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  • 异甘草素-葡萄糖芹菜糖苷

    Licraside

    异甘草素-葡萄糖芹菜糖苷
    产品编号 CFN91792
    CAS编号 29913-71-1
    分子式 = 分子量 C26H30O13 = 550.51
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Chalcones
    植物来源 The roots of Glycyrrhiza uralensis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异甘草素-葡萄糖芹菜糖苷 CFN91792 29913-71-1 1mg QQ客服:1457312923
    异甘草素-葡萄糖芹菜糖苷 CFN91792 29913-71-1 5mg QQ客服:1457312923
    异甘草素-葡萄糖芹菜糖苷 CFN91792 29913-71-1 10mg QQ客服:1457312923
    异甘草素-葡萄糖芹菜糖苷 CFN91792 29913-71-1 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Helsinki (Finland)
  • University of South Australia (Australia)
  • University of British Columbia (Canada)
  • University of Auckland (New Zealand)
  • Sri Ramachandra University (India)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • Macau University of Science and Technology (China)
  • CSIRO - Agriculture Flagship (Australia)
  • Universit?t Basel (Switzerland)
  • University of Mysore (India)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • Lodz University of Technology (Poland)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • Washington State University (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Enzyme and Microbial Technology2022, 110002.
  • Int J Mol Sci.2021, 22(12):6466.
  • Pharm Biol.2021, 59(1):134-145.
  • Yakugaku Zasshi.2018, 138(4):571-579
  • Natural Product Communications2020, doi: 10.1177.
  • Int J Mol Sci.2023, 24(3):2102.
  • Molecules.2016, 21(6)
  • Cell.2018, 172(1-2):249-261
  • SBRAS2016, 12
  • Mol Neurobiol.2021, 58(8):3665-3676.
  • Wageningen University & Research2018, January 2018
  • Int J Biol Macromol.2021, 199:189-200.
  • Biomedicines.2022, 10(2):463.
  • Food Res Int.2019, 123:125-134
  • J of Health Science and Alternative Medicine2019, 1(1)
  • FASEB J.2022, 36(7):e22387.
  • Int J Mol Sci.2020, 21(24):9369.
  • Horticulturae2022, 8(10), 975.
  • Food Science&Tech. Res.2022, 28(2):123-132.
  • Medicina (Kaunas).2020, 56(12):685.
  • Virulence.2018, 9(1):588-603
  • Korean J Acupunct2020, 37:104-121
  • Separations2021, 8(1), 1.
  • ...
  • 生物活性
    Description: Licraside(licuraside) has potency and ability to inhibit mushroom tyrosinase monophenolase activity with an IC(50) value of 0.072 mM. Licraside(Licurazid) has anticancer properties.
    In vitro:
    J Agric Food Chem. 2005 Sep 21;53(19):7408-7414.
    Isolation and identification of flavonoids in licorice and a study of their inhibitory effects on tyrosinase[Pubmed: 16159166]
    Five different flavonoids were isolated from licorice after multistep chromatographic fractionation. The aim was to identify and characterize active components in licorice responsible for antibrowning activities and to seek new tyrosinase inhibitors for applications as antibrowning and depigmenting agents in the food and cosmetic industries. The isolated flavonoids were identified as liquiritin, licuraside, isoliquiritin, liquiritigenin (from Glycyrrhiza uralensis Fisch.), and licochalcone A (from Glycyrrhiza inflate Bat.) by UV, MS, (1)H NMR, and (13)C NMR analyses. The inhibitory potencies and capacities of these flavonoids toward monophenolase activity of mushroom tyrosinase were investigated. The IC(50) values of licuraside, isoliquiritin, and licochalcone A for monophenolase activity were 0.072, 0.038, and 0.0258 mM, respectively. A study of the mechanisms of monophenolase inhibition by these flavonoids indicated that they are all competitive inhibitors. Different from the above flavonoids, no inhibitory activity was observed for liquiritin, whereas liquiritigenin activated the monophenolase activity as a cofactor. The inhibitory effect of licuraside, isoliquiritin, and licochalcone A on diphenolase activity with l-DOPA as the substrate was much lower than those with l-tyrosine. Results suggest that licuraside, isoliquiritin, and licochalcone A have the high potential to be further developed into effective antibrowning and depigmenting agents.
    Planta Med . 1989 Feb;55(1):22-26.
    The existence of aldose reductase inhibitors in some kampo medicines (Oriental herb prescriptions)[Pubmed: 2497475]
    Traditionally in Japan, some kampo medicines which contain Glycyrrhizae radix (GR) and Paeoniae radix (PR) have long been used for the treatment of diabetic neuropathy. Since we have previously shown that GR und PR have potent aldose reductase inhibitory activities, we further investigated the constituents of these two. The boiled water extract of GR was applied to Sephadex LH-20 column chromatography and 6 fractions (Frs. A, B, Cs, Cp, D, and E) were obtained. Frs. Cp and D were retreated in the same manner and 7 pure compounds (GUs 1-7) were obtained. The boiled water extract of PR was fractionated with ethyl acetate followed by n-butanol and 3 fractions (Frs. 1-3) were collected. Fr. 1 was retreated in the same manner and 2 pure compounds (PRs 1 and 2) were obtained. Among the GU compounds, GU-2 was the most potent inhibitor of rat lens aldose reductase (RLAR) by inhibiting 86% at the concentration of 1.0 microgram/ml. The IC50 of GU-2 was 7.2 x 10(-7) M. Furthermore, GU-2 markedly inhibited sorbitol accumulation in human red blood cells, having an IC50 of 2.9 x 10(-5) M. GU-5 and PR-1 also inhibited RLAR (IC50: 5.6 x 10(-7) M and 6.3 x 10(-7) M, respectively). The structures of GU-2, GU-5, and PR-1 were identified as isoliquiritin, licuraside, and 1, 2, 3, 6-tetra-O-galloyl-beta-D-glucose, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
    Anticancer Res. 2013 Aug;33(8):3061-3068.
    Evaluation of cytotoxiciy and tumor-specificity of licorice flavonoids based on chemical structure[Pubmed: 23898061]
    Background: The mechanism of cytotoxicity induction by flavonoids has been studied by many investigators, but their tumor specificity is not clear. To address this point, 10 licorice flavonoids were subjected to quantitative structure-activity relationship (QASR) analysis with cytotoxicity assay with four human oral carcinoma and three normal cell lines. Materials and methods: Cytotoxicity was determined by the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide method. Physico-chemical, structural, and quantum-chemical parameters were calculated based on the conformations optimized by the LowModeMD method. Results: Licurazid and isoliquiritigenin had the highest cytotoxicity against tumor cells, and liquiritin, isoliquiritin and licurazid had the highest tumor specificity, suggesting an antitumor potential for licurazid. Chalcones had slightly higher cytotoxicity and tumor specificity than flavanones. The number of sugar units in the molecule was somewhat negatively-correlated with cytotoxicity, but not with tumor specificity. Parameters that reflect the three-dimensional structure, molecular volume and number of phenolic OH groups were significantly correlated with cytotoxicity, but not with tumor specificity. On the other hand, solvation energy was significantly correlated with tumor specificity, but not with cytotoxicity. Conclusion: These physicochemical descriptors may be useful to estimate cytotoxicity or tumor specificity of structurally-related compounds to these licorice flavonoids.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8165 mL 9.0825 mL 18.165 mL 36.3299 mL 45.4124 mL
    5 mM 0.3633 mL 1.8165 mL 3.633 mL 7.266 mL 9.0825 mL
    10 mM 0.1816 mL 0.9082 mL 1.8165 mL 3.633 mL 4.5412 mL
    50 mM 0.0363 mL 0.1816 mL 0.3633 mL 0.7266 mL 0.9082 mL
    100 mM 0.0182 mL 0.0908 mL 0.1816 mL 0.3633 mL 0.4541 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    沙帕色替; Sapanisertib (MLN0128) CFN60099 1224844-38-5 C15H15N7O = 309.33 5mg QQ客服:3257982914
    Bryonolol; Bryonolol CFN90562 39765-50-9 C30H50O2 = 442.7 5mg QQ客服:1457312923
    Ammijin; Ammijin CFN92711 495-30-7 C20H24O9 = 408.4 5mg QQ客服:2159513211
    双旋覆花内酯丁; Japonicone D CFN92708 1078711-42-8 C34H44O9 = 596.7 5mg QQ客服:1413575084

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