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  • 6,4'-Dihydroxy-7-methoxyflavanone

    • 6,4'-Dihydroxy-7-methoxyflavanone

    6,4'-Dihydroxy-7-methoxyflavanone

    6,4'-Dihydroxy-7-methoxyflavanone
    		产品编号 CFN89523
    CAS编号 189689-32-5
    分子式 = 分子量 C16H14O5 = 286.27
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The heartwoods of Dalbergia odorifera.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    6,4'-Dihydroxy-7-methoxyflavanone CFN89523 189689-32-5 1mg QQ客服：215959384
    6,4'-Dihydroxy-7-methoxyflavanone CFN89523 189689-32-5 5mg QQ客服：215959384
    6,4'-Dihydroxy-7-methoxyflavanone CFN89523 189689-32-5 10mg QQ客服：215959384
    6,4'-Dihydroxy-7-methoxyflavanone CFN89523 189689-32-5 20mg QQ客服：215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Nat Prod.2017, 80(4):854-863
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  • Molecules.2024, 29(5):1048.
  • JMicrobiol Biotech Food Sci2021, e4289.
  • Mol Plant Pathol.2023, 24(2):123-141.
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  • Phytother Res.2019, 33(7):1784-1793
  • Anal Sci.2019, 35(12):1317-1325
  • Metabolites.2023, 13(6):689.
  • J Microbiol Immunol Infect.2021, S1684-1182(21)00142-0.
  • Auburn University2015, 1-58
  • Phytomedicine.2024, 155760.
  • PLoS One.2021, 16(6):e0248479.
  • J Microbiol Biotechnol.2020, 30(2):178-186.
  • Korean J. Medicinal Crop Sci.2018, 26(2):148-156
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  • ...
    • 生物活性
    Description: 6,4'-Dihydroxy-7-methoxyflavanone has antioxidant, anti-inflammatory and neuroprotective effects. It shows inhibition of osteoclasts differentiation and function, it can be a potential therapeutic molecule for osteoclastogenic bone diseases such osteoporosis, rheumatoid arthritis and periodontal diseases.
    Targets: NF-kB | HO-1 | MAPK | JNK | PGE | TNF-α | IL Receptor | ERK
    In vitro:
    Eur J Pharmacol. 2012 Jan 15;674(2-3):153-62.
    Involvement of heme oxygenase-1 induction in the cytoprotective and immunomodulatory activities of 6,4'-dihydroxy-7-methoxyflavanone in murine hippocampal and microglia cells.[Pubmed: 22119385]
    6,4'-Dihydroxy-7-methoxyflavanone (DMF), a biologically active compound, was isolated from the heartwood of Dalbergia odorifera T. Chen (Leguminosae).
    METHODS AND RESULTS:
    The present study proposed to examine the role of DMF as an anti-oxidative and anti-inflammatory heme oxygenase-1 (HO-1) inducer in mouse hippocampal HT22 cells and BV2 microglia cells. The effect of DMF on cell viability was determined by MTT assay and the effects of DMF on pro-inflammatory enzymes and cytokines were analyzed by western blot and ELISA. Parameters such as DMF induced HO-1 protein immunocontents, HO activity and mitogen-activated protein kinases (MAPK) activation were also measured. DMF increased cellular resistance to oxidative injury caused by glutamate-induced cytotoxicity in HT22 cells, via JUN N-terminal kinase (JNK) pathway dependent HO-1 expression. Furthermore, DMF suppressed the lipopolysaccharide (LPS)-induced expression of pro-inflammatory enzymes and inflammatory mediators in BV2 microglia. DMF suppressed production of nitric oxide (NO), prostaglandin E2 (PGE(2)), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), through extracellular signal-regulated kinase (ERK) pathway dependent HO-1 expression.
    CONCLUSIONS:
    This study indicates that DMF effectively modulates the regulation of anti-oxidative and anti-inflammatory action, via up-regulation of HO-1 in HT22 cells and BV2 microglia. These results suggest that DMF possesses therapeutic potentials against neurodegenerative diseases that are induced by oxidative stress and neuroinflammation.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.4932 mL 17.466 mL 34.9321 mL 69.8641 mL 87.3301 mL
    5 mM 0.6986 mL 3.4932 mL 6.9864 mL 13.9728 mL 17.466 mL
    10 mM 0.3493 mL 1.7466 mL 3.4932 mL 6.9864 mL 8.733 mL
    50 mM 0.0699 mL 0.3493 mL 0.6986 mL 1.3973 mL 1.7466 mL
    100 mM 0.0349 mL 0.1747 mL 0.3493 mL 0.6986 mL 0.8733 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    柚皮素； 4',5,7-三羟基黄烷酮; Naringenin CFN98742 480-41-1 C15H12O5 = 272.3 20mg QQ客服：1457312923
    4',7-二乙酸橘皮素酯; Naringenin-4',7-diacetate CFN99848 18196-13-9 C19H16O7 = 356.3 5mg QQ客服：2159513211
    三乙酸柚皮素酯; Naringenin triacetate CFN98603 3682-04-0 C21H18O8 = 398.4 5mg QQ客服：3257982914
    5-O-甲基柚皮素; 5-O-Methylnaringenin CFN97060 61775-19-7 C16H14O5 = 286.3 5mg QQ客服：215959384
    樱花亭; Sakuranetin CFN98366 2957-21-3 C16H14O5 = 286.3 20mg QQ客服：215959384
    异樱花亭; Isosakuranetin CFN98743 480-43-3 C16H14O5 = 286.3 20mg QQ客服：1413575084
    Tsugafolin; Tsugafolin CFN96126 66568-97-6 C17H16O5 = 300.3 5mg QQ客服：1457312923
    (S)-5-羟基-7,4'-二甲氧基黄烷酮; 4',7-Di-O-methylnaringenin CFN98364 29424-96-2 C17H16O5 = 300.3 20mg QQ客服：1457312923
    柚皮素三甲醚; Naringenin trimethyl ether CFN98616 38302-15-7 C18H18O5 = 314.3 10mg QQ客服：1457312923
    6-甲氧基柚皮素; 6-Methoxynaringenin CFN97529 94942-49-1 C16H14O6 = 302.3 5mg QQ客服：2056216494

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