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  • 赤芝酮

    Lucidone

    赤芝酮
    产品编号 CFN98011
    CAS编号 19956-53-7
    分子式 = 分子量 C15H12O4 = 256.3
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Chalcones
    植物来源 The roots of Lindera strychnifolia
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    赤芝酮 CFN98011 19956-53-7 1mg QQ客服:215959384
    赤芝酮 CFN98011 19956-53-7 5mg QQ客服:215959384
    赤芝酮 CFN98011 19956-53-7 10mg QQ客服:215959384
    赤芝酮 CFN98011 19956-53-7 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidade do Porto (Portugal)
  • Macau University of Science and Technology (China)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Korea Food Research Institute(KFRI) (Korea)
  • Northeast Normal University Changchun (China)
  • University of Stirling (United Kingdom)
  • University of Limpopo (South Africa)
  • University of Wuerzburg (Germany)
  • University of Illinois (USA)
  • Universiti Sains Malaysia (Malaysia)
  • National Research Council of Canada (Canada)
  • University of Wollongong (Australia)
  • Shanghai University of TCM (China)
  • Tokyo Woman's Christian University (Japan)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2022, 27(21):7643.
  • Exp Biol Med (Maywood).2019, 244(18):1665-1679
  • Food Funct.2022, 13(13):6923-6933.
  • Biol Pharm Bull.2018, 41(1):65-72
  • Int J Anal Chem.2017, 2017:1254721
  • Phytomedicine.2022, 100:154036.
  • Chem Pharm Bull (Tokyo).2017, 65(9):826-832
  • LWT-Food Science and Technology2017, 75:488-496
  • European Journal of Integrative Medicine2018, 20:165-172
  • Sci Rep.2019, 9:12132
  • Evid Based Complement Alternat Med.2020, 2020:9416962.
  • Chemistry of Plant Raw Materials2019, 4:135-147
  • J Pain Res.2022, 15:3469-3478.
  • J Sep Sci.2018, 41(7):1682-1690
  • J. of The Korean Society of Food Culture2017, 144-149
  • Oncotarget.2017, 8(53):90925-90947
  • Clin Exp Pharmacol Physiol.2020, doi: 10.1111
  • Nutrients.2020, 12(12):3638.
  • J Cell Mol Med.2023, jcmm.18071.
  • Plant Physiol Biochem.2023, 203:108073.
  • Biomed Chromatogr.2019, 8:e4774
  • Molecules.2021, 26(9):2765.
  • Pak J Pharm Sci.2023, 36(1):51-57.
  • ...
  • 生物活性
    Description: Lucidone possesses hepatoprotective, antioxidant and anti-inflammatory properties, it-mediated up-regulation of phase-II enzymes and HO-1 via Nrf-2 signaling pathway may provide a pivotal mechanism for its hepatoprotective action. Dietary intake of lucidone alleviates high fat diet-induced obesity in C57BL/6 mice and reveals the potential of lucidone as a nutraceutical to prevent obesity and consequent metabolic disorders. Lucidone accelerates wound healing through the cooperation of keratinocyte/fibroblast/ ndothelial cell growth and migration and macrophage inflammation via PI3K/AKT, Wnt/β-catenin and NF-κB signaling cascade activation. Lucidone also suppresses hepatitis C virus replication by Nrf2-mediated heme oxygenase-1 induction, it could be a potential lead or supplement for the development of new anti-HCV agent in the future.
    Targets: ROS | DNA/RNA Synthesis | Nrf2 | PGE | COX | NF-kB | IkB | ERK | p38MAPK | HCV | PPAR | AP-1 | GLUT | NO | TNF-α | HO-1 | TNF-α | NOS | JNK | Wnt/β-catenin | GSK-3 | CDK | p21 | MMP(e.g.TIMP) | PI3K | VEGFR | Akt | IKK
    In vitro:
    Antimicrob Agents Chemother. 2013 Mar;57(3):1180-91.
    Lucidone suppresses hepatitis C virus replication by Nrf2-mediated heme oxygenase-1 induction.[Pubmed: 23254429]

    METHODS AND RESULTS:
    Upon screening of plant-derived natural products against hepatitis C virus (HCV) in the replicon system, we demonstrate that Lucidone, a phytocompound, isolated from the fruits of Lindera erythrocarpa Makino, significantly suppressed HCV RNA levels with 50% effective concentrations of 15 ± 0.5 μM and 20 ± 1.1 μM in HCV replicon and JFH-1 infectious assays, respectively. There was no significant cytotoxicity observed at high concentrations, with a 50% cytotoxic concentration of 620 ± 5 μM. In addition, Lucidone significantly induced heme oxygenase-1 (HO-1) production and led to the increase of its product biliverdin for inducing antiviral interferon response and inhibiting HCV NS3/4A protease activity. Conversely, the anti-HCV activity of Lucidone was abrogated by blocking HO-1 activity or silencing gene expression of HO-1 or NF-E2-related factor 2 (Nrf2) in the presence of Lucidone, indicating that the anti-HCV action of Lucidone was due to the stimulation of Nrf-2-mediated HO-1 expression. Moreover, the combination of Lucidone and alpha interferon, the protease inhibitor telaprevir, the NS5A inhibitor BMS-790052, or the NS5B polymerase inhibitor PSI-7977, synergistically suppressed HCV RNA replication.
    CONCLUSIONS:
    These findings suggest that Lucidone could be a potential lead or supplement for the development of new anti-HCV agent in the future.
    Toxicol In Vitro. 2012 Aug;26(5):700-8.
    Hepatoprotective effect of lucidone against alcohol-induced oxidative stress in human hepatic HepG2 cells through the up-regulation of HO-1/Nrf-2 antioxidant genes.[Pubmed: 22484158 ]
    Lucidone was previously reported to exhibit anti-inflammatory activity in vitro and in vivo.
    METHODS AND RESULTS:
    In the present study, we characterized the mechanisms underlying the hepatoprotective effect of Lucidone against alcohol-induced oxidative stress in vitro. Human hepatoma (HepG2) cells were pretreated with Lucidone (1-10μg/mL) and then hepatotoxicity was stimulated by the addition ethanol (100mM). With response to ethanol-challenge, increased amount of alanine aminotransferase (ALT) and aspirate aminotransferase (AST) release were observed, whereas Lucidone pretreatment significantly inhibited the leakage of AST and ALT in HepG2 cells without appreciable cytotoxic effects. We also found that Lucidone pretreatment significantly decreased ethanol-induced nitric oxide (NO), tumor necrosis factor-α (TNF-α), malondialdehyde (MDA), reactive oxygen species (ROS) and glutathione (GSH) depletion in HepG2 cells. Furthermore, Western blot and quantitative-PCR analyses showed that ethanol-exposure apparently down-regulated endogenous anti-oxidant hemoxygenase-1 (HO-1) expression, whereas pretreatment with Lucidone significantly up-regulates HO-1 expression followed by the transcriptional activation of NF-E2 related factor-2 (Nrf-2). Interestingly, the profound up-regulation of HO-1 and Nrf-2 were observed in only ethanol-challenged cells, which evidenced that Lucidone-induced induction of HO-/Nrf-2 were specific with oxidative stress.
    CONCLUSIONS:
    Thus, we concluded that Lucidone-mediated up-regulation of phase-II enzymes and HO-1 via Nrf-2 signaling pathway may provide a pivotal mechanism for its hepatoprotective action.
    In vivo:
    Int Immunopharmacol. 2010 Apr;10(4):385-92.
    Anti-inflammatory effect of lucidone in mice via inhibition of NF-kappaB/MAP kinase pathway.[Pubmed: 20079881]

    METHODS AND RESULTS:
    Here, we investigated the anti-inflammatory activity of Lucidone, a phytocompound isolated from the fruits of Lindera erythrocarpa Makino, against lipopolysaccharide (LPS)-induced acute systemic inflammation in mice. Male ICR mice were injected intraperitoneally with LPS (5 microg/kg), and the effects of pretreatment with various concentrations of Lucidone (50-200 mg/kg) for 12h on the formation of nitric oxide (NO), prostaglandin-E(2) (PGE(2)) and tumor necrosis factor (TNF-alpha) were analyzed. Lucidone inhibited the production of NO, PGE(2) and TNF-alpha production in LPS-induced mice, and also induced mRNA and protein levels of inducible nitric oxide synthase (iNOS), and cyclooxigenase-2 (COX-2). The two common response elements of the iNOS and COX-2 genes are nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1). NF-kappaB nuclear translocation and DNA binding were inhibited by Lucidone in the LPS-induced mice. Moreover, Lucidone decreased the expression and phosphorylation of c-Jun N-terminal kinase (JNK) protein thereby causing the subsequent inhibition of AP-1 activity. Finally, our results indicated that Lucidone was able to block mitogen-activated protein kinases activity and its downstream signaling activation of NF-kappaB and AP-1.
    CONCLUSIONS:
    We thus conclude that Lucidone exerts its anti-inflammatory effects in mice by inhibiting the expression of pro-inflammatory factors and their related signaling pathways.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.9017 mL 19.5084 mL 39.0168 mL 78.0336 mL 97.5419 mL
    5 mM 0.7803 mL 3.9017 mL 7.8034 mL 15.6067 mL 19.5084 mL
    10 mM 0.3902 mL 1.9508 mL 3.9017 mL 7.8034 mL 9.7542 mL
    50 mM 0.078 mL 0.3902 mL 0.7803 mL 1.5607 mL 1.9508 mL
    100 mM 0.039 mL 0.1951 mL 0.3902 mL 0.7803 mL 0.9754 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    赤芝酮; Lucidone CFN98011 19956-53-7 C15H12O4 = 256.3 5mg QQ客服:215959384
    甲基赤芝萜酮; Methyllucidone CFN98012 19956-54-8 C16H14O4 = 270.3 5mg QQ客服:215959384
    乙基赤芝酮; Ethyllucidone CFN99308 1195233-59-0 C17H16O4 = 284.3 5mg QQ客服:1457312923
    乌药环戊烯二酮; Linderone CFN99837 1782-79-2 C16H14O5 = 286.3 5mg QQ客服:1413575084
    乌药环戊烯二酮甲醚; Methyllinderone CFN98631 3984-73-4 C17H16O5 = 300.3 5mg QQ客服:215959384

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