provide mechanism-based evidence that lupeol (Lup-20(29)-en-3b-ol) is a potent inhibitor of androgen receptor (AR) in vitro and in vivo. Experimental design: Normal prostate epithelial cell (RWPE-1), LAPC4 (wild functional AR/ADPC), LNCaP (mutant functional/AR/ADPC), and C4-2b (mutant functional/AR/CRPC) cells were used to test the anti-AR activity of lupeol. Cells grown under androgen-rich environment and treated with lupeol were tested for proliferation, AR transcriptional activity, AR competitive ligand binding, AR-DNA binding, and AR-ARE/target gene binding. Furthermore, in silico molecular modeling for lupeol-AR binding was done. Athymic mice bearing C4-2b and LNCaP cell-originated tumors were treated intraperitoneally with lupeol (40 mg/kg; 3 times/wk) and tumor growth and surrogate biomarkers were evaluated. To assess bioavailability, lupeol serum levels were measured. Results: Lupeol significantly inhibited R1881 (androgen analogue) induced (i) transcriptional activity of AR and (ii) expression of PSA. Lupeol (i) competed antagonistically with androgen for AR, (ii) blocked the binding of AR to AR-responsive genes including PSA, TIPARP, SGK, and IL-6, and (iii) inhibited the recruitment of RNA Pol II to target genes. Lupeol sensitized CRPC cells to antihormone therapy. High-performance liquid chromatography analysis showed that lupeol is bioavailable to mice. Lupeol inhibited the tumorigenicity of both ADPC and CRPC cells in animals. Serum and tumor tissues exhibited reduced PSA levels. Conclusion: Lupeol, an effective AR inhibitor, could be developed as a potential agent to treat human CaP.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Adiantulupanone; Adiantulupanone	CFN89066	51511-05-8	C₂₉H₄₈O = 412.70	5mg	QQ客服：2159513211
3beta-羟基-30-去甲羽扇烷; 29-Nor-20-oxolupeol	CFN96388	19891-85-1	C₂₉H₄₈O₂ = 428.7	5mg	QQ客服：1413575084
(3beta)-3-羟基羽扇-20(30)-烯-29-醛; 30-Oxolupeol	CFN96383	64181-07-3	C₃₀H₄₈O₂ = 440.7	5mg	QQ客服：1457312923
算盘子酮醇; Glochidonol	CFN98248	23963-54-4	C₃₀H₄₈O₂ = 440.7	5mg	QQ客服：1457312923
算盘子酮; Glochidone	CFN97127	6610-55-5	C₃₀H₄₆O = 422.7	5mg	QQ客服：2159513211
羽扇烯酮; Lupenone	CFN99681	1617-70-5	C₃₀H₄₈O = 424.7	20mg	QQ客服：2159513211
羽扇-20(29)-烯-3bate,23-二醇; Lup-20(29)-ene-3bate,23-diol	CFN96184	163060-07-9	C₃₀H₅₀O₂ = 442.7	5mg	QQ客服：2159513211
Lupeolic acid; Lupeolic acid	CFN96255	87355-32-6	C₃₀H₄₈O₃ = 456.7	5mg	QQ客服：1413575084
羽扇豆醇 3-乙酸酯 ; Lupeol acetate	CFN96583	1617-68-1	C₃₂H₅₂O₂ = 468.77	10mg	QQ客服：1413575084
咖啡酸羽扇豆醇酯; Lupeol caffeate	CFN99057	103917-26-6	C₃₉H₅₆O₄ = 588.9	5mg	QQ客服：1457312923

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.3436 mL	11.7178 mL	23.4357 mL	46.8713 mL	58.5892 mL
5 mM	0.4687 mL	2.3436 mL	4.6871 mL	9.3743 mL	11.7178 mL
10 mM	0.2344 mL	1.1718 mL	2.3436 mL	4.6871 mL	5.8589 mL
50 mM	0.0469 mL	0.2344 mL	0.4687 mL	0.9374 mL	1.1718 mL
100 mM	0.0234 mL	0.1172 mL	0.2344 mL	0.4687 mL	0.5859 mL

羽扇豆醇

Lupeol

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